Ibutilide

Ibutilide Brand Name– Corvert

What is Ibutilide

Ibutilide a substituted methane sulfonamide derivative, is an intravenous Class III antiarrhythmic agent indicated for rapid conversion of atrial fibrillation or atrial flutter to normal sinus rhythm.

Prior to approval of ibutilide, electrical cardioversion was the recommended choice for rapid conversion of atrial fibrillation or flutter to normal sinus rhythm.

No other approved pharmacologic agent is indicated for rapid conversion of atrial arrhythmias.

Ibutilide began the FDA approval process in October 1994 and was finally approved December 28, 1995.

Application to market the drug in Sweden and England has also been made.

Indications

  • atrial fibrillation
  • atrial flutter

For the rapid cardioversion of recent onset atrial fibrillation or atrial flutter

Side Effects

  1. arrhythmia exacerbation
  2. AV block
  3. bradycardia
  4. bundle-branch block
  5. headache
  6. heart failure
  7. hypotension
  8. nausea
  9. orthostatic hypotension
  10. palpitations
  11. QT prolongation
  12. renal failure (unspecified)
  13. sinus tachycardia
  14. syncope
  15. torsade de pointes
  16. ventricular tachycardia

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • apheresis
  • AV block
  • bradycardia
  • breast-feeding
  • cardiomyopathy
  • celiac disease
  • children
  • females
  • fever
  • geriatric
  • heart failure
  • hepatic disease
  • human immunodeficiency virus (HIV) infection
  • hyperparathyroidism
  • hypocalcemia
  • hypokalemia
  • hypomagnesemia
  • hypothermia
  • hypothyroidism
  • infants
  • long QT syndrome
  • myocardial infarction
  • pheochromocytoma
  • pregnancy
  • QT prolongation
  • requires a specialized care setting
  • requires an experienced clinician
  • rheumatoid arthritis
  • sickle cell disease
  • sleep deprivation
  • stroke
  • systemic lupus erythematosus (SLE)
  • ventricular arrhythmias
  • ventricular dysfunction
  • ventricular tachycardia

Interactions

  • Abarelix
  • Alfuzosin
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  • Amitriptyline
  • Amitriptyline; Chlordiazepoxide
  • Amoxicillin; Clarithromycin; Lansoprazole
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  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Bretylium
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  • Ceritinib
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  • Class IA Antiarrhythmics
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  • Codeine; Promethazine
  • Crizotinib
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