Letermovir Brand Name– Prevymis
What is Letermovir
Letermovir is a cytomegalovirus (CMV) DNA terminase complex inhibitor indicated for prophylaxis of CMV infection and disease in adult CMV-seropositive recipients of an allogenic hematopoietic stem cell transplant (HSCT).
Prophylaxis may be administered orally or intravenously as the same dose. Dosage adjustments are required when administered with cyclosporine. Significant drug interactions may occur when administered concomitantly with letermovir.
Letermovir can be used in patients with resistance to CMV DNA polymerase inhibitors.
Letermovir was FDA-approved in November 2017.
Indications
- cytomegalovirus (CMV)
- cytomegalovirus (CMV) disease prophylaxis
Per the manufacturer, this drug has been shown to be active against most strains of the following microorganisms either in vitro and/or in clinical infections: cytomegalovirus (CMV)
NOTE: The safety and effectiveness in treating clinical infections due to organisms with in vitro data only have not been established in adequate and well-controlled clinical trials.
For cytomegalovirus (CMV) disease prophylaxis in CMV-seropositive recipients [R+] of an allogeneic hematopoietic stem cell transplant (HSCT)
for cytomegalovirus (CMV) disease prophylaxis in patients without concurrent cyclosporine
Side Effects
- abdominal pain
- atrial fibrillation
- cough
- diarrhea
- dyspnea
- fatigue
- headache
- nausea
- neutropenia
- peripheral edema
- sinus tachycardia
- thrombocytopenia
- vomiting
Monitoring Parameters
- cyclosporine concentrations
- serum creatinine/BUN
Contraindications
- breast-feeding
- hepatic disease
- infertility
- pregnancy
- renal disease
- renal failure
- renal impairment
Interactions
- Abacavir; Dolutegravir; Lamivudine
- Abemaciclib
- Acalabrutinib
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Codeine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Tramadol
- Ado-Trastuzumab emtansine
- Alfentanil
- Alfuzosin
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Almotriptan
- Alogliptin; Pioglitazone
- Alosetron
- Alprazolam
- Amiodarone
- Amitriptyline; Chlordiazepoxide
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Apalutamide
- Aprepitant, Fosaprepitant
- Aripiprazole
- Artemether; Lumefantrine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Atazanavir
- Atazanavir; Cobicistat
- Atorvastatin
- Atorvastatin; Ezetimibe
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Avanafil
- Avapritinib
- Axitinib
- Azelastine; Fluticasone
- Bedaquiline
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Benzhydrocodone; Acetaminophen
- Bortezomib
- Bosentan
- Bosutinib
- Brentuximab vedotin
- Brexpiprazole
- Brigatinib
- Bromocriptine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Budesonide
- Budesonide; Formoterol
- Bupivacaine; Lidocaine
- Buprenorphine
- Buprenorphine; Naloxone
- Buspirone
- Cabazitaxel
- Cabozantinib
- Caffeine; Ergotamine
- Cannabidiol
- Carbamazepine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Cariprazine
- Carvedilol
- Ceritinib
- Cevimeline
- Chlordiazepoxide
- Chlordiazepoxide; Clidinium
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Cilostazol
- Cinacalcet
- Cisapride
- Citalopram
- Clarithromycin
- Clindamycin
- Clobazam
- Clonazepam
- Clorazepate
- Clozapine
- Cobicistat
- Cobimetinib
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Colchicine
- Colchicine; Probenecid
- Conivaptan
- Conjugated Estrogens; Medroxyprogesterone
- Copanlisib
- Crizotinib
- Cyclosporine
- Dabrafenib
- Daclatasvir
- Dapagliflozin; Saxagliptin
- Dapsone
- Darifenacin
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Dasatinib
- Deflazacort
- Delavirdine
- Dexamethasone
- Dexlansoprazole
- Dextromethorphan; Quinidine
- Diazepam
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Dihydroergotamine
- Diltiazem
- Diphenhydramine; Hydrocodone; Phenylephrine
- Disopyramide
- Docetaxel
- Dofetilide
- Dolutegravir
- Dolutegravir; Lamivudine
- Dolutegravir; Rilpivirine
- Donepezil
- Donepezil; Memantine
- Doxorubicin
- Dronabinol
- Dronedarone
- Dutasteride
- Dutasteride; Tamsulosin
- Duvelisib
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elagolix
- Elagolix; Estradiol; Norethindrone acetate
- Elbasvir; Grazoprevir
- Eletriptan
- Elexacaftor; tezacaftor; ivacaftor
- Eliglustat
- Eltrombopag
- Eluxadoline
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Enalapril; Felodipine
- Encorafenib
- Entrectinib
- Eplerenone
- Ergoloid Mesylates
- Ergonovine
- Ergot alkaloids
- Ergotamine
- Erlotinib
- Erythromycin
- Erythromycin; Sulfisoxazole
- Estazolam
- Estradiol Cypionate; Medroxyprogesterone
- Eszopiclone
- Ethosuximide
- Etravirine
- Everolimus
- Ezetimibe; Simvastatin
- Felodipine
- Fentanyl
- Flibanserin
- Flurazepam
- Fluticasone
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Fluvastatin
- Fosamprenavir
- Fosphenytoin
- Fostemsavir
- Gefitinib
- Gemfibrozil
- Gilteritinib
- Glasdegib
- Glecaprevir; Pibrentasvir
- Glimepiride; Pioglitazone
- Glimepiride; Rosiglitazone
- Glyburide
- Glyburide; Metformin
- Granisetron
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guanfacine
- Haloperidol
- Homatropine; Hydrocodone
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydroxyprogesterone
- Ibrutinib
- Ibuprofen; Oxycodone
- Idelalisib
- Ifosfamide
- Iloperidone
- Imatinib
- Indinavir
- Irinotecan
- Irinotecan Liposomal
- Isavuconazonium
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Isradipine
- Ivabradine
- Ivacaftor
- Ivosidenib
- Ixabepilone
- Ketoconazole
- Lacosamide
- Lansoprazole
- Lansoprazole; Naproxen
- Larotrectinib
- Lefamulin
- Lemborexant
- Levomilnacipran
- Lidocaine
- Lidocaine; Prilocaine
- Lomitapide
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Lorlatinib
- Lovastatin
- Lovastatin; Niacin
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Lumateperone
- Lurasidone
- Lurbinectedin
- Macitentan
- Maraviroc
- Medroxyprogesterone
- Mefloquine
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Methadone
- Methylergonovine
- Methylprednisolone
- Methysergide
- Midazolam
- Midostaurin
- Mifepristone
- Mirtazapine
- Modafinil
- Nafcillin
- Naldemedine
- Naloxegol
- Nanoparticle Albumin-Bound Paclitaxel
- Nelfinavir
- Neratinib
- Netupitant, Fosnetupitant; Palonosetron
- Nevirapine
- Niacin; Simvastatin
- Nifedipine
- Nilotinib
- Nimodipine
- Nisoldipine
- Olaparib
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole
- Omeprazole; Amoxicillin; Rifabutin
- Omeprazole; Sodium Bicarbonate
- Ospemifene
- Oxybutynin
- Oxycodone
- Paclitaxel
- Palbociclib
- Panobinostat
- Pantoprazole
- Paricalcitol
- Pazopanib
- Pemigatinib
- Pergolide
- Perindopril; Amlodipine
- Pexidartinib
- Phenobarbital
- Phenytoin
- Pimavanserin
- Pimozide
- Pioglitazone
- Pitavastatin
- Ponatinib
- Pravastatin
- Prednisolone
- Prednisone
- Primidone
- Propafenone
- Quetiapine
- Quinidine
- Quinine
- Ramelteon
- Ranolazine
- Regorafenib
- Repaglinide
- Revefenacin
- Ribociclib
- Ribociclib; Letrozole
- Rifabutin
- Rifampin
- Rilpivirine
- Rimegepant
- Ritonavir
- Roflumilast
- Romidepsin
- Rosiglitazone
- Rosuvastatin
- Ruxolitinib
- Saquinavir
- Saxagliptin
- Segesterone Acetate; Ethinyl Estradiol
- Selexipag
- Selpercatinib
- Selumetinib
- Sibutramine
- Sildenafil
- Silodosin
- Simeprevir
- Simvastatin
- Simvastatin; Sitagliptin
- Siponimod
- Sirolimus
- Sofosbuvir; Velpatasvir
- Sofosbuvir; Velpatasvir; Voxilaprevir
- Solifenacin
- Sonidegib
- St. John’s Wort, Hypericum perforatum
- Sufentanil
- Sunitinib
- Suvorexant
- Tacrolimus
- Tadalafil
- Tamsulosin
- Tasimelteon
- Tazemetostat
- Telithromycin
- Temsirolimus
- Teriflunomide
- Tezacaftor; Ivacaftor
- Theophylline, Aminophylline
- Thioridazine
- Thiotepa
- Ticagrelor
- Tinidazole
- Tipranavir
- Tofacitinib
- Tolterodine
- Tolvaptan
- Toremifene
- Trabectedin
- Tramadol
- Trandolapril; Verapamil
- Trazodone
- Triazolam
- Ubrogepant
- Ulipristal
- Umeclidinium; Vilanterol
- Valbenazine
- Vardenafil
- Vemurafenib
- Venetoclax
- Venlafaxine
- Verapamil
- Vilazodone
- Vinblastine
- Vincristine
- Vincristine Liposomal
- Vinorelbine
- Vorapaxar
- Voriconazole
- Warfarin
- Zanubrutinib
- Ziprasidone
- Zolpidem
