Isatuximab

Isatuximab Brand Name– SARCLISA

What is Isatuximab

Isatuximab is a CD-38 directed cytolytic antibody indicated in combination with pomalidomide and dexamethasone for the treatment of adult patients with multiple myeloma who have received at least 2 prior therapies including lenalidomide and a proteasome inhibitor.

Because isatuximab binds to CD38 on red blood cells, it may interfere with the ability to determine a patient’s blood type and result in a false positive indirect antiglobulin test (Coombs test).

Additionally, isatuximab may interfere with the determination of complete response in some patients. Patients should have their blood typed and screened prior to starting treatment

Indications

  • multiple myeloma

For the treatment of multiple myeloma

NOTE: The FDA has designated isatuximab as an orphan drug for the treatment of multiple myeloma.

for the treatment of multiple myeloma in patients who have received at least 2 prior therapies including lenalidomide and a proteasome inhibitor, in combination with pomalidomide and dexamethasone

Side Effects

  1. anemia
  2. anemia
  3. antibody formation
  4. bronchospasm
  5. chills
  6. cough
  7. diarrhea
  8. diarrhea
  9. dyspnea
  10. dyspnea
  11. hypertension
  12. infection
  13. infection
  14. influenza
  15. infusion-related reactions
  16. infusion-related reactions
  17. laryngitis
  18. lymphopenia
  19. lymphopenia
  20. nausea
  21. neutropenia
  22. neutropenia
  23. new primary malignancy
  24. pharyngitis
  25. sinusitis
  26. skin cancer
  27. thrombocytopenia
  28. thrombocytopenia
  29. tracheitis
  30. vomiting
  31. vomiting

Monitoring Parameters

  • CBC with differential
  • pregnancy testing
  • Rh serology
  • skin cancer screening exam

Contraindications

  • breast-feeding
  • contraception requirements
  • infusion-related reactions
  • laboratory test interference
  • neutropenia
  • new primary malignancy
  • pregnancy
  • pregnancy testing
  • reproductive risk
  • vaccination

Interactions

There are no drug interactions associated with Isatuximab products.

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