Lincomycin Brand Name– Lincocin
What is Lincomycin
Lincomycin is a lincosamide antibiotic, structurally related to clindamycin.
Lincomycin was isolated in 1962 from a soil organism, Streptomyces lincolnensis.
Further chemical alteration resulted in the production of clindamycin, an antibiotic with greater antimicrobial activity; there is no advantage to using lincomycin over clindamycin, and lincomycin is rarely used clinically today.
Lincomycin is indicated for the treatment of serious staphylococcal, pneumococcal, and streptococcal infections in penicillin-allergic patients when treatment with less toxic agents (e.g., erythromycin) is not appropriate.
Lincomycin should be avoided in patients with an allergy to clindamycin. Complete bacterial cross resistance has been seen with clindamycin; however, partial cross resistance may also be encountered with lincomycin and agents in the macrolide class.
Susceptibility testing is recommended. As with other antibiotics, lincomycin has been associated with severe or fatal pseudomembranous colitis.
Lincomycin was FDA-approved in 1964.
Indications
- bacteremia
- Clostridium perfringens
- Clostridium tetani
- Corynebacterium diphtheriae
- ocular surgery
- Staphylococcus aureus (MRSA)
- Staphylococcus aureus (MSSA)
- Streptococcus pneumoniae
- Streptococcus pyogenes (group A beta-hemolytic streptococci)
- Viridans streptococci
Side Effects
- abdominal pain
- acute generalized exanthematous pustulosis (AGEP)
- agranulocytosis
- anaphylactic shock
- anaphylactoid reactions
- angioedema
- aplastic anemia
- azotemia
- bullous rash
- candidiasis
- cardiac arrest
- diarrhea
- dizziness
- drowsiness
- elevated hepatic enzymes
- erythema multiforme
- exfoliative dermatitis
- glossitis
- headache
- hypotension
- injection site reaction
- jaundice
- leukopenia
- nausea
- neutropenia
- oliguria
- pancytopenia
- phlebitis
- proteinuria
- pruritus
- pruritus ani
- pseudomembranous colitis
- rash
- serum sickness
- Stevens-Johnson syndrome
- stomatitis
- superinfection
- thrombotic thrombocytopenic purpura (TTP)
- tinnitus
- toxic epidermal necrolysis
- urticaria
- vaginitis
- vertigo
- vomiting
Monitoring Parameters
- CBC
- LFTs
- serum creatinine/BUN
Contraindications
- asthma
- atopy
- benzyl alcohol hypersensitivity
- breast-feeding
- clindamycin hypersensitivity
- colitis
- diarrhea
- fungal infection
- hepatic disease
- infants
- inflammatory bowel disease
- lincomycin hypersensitivity
- neonates
- pregnancy
- pseudomembranous colitis
- renal disease
- renal failure
- renal impairment
- ulcerative colitis
- viral infection
Interactions
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Codeine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Propoxyphene
- Alfentanil
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Oxycodone
- Atracurium
- Belladonna; Opium
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Cisatracurium
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Cyclosporine
- Dienogest; Estradiol valerate
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Doxacurium
- Enflurane
- Estradiol
- Estradiol Cypionate; Medroxyprogesterone
- Fentanyl
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Halothane
- Homatropine; Hydrocodone
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydromorphone
- Ibuprofen; Oxycodone
- Isoflurane
- Levorphanol
- Meperidine
- Meperidine; Promethazine
- Methadone
- Mivacurium
- Morphine
- Morphine; Naltrexone
- Neuromuscular blockers
- Opiate Agonists
- Oral Contraceptives
- Oxycodone
- Oxymorphone
- Pancuronium
- Propoxyphene
- Rapacuronium
- Remifentanil
- Rocuronium
- Sevoflurane
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- Succinylcholine
- Sufentanil
- Tubocurarine
- Vecuronium
- Vitamin C
- Warfarin
