Icosapent ethyl

Icosapent ethyl Brand Name– VASCEPA

What is Icosapent ethyl

Icosapent ethyl is an ethyl ester of the omega-3 fatty acid eicosapentaenoic acid (EPA).

It is approved as an adjunct to diet to reduce triglyceride concentrations in adult patients with hypertriglyceridemia (500 mg/dL or greater) and as an adjunct to maximally tolerated statin therapy to reduce the risk of myocardial infarction, stroke, coronary revascularization, and unstable angina requiring hospitalization in adult patients with elevated triglyceride levels of 150 mg/dL or greater.

In a randomized, placebo-controlled, double-blind, parallel-group study of adult patients with baseline triglyceride levels between 500 and 2,000 mg/dL, administration of icosapent ethyl resulted in a 27%, 20%, and 4% reduction in the concentrations of median triglycerides (TG), very low-density lipoproteins (VLDL), and apolipoprotein-B (Apo B), respectively.

Icosapent ethyl was not associated with an elevation in LDL-C relative to placebo. In a randomized, multicenter, double-blind, placebo-controlled study of adult on patients on statin therapy with established cardiovascular disease or diabetes and other risk factors, icosapent ethyl was found to significantly reduced the risk for time to first occurrence of cardiovascular death, myocardial infarction, stroke, coronary revascularization, or hospitalization for unstable angina (p less than 0.0001).

The effect of icosapent ethyl on cardiovascular morbidity and mortality or the risk for pancreatitis in patients with severe hypertriglyceridemia has not been determined.

Icosapent ethyl was FDA-approved in July 2012.

Indications

  • hypertriglyceridemia
  • myocardial infarction prophylaxis
  • stroke prophylaxis

For use as an adjunct to diet to reduce triglycerides in adults with severe hypertriglyceridemia (triglyceride blood concentrations 500 mg/dL or more); or for use as an adjunct to maximally tolerated statin therapy in patients with a triglyceride concentration more than 150 mg/dL plus established cardiovascular (CV) disease or diabetes plus at least 2 additional CV risk factors to reduce the risk of CV events (i.e., myocardial infarction prophylaxis, stroke prophylaxis, coronary revascularization, unstable angina requiring hospitalization)

Side Effects

  1. arthralgia
  2. atrial fibrillation
  3. atrial flutter
  4. bleeding
  5. constipation
  6. ecchymosis
  7. epistaxis
  8. gout
  9. musculoskeletal pain
  10. peripheral edema
  11. prolonged bleeding time

Monitoring Parameters

  • serum triglycerides

Contraindications

  • anticoagulant therapy
  • atrial fibrillation
  • atrial flutter
  • bleeding
  • breast-feeding
  • children
  • fish hypersensitivity
  • hepatic disease
  • infants
  • neonates
  • pregnancy

Interactions

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