Indacaterol Brand Name– ARCAPTA NEOHALER
What is Indacaterol
Indacaterol is an inhaled long-acting beta-2 agonist (LABA) given once-daily. Indacaterol is indicated for the maintenance treatment of airflow obstruction due to chronic obstructive pulmonary disease (COPD) in adults.
Indacaterol significantly improves exacerbation rates, breathlessness, and health status in patients with COPD.
Due to the onset of effect, LABAs should not be used for relief of acute bronchospasm. According to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines for COPD,
LABAs may be used as initial monotherapy in patients in Groups A and B. In Group C patients, long-acting muscarinic antagonists (LAMAs) are preferred as initial therapy over LABAs due to effectiveness in preventing exacerbations.
In Group D patients, LABAs are used as initial therapy in combination with inhaled corticosteroids (ICS) or LAMAs. At follow-up, if the patient is still experiencing dyspnea, consider switching inhaler device and investigate for other causes of dyspnea.
If the patient has exacerbations, consider triple therapy with a LAMA, a LABA, and ICS.
Indacaterol is not approved for the treatment of asthma and should not be used to treat acute bronchospasm. Indacaterol inhalation was first FDA-approved in 2011.
Indications
- chronic bronchitis
- chronic obstructive pulmonary disease (COPD)
- emphysema
NOTE: Long-acting beta-agonists, such as indacaterol, increase the risk of asthma-related death and are contraindicated as monotherapy in the treatment of asthma. Indacaterol is not indicated for the treatment of asthma; safety and efficacy of this medication in patients with asthma have not been established.
For the maintenance treatment of chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema
Side Effects
- asthma-related death
- bronchospasm
- cough
- diabetes mellitus
- dyspnea
- headache
- heart failure
- hyperglycemia
- hypertension
- hypokalemia
- infection
- muscle cramps
- musculoskeletal pain
- nausea
- pharyngitis
- QT prolongation
- sinus tachycardia
- sinusitis
- ST-T wave changes
- supraventricular tachycardia (SVT)
- tremor
- ventricular tachycardia
- wheezing
- xerostomia
Monitoring Parameters
- pulmonary function tests (PFTs)
Contraindications
- acute bronchospasm
- alcoholism
- asthma
- asthma-related death
- bradycardia
- breast-feeding
- cardiac arrhythmias
- cardiac disease
- children
- coronary artery disease
- diabetes mellitus
- diabetic ketoacidosis
- females
- geriatric
- heart failure
- hepatic disease
- hypertension
- hyperthyroidism
- hypocalcemia
- hypokalemia
- hypomagnesemia
- infants
- labor
- long QT syndrome
- malnutrition
- MAOI therapy
- milk protein hypersensitivity
- monotherapy treatment of asthma
- myocardial infarction
- paradoxical bronchospasm
- pheochromocytoma
- pregnancy
- QT prolongation
- seizure disorder
- seizures
- tachycardia
- thyroid disease
- thyrotoxicosis
Interactions
- Abarelix
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- Acetaminophen; Dextromethorphan; Pseudoephedrine
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