Icatibant

Icatibant Brand Name– FIRAZYR

What is Icatibant

Icatibant (Firazyr) is a selective bradykinin B2 receptor antagonist used subcutaneously to treat acute attacks of hereditary angioedema (HAE) in adults.

HAE is a rare, genetic syndrome that causes subcutaneous and submucosal edema that can affect the upper airways, face, extremities, genitals, and gastrointestinal tract.

If an HAE attack involves the larynx or oropharynx, the attack can be life-threatening. Icatibant is administered upon recognition of an HAE attack.

If symptoms persist or relapse after at least 6 hours following the initial icatibant dose, additional doses may be administered (up to 3 doses in 24 hours).

Unlike ecallantide, icatibant may be administered by the patient after appropriate training by a healthcare professional.

The FDA approved icatibant in August 2011.

Indications

  • ACE-inhibitor induced angioedema
  • hereditary angioedema

For the treatment of acute attacks of hereditary angioedema (HAE)

Side Effects

  1. antibody formation
  2. dizziness
  3. ecchymosis
  4. edema
  5. elevated hepatic enzymes
  6. erythema
  7. fever
  8. headache
  9. hematoma
  10. injection site reaction
  11. nausea
  12. pruritus
  13. rash
  14. urticaria

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • breast-feeding
  • driving or operating machinery
  • labor
  • obstetric delivery
  • pregnancy

Interactions

  • Amlodipine; Benazepril
  • Angiotensin-converting enzyme inhibitors
  • Benazepril
  • Benazepril; Hydrochlorothiazide, HCTZ
  • Captopril
  • Captopril; Hydrochlorothiazide, HCTZ
  • Enalapril, Enalaprilat
  • Enalapril; Felodipine
  • Enalapril; Hydrochlorothiazide, HCTZ
  • Fosinopril
  • Fosinopril; Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ; Lisinopril
  • Hydrochlorothiazide, HCTZ; Moexipril
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Lisinopril
  • Moexipril
  • Perindopril
  • Perindopril; Amlodipine
  • Quinapril
  • Ramipril
  • Trandolapril
  • Trandolapril; Verapamil
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