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Lomustine CCNU Brand Names- CeeNU | Gleostine
What is Lomustine CCNU
Lomustine is a nitrosourea alkylating agent that is indicated for the treatment of Hodgkin lymphoma and brain cancers.
Fatal myelosuppression has been reported.
Prescribe, dispense, and administer only 1 lomustine dose at a time to minimize the risk of an overdose; lomustine is administered at a minimum of 6-week intervals
Indications
- acute myelogenous leukemia (AML)
- brain metastases
- Hodgkin lymphoma
- malignant glioma
- malignant melanoma
- non-Hodgkin’s lymphoma (NHL)
For the treatment of Hodgkin lymphoma in patients who have progressive disease following initial chemotherapy, in combination with other chemotherapeutic agents
Side Effects
- alopecia
- ataxia
- bleeding
- bone marrow suppression
- dysarthria
- elevated hepatic enzymes
- hyperbilirubinemia
- infection
- lethargy
- leukopenia
- nausea
- new primary malignancy
- optic atrophy
- pulmonary fibrosis
- pulmonary toxicity
- renal failure (unspecified)
- stomatitis
- thrombocytopenia
- visual impairment
- vomiting
Monitoring Parameters
- CBC
- LFTs
- pulmonary function tests (PFTs)
- serum creatinine/BUN
- serum electrolytes
Contraindications
- bleeding
- bone marrow suppression
- breast-feeding
- chemotherapy
- contraception requirements
- hepatotoxicity
- infection
- infertility
- leukopenia
- male-mediated teratogenicity
- nephrotoxicity
- new primary malignancy
- potential for overdose or poisoning
- pregnancy
- pulmonary disease
- pulmonary fibrosis
- renal failure
- reproductive risk
- thrombocytopenia
- vaccination
Interactions
- Abciximab
- Alpha interferons
- Alteplase
- Amlodipine; Celecoxib
- Anagrelide
- Anticoagulants
- Antithrombin III
- Apixaban
- Argatroban
- Aspirin, ASA; Dipyridamole
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Azelastine; Fluticasone
- Bacillus Calmette-Guerin Vaccine, BCG
- Beclomethasone
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Betamethasone
- Betrixaban
- Bivalirudin
- Budesonide
- Budesonide; Formoterol
- Celecoxib
- Ciclesonide
- Cilostazol
- Cimetidine
- Clopidogrel
- Clozapine
- Corticosteroids
- Cortisone
- Dabigatran
- Dalteparin
- Danaparoid
- Deflazacort
- Desirudin
- Dexamethasone
- Diclofenac
- Diclofenac; Misoprostol
- Diflunisal
- Digoxin
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Dipyridamole
- Echinacea
- Edoxaban
- Enoxaparin
- Eptifibatide
- Esomeprazole; Naproxen
- Etodolac
- Famotidine; Ibuprofen
- Febuxostat
- Fenoprofen
- Filgrastim, G-CSF
- Fludrocortisone
- Flunisolide
- Flurbiprofen
- Fluticasone
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Fondaparinux
- Formoterol; Mometasone
- Heparin
- Hydrocodone; Ibuprofen
- Hydrocortisone
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Indomethacin
- Influenza Virus Vaccine
- Interferon Alfa-2a
- Interferon Alfa-2b
- Interferon Alfa-2b; Ribavirin
- Interferon Alfa-n3
- Interferon Alfacon-1
- Intranasal Influenza Vaccine
- Ketoprofen
- Ketorolac
- Lansoprazole; Naproxen
- Lepirudin
- Live Vaccines
- Measles Virus; Mumps Virus; Rubella Virus; Varicella Virus Vaccine, Live
- Measles/Mumps/Rubella Vaccines, MMR
- Meclofenamate Sodium
- Mefenamic Acid
- Meloxicam
- Methylprednisolone
- Mometasone
- Nabumetone
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Nonsteroidal antiinflammatory drugs
- Oxaprozin
- Palifermin
- Pegfilgrastim
- Peginterferon Alfa-2a
- Peginterferon Alfa-2b
- Penicillamine
- Pentosan
- Phenobarbital
- Piroxicam
- Platelet Inhibitors
- Prasugrel
- Prednisolone
- Prednisone
- Procarbazine
- Reteplase, r-PA
- Rivaroxaban
- Rofecoxib
- Rotavirus Vaccine
- Rubella Virus Vaccine Live
- Smallpox and Monkeypox Vaccine, Live, Nonreplicating
- Smallpox Vaccine, Vaccinia Vaccine
- Streptokinase
- Sulindac
- Tbo-Filgrastim
- Tenecteplase
- Thrombolytic Agents
- Ticagrelor
- Ticlopidine
- Tinzaparin
- Tirofiban
- Tolmetin
- Triamcinolone
- Tuberculin Purified Protein Derivative, PPD
- Typhoid Vaccine
- Urokinase
- Valdecoxib
- Varicella-Zoster Virus Vaccine, Live
- Vorapaxar
- Warfarin
- Yellow Fever Vaccine, Live
