Hydroxypropyl Cellulose

Hydroxypropyl Cellulose Brand Name– Lacrisert

What is Hydroxypropyl Cellulose

Hydroxypropyl cellulose is an ophthalmic insert used to reduce signs and symptoms resulting from moderate to severe dry eye syndromes.

The drug acts by stabilizing and thickening the precorneal tear film and prolonging the tear film breakup time. Instruct patients on proper placement of the ophthalmic inserts.

Patients should read the instructions and practice placement and removal of the inserts while in the health care provider’s office. Improper placement of the inserts may result in corneal abrasions.

The ophthalmic inserts may cause temporary blurred vision; caution patients regarding driving or operating machinery while receiving hydroxypropyl cellulose.

Indications

  1. keratitis
  2. keratoconjunctivitis
  3. xerophthalmia

For the treatment of moderate to severe dry eye syndromes (xerophthalmia) including keratoconjunctivitis sicca, exposure keratitis, decreased corneal sensitivity, and recurrent corneal erosions

Side Effects

  1. blurred vision
  2. edema
  3. hyperemia
  4. ocular irritation
  5. photophobia

Most adverse reactions associated with the use of hydroxypropyl cellulose ophthalmic inserts were mild and transient and included blurred vision, ocular irritation or discomfort, matting or stickiness of eyelashes, hypersensitivity, photophobia, edema of the eyelids, and hyperemia. If improperly inserted, corneal abrasion may occur.

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • breast-feeding
  • corneal abrasion
  • driving or operating machinery
  • pregnancy

Interactions

There are no drug interactions associated with Hydroxypropyl Cellulose products.

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