Lucinactant

Lucinactant Brand Name– SURFAXIN

What is Lucinactant

Lucinactant is a synthetic surfactant replacement therapy indicated for the prevention of respiratory distress syndrome (RDS) in premature neonates.

Lucinactant contains the proprietary peptide ‘sinapultide’, which was designed to mimic the human surfactant protein B (SP-B).

The product contains 4 active pharmaceutical ingredients: a novel peptide, a fatty acid, and 2 phospholipids.

Results from a clinical trial in premature infants with RDS (n = 1036) indicated that infants treated with lucinactant demonstrated a statistically significant improvement in RDS at 24 hours (39% vs 47%; p < 0.01) and RDS-related mortality through day 14 (5% vs 9%; p < 0.01) as compared with those infants treated with another synthetic surfactant, colfosceril.

Lucinactant was investigated for the treatment of acute respiratory distress syndrome (ARDS) in adults; however, due to an increased incidence of serious adverse events (death, multi-organ failure, sepsis, anoxic encephalopathy, renal failure, hypoxia/decreased oxygen saturation, pneumothorax, hypotension, and pulmonary embolism), it is not indicated for the treatment of ARDS in adults.

Lucinactant was approved by the FDA in March 2012 for the prevention of RDS in premature neonates

Indications

  • neonatal respiratory distress syndrome prophylaxis

For neonatal respiratory distress syndrome prophylaxis in premature neonates

Side Effects

  1. anemia
  2. bradycardia
  3. hyperglycemia
  4. hyponatremia
  5. hypotension
  6. jaundice
  7. metabolic acidosis

Monitoring Parameters

  • arterial blood gases (ABGs)
  • chest x-ray

Contraindications

  • bradycardia
  • breast-feeding
  • pregnancy
  • requires an experienced clinician
  • respiratory distress syndrome

Interactions

No information is available regarding drug interactions associated with Lucinactant –