Luliconazole

Luliconazole Brand Name– LUZU

What is Luliconazole

Luliconazole is a topical azole antifungal cream indicated for the treatment of interdigital tinea pedis, tinea cruris, and tinea corporis caused by the organisms Trichophyton rubrum or Epidermophyton floccosum.

It is approved in adult and pediatric patients 12 years and older for tinea pedis and tinea cruris and in adult and pediatric patients 2 years and older for tinea corporis.

In tinea pedis studies in adults, complete clearance (defined as clinical cure and mycological cure) at 4 weeks post-treatment was achieved in 26% and 14% of luliconazole recipients compared to 2% and 3% of patients receiving the vehicle cream.

Similar results were observed in the tinea cruris study with 21% of patients receiving the active drug and 4% of patients receiving the vehicle cream achieving complete clearance at 3 weeks post-treatment.

In the tinea corporis study in pediatric patients 2 years and older, complete clearance (defined as clinical cure and mycological cure) at 3 weeks post-treatment was achieved in 71% of luliconazole recipients compared to 36% of patients receiving the vehicle cream.

Indications

  1. Epidermophyton floccosum
  2. tinea corporis
  3. tinea cruris
  4. tinea pedis
  5. Trichophyton rubrum

Side Effects

  • contact dermatitis
  • skin irritation

Application site reactions (i.e., skin irritation) were observed in < 1% of patients treated with luliconazole during clinical trials. An evaluation of these reactions showed most were mild in severity. Cases of contact dermatitis and cellulitis have been noted with post-marketing use

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • azole antifungals hypersensitivity
  • breast-feeding
  • ocular exposure
  • ophthalmic administration
  • pregnancy

Interactions

  • Acetaminophen; Diphenhydramine
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Omeprazole
  • Atovaquone; Proguanil
  • Bortezomib
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carisoprodol
  • Cilostazol
  • Citalopram
  • Clomipramine
  • Clopidogrel
  • Cyclophosphamide
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Diazepam
  • Diphenhydramine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Diphenhydramine; Phenylephrine
  • Doxepin
  • Escitalopram
  • Esomeprazole
  • Esomeprazole; Naproxen
  • Etravirine
  • Imipramine
  • Lacosamide
  • Lansoprazole
  • Lansoprazole; Naproxen
  • Methadone
  • Omeprazole
  • Omeprazole; Amoxicillin; Rifabutin
  • Omeprazole; Sodium Bicarbonate
  • Oxybutynin
  • Propafenone
  • Quinine
  • Rabeprazole
  • Terbinafine
  • Voriconazole
  • Warfarin
  • Ziprasidone
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