Levothyroxine Liothyronine Porcine

Levothyroxine Liothyronine Porcine Brand Names

Armour Thyroid | Bio-Throid | Nature Thyroid | Nature-Throid | NP Thyroid | Westhroid | WP Thyroid

What is Levothyroxine Liothyronine Porcine

Levothyroxine Liothyronine (Porcine) also known as desiccated thyroid, is a naturally occurring thyroid hormone derived from porcine thyroid glands. The tablets provide 38 mcg levothyroxine (T4) and 9 mcg liothyronine (T3) per grain (60 mg) of thyroid.

Thyroid hormone is used to treat hypothyroidism that results from primary atrophy of the gland, functional thyroid deficiency, or decreased thyroid function secondary to surgery, radiation, or antithyroid agents.

The preparation is also used to treat pituitary hypothyroidism, hypothalamic hypothyroidism, and cretinism.

Dessicated thyroid may also be used rarely as a pituitary TSH suppressant, in the treatment or prevention of various types of euthyroid goiters, including thyroid nodules, subacute or chronic Iymphocytic thyroiditis (Hashimoto’s), multinodular goiter, and in the management of certain types of thyroid cancer.

Until the 1970’s, thyroid hormone replacement therapy was performed with desiccated thyroid extracts.

Because of considerable variations in levothyroxine (T4) and liothyronine (T3) content, these dessicated thyroid hormone extracts have been largely replaced in clinical medicine by the preferred use of synthetic levothyroxine (T4), which has a more reliable hormonal content, providing consistent gastrointestinal absorption, once-daily dosing, and provision of clinically stable serum levels of both T4 and T3.

There is scientific and clinical evidence that the majority of the biologically active T3 hormone is generated from T4 in the human body.

The replacement of thyroid hormone using synthetic levothyroxine (T4) is alone sufficient in most individuals with hypothyroidism, and is the preferred replacement therapy for routine use.

Levothyroxine Liothyronine (Porcine) has been in clinical use since 1939.

Indications

  • goiter
  • hypothyroidism

Thyroid Products Equivalent Oral Dosages (listings are estimates only):

Preparation Equivalent dosage (T4: T3 ratio)

  • Levothyroxine 0.1 mg (1:0)
  • Liothyronine 25 mcg (0:1)
  • Liotrix-1 50—60mcg/12.5—15mcg (4:1)
  • Thyroid USP 60 mg (1 grain) (2—5:1)

For the treatment of hypothyroidism of any etiology, and for the treatment or prevention of various types of euthyroid (non-toxic) goiter

Side Effects

  1. alopecia
  2. amenorrhea
  3. angina
  4. anorexia
  5. anxiety
  6. appetite stimulation
  7. atrial fibrillation
  8. cardiac arrest
  9. craniosynostosis
  10. diaphoresis
  11. diarrhea
  12. dyspnea
  13. elevated hepatic enzymes
  14. emotional lability
  15. fatigue
  16. fever
  17. flushing
  18. growth inhibition
  19. headache
  20. heart failure
  21. heat intolerance
  22. hypertension
  23. hyperthyroidism
  24. infertility
  25. insomnia
  26. irritability
  27. menstrual irregularity
  28. muscle cramps
  29. myocardial infarction
  30. nausea
  31. osteopenia
  32. osteoporosis
  33. palpitations
  34. peripheral edema
  35. pseudotumor cerebri
  36. sinus tachycardia
  37. thyrotoxicosis
  38. tremor
  39. vomiting
  40. weakness
  41. weight loss

Monitoring Parameters

  • blood pressure
  • heart rate
  • thyroid function tests (TFTs)
  • total T3 (triiodothyronine)

Contraindications

  • acute myocardial infarction
  • adrenal insufficiency
  • angina
  • breast-feeding
  • cardiac arrhythmias
  • cardiac disease
  • coronary artery disease
  • diabetes mellitus
  • geriatric
  • hypertension
  • hypopituitarism
  • infertility
  • neonates
  • obesity treatment
  • osteoporosis
  • porcine protein hypersensitivity
  • pregnancy
  • surgery
  • thyrotoxicosis

Interactions

  • Acarbose
  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetohexamide
  • Albiglutide
  • Alendronate
  • Alendronate; Cholecalciferol
  • Alogliptin
  • Alogliptin; Metformin
  • Alogliptin; Pioglitazone
  • Alpha-glucosidase Inhibitors
  • Aluminum Hydroxide
  • Aluminum Hydroxide; Magnesium Carbonate
  • Aluminum Hydroxide; Magnesium Hydroxide
  • Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
  • Aluminum Hydroxide; Magnesium Trisilicate
  • Amiodarone
  • Amobarbital
  • Amoxapine
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Asparaginase Erwinia chrysanthemi
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Omeprazole
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Azelastine; Fluticasone
  • Barbiturates
  • Beclomethasone
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Beta-agonists
  • Beta-blockers
  • Betamethasone
  • Budesonide
  • Budesonide; Formoterol
  • Butabarbital
  • Calcium
  • Calcium Acetate
  • Calcium Carbonate
  • Calcium Carbonate; Magnesium Hydroxide
  • Calcium Carbonate; Risedronate
  • Calcium Carbonate; Simethicone
  • Calcium Chloride
  • Calcium Gluconate
  • Calcium; Vitamin D
  • Canagliflozin
  • Canagliflozin; Metformin
  • Carbamazepine
  • Chlorpropamide
  • Cholestyramine
  • Chromium
  • Ciclesonide
  • Cocaine
  • Colesevelam
  • Colestipol
  • Corticosteroids
  • Cortisone
  • Cyclosporine
  • Dapagliflozin
  • Dapagliflozin; Metformin
  • Dapagliflozin; Saxagliptin
  • Deflazacort
  • Dexamethasone
  • Dexlansoprazole
  • Didanosine, ddI
  • Digoxin
  • Dulaglutide
  • Empagliflozin
  • Empagliflozin; Linagliptin
  • Empagliflozin; Linagliptin; Metformin
  • Empagliflozin; Metformin
  • enteral feedings
  • Ertugliflozin; Metformin
  • Ertugliflozin; Sitagliptin
  • Esomeprazole
  • Esomeprazole; Naproxen
  • Estrogens
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Exenatide
  • Fludrocortisone
  • Flunisolide
  • Fluoxymesterone
  • Fluticasone
  • Fluticasone; Salmeterol
  • Fluticasone; Umeclidinium; Vilanterol
  • Fluticasone; Vilanterol
  • food
  • Formoterol; Mometasone
  • Furosemide
  • Glimepiride
  • Glimepiride; Pioglitazone
  • Glimepiride; Rosiglitazone
  • Glipizide
  • Glipizide; Metformin
  • Glyburide
  • Glyburide; Metformin
  • Hetastarch; Dextrose; Electrolytes
  • Hydantoins
  • Hydrocortisone
  • Imatinib
  • Indinavir
  • Insulin Degludec; Liraglutide
  • Insulin Glargine; Lixisenatide
  • Insulins
  • Iodine; Potassium Iodide, KI
  • Iodoquinol
  • Iohexol
  • Iopamidol
  • Iopromide
  • Ioversol
  • Iron
  • Iron Salts
  • Iron Sucrose, Sucroferric Oxyhydroxide
  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
  • Isoniazid, INH; Rifampin
  • Isosulfan Blue
  • Ketamine
  • L-Asparaginase Escherichia coli
  • Lansoprazole
  • Lansoprazole; Naproxen
  • Lanthanum Carbonate
  • Linagliptin
  • Linagliptin; Metformin
  • Liraglutide
  • Lithium
  • Lixisenatide
  • Magnesium
  • Maprotiline
  • Meglitinides
  • Mephobarbital
  • Metformin
  • Metformin; Pioglitazone
  • Metformin; Repaglinide
  • Metformin; Rosiglitazone
  • Metformin; Saxagliptin
  • Metformin; Sitagliptin
  • Methimazole
  • Methohexital
  • Methylprednisolone
  • Miglitol
  • Mometasone
  • Non-Ionic Contrast Media
  • Omeprazole
  • Omeprazole; Amoxicillin; Rifabutin
  • Omeprazole; Sodium Bicarbonate
  • Orlistat
  • Pantoprazole
  • Pentobarbital
  • Phenobarbital
  • Pioglitazone
  • Polycarbophil
  • Polysaccharide-Iron Complex
  • Potassium Iodide, KI
  • Pramlintide
  • Prednisolone
  • Prednisone
  • Primidone
  • Propylthiouracil, PTU
  • Proton pump inhibitors
  • Rabeprazole
  • Raloxifene
  • Rifampin
  • Rosiglitazone
  • Saxagliptin
  • Secobarbital
  • Semaglutide
  • Sevelamer
  • Simethicone
  • Simvastatin; Sitagliptin
  • Sitagliptin
  • Sodium Ferric Gluconate Complex; ferric pyrophosphate citrate
  • Sodium Iodide
  • Sodium Polystyrene Sulfonate
  • Somatropin, rh-GH
  • Sucralfate
  • Sulfonylureas
  • Sympathomimetics
  • Teduglutide
  • Theophylline, Aminophylline
  • Thiazolidinediones
  • Thiopental
  • Tirofiban
  • Tolazamide
  • Tolbutamide
  • Tretinoin, ATRA
  • Triamcinolone
  • Tricyclic antidepressants
  • Warfarin