Lutetium Lu 177 dotatate Brand Name– Lutathera
What is Lutetium Lu 177 dotatate
Lutetium Lu 177 dotatate is a radiolabeled somatostatin analog indicated for the treatment of somatostatin receptor-positive gastroenteropancreatic neuroendocrine tumors (GEP-NETs) in adults.
Premedicate with antiemetics as well as an amino acid solution.
Because lutetium Lu 177 dotatate is a radiopharmaceutical, appropriate safety measures should be undertaken to minimize radiation exposure
Indications
- malignant neuroendocrine tumor (NET)
For the treatment of somatostatin receptor-positive gastroenteropancreatic malignant neuroendocrine tumor (NET), including foregut, midgut, and hindgut neuroendocrine tumors
Side Effects
- abdominal pain
- abdominal pain
- alopecia
- anemia
- anorexia
- anxiety
- anxiety
- atrial fibrillation
- atrial fibrillation
- azotemia
- back pain
- back pain
- bronchospasm
- cholestasis
- colic
- constipation
- cough
- cough
- diarrhea
- diarrhea
- dizziness
- dysgeusia
- dysuria
- elevated hepatic enzymes
- elevated hepatic enzymes
- fatigue
- fatigue
- fever
- flushing
- flushing
- headache
- heart failure
- hyperbilirubinemia
- hyperbilirubinemia
- hyperglycemia
- hyperglycemia
- hyperkalemia
- hypernatremia
- hypertension
- hypertension
- hyperuricemia
- hyperuricemia
- hypocalcemia
- hypoglycemia
- hypokalemia
- hypokalemia
- hypotension
- leukopenia
- leukopenia
- lymphopenia
- lymphopenia
- myalgia
- myocardial infarction
- nausea
- nausea
- neuroendocrine hormonal crisis
- neutropenia
- neutropenia
- new primary malignancy
- nocturia
- pelvic pain
- peripheral edema
- renal failure (unspecified)
- renal failure (unspecified)
- thrombocytopenia
- thrombocytopenia
- urethral pain
- urinary incontinence
- vomiting
- vomiting
Monitoring Parameters
- CBC with differential
- LFTs
- pregnancy testing
- serum albumin
- serum creatinine
Contraindications
- anemia
- bone marrow suppression
- breast-feeding
- contraception requirements
- hepatic disease
- infertility
- neuroendocrine hormonal crisis
- neutropenia
- new primary malignancy
- pregnancy
- pregnancy testing
- radiation exposure
- renal disease
- renal impairment
- reproductive risk
- thrombocytopenia
Interactions
- Lanreotide
- Octreotide
- Palifermin
- Penicillamine
- Tuberculin Purified Protein Derivative, PPD
