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Hydrocortisone Pramoxine Brand Names
Analpram E | Analpram HC | EndaRoid | Enzone | Epifoam | HC Pram | Mezparox-HC | Mezparox-HC Forte | Novacort | Paramox-HC | PramCort | PRAM-HCA | Pramosone | Pramosone E | ProCort | Proctocream-HC | ProctoFoam HC | Zone A | Zone A Forte | Z-Pram
What is Hydrocortisone Pramoxine
Hydrocortisone and pramoxine are combined and used topically for the treatment of inflamed and pruritic skin.
Hydrocortisone is a glucocorticoid that has antiinflammatory, antipruritic, and vasoconstrictive properties; pramoxine is a topical anesthetic that provides relief of pain and itching.
Hydrocortisone pramoxine products are typically used for the relief of inflammation, pain and pruritus associated with perianal and rectal skin disorders, such as hemorrhoids, post-episiotomy healing, anal fissures, and other corticosteroid-responsive dermatoses.
Several different formulations are available, including topical cream, lotion and ointment and aerosol foams for topical or rectal use.
Indications
- anal fissures
- dermatitis
- hemorrhoids
- proctitis
- pruritus
- psoriasis
- skin inflammation
- ulcerative colitis
For the temporary relief of skin inflammation, pain, and pruritus associated with corticosteroid-responsive dermatitis, including psoriasis, anorectal inflammation, pain, pruritus, and swelling associated with hemorrhoids, proctitis, cryptitis, anal fissures, postoperative pain, and pruritus ani
Side Effects
- acneiform rash
- anaphylactoid reactions
- bleeding
- bronchospasm
- contact dermatitis
- Cushing’s syndrome
- edema
- erythema
- glycosuria
- hyperesthesia
- hyperglycemia
- hypertrichosis
- hypothalamic-pituitary-adrenal (HPA) suppression
- infection
- miliaria
- pruritus
- purpura
- skin atrophy
- skin hypopigmentation
- skin irritation
- striae
- urticaria
- xerosis
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- breast-feeding
- cataracts
- children
- diabetes mellitus
- fistula
- fungal infection
- geriatric
- GI obstruction
- GI perforation
- glaucoma
- hepatic disease
- herpes infection
- hypothalamic-pituitary-adrenal (HPA) suppression
- infants
- infection
- neonates
- occlusive dressing
- ocular exposure
- ophthalmic administration
- peripheral vascular disease
- peritonitis
- pregnancy
- skin abrasion
- skin atrophy
- tuberculosis
- ulcerative colitis
- viral infection
Interactions
- Adapalene; Benzoyl Peroxide
- Benzocaine
- Benzocaine; Butamben; Tetracaine
- Benzoyl Peroxide
- Benzoyl Peroxide; Clindamycin
- Benzoyl Peroxide; Erythromycin
- Benzoyl Peroxide; Sulfur
- Dibucaine
- Ethyl Chloride
- Hydrocortisone; Lidocaine
- Lidocaine
- Lidocaine; Prilocaine
- Lidocaine; Tetracaine
- Tetracaine
Pramoxine is a local anesthetic that works by blocking nerve signals in the skin, providing temporary relief from itching and pain. Its mechanism of action involves inhibiting the conduction of nerve impulses along sensory nerve fibers.
When pramoxine is applied topically to the skin or mucous membranes, it binds to and blocks voltage-gated sodium channels in the nerve endings. These sodium channels are responsible for the propagation of nerve signals, including those associated with itching and pain sensations.
By blocking the sodium channels, pramoxine prevents the influx of sodium ions into the nerve cells, which inhibits the depolarization and subsequent transmission of nerve signals. This effectively reduces the sensation of itching and pain in the affected area.
It’s important to note that pramoxine is a surface or local anesthetic, meaning it primarily acts on the nerve endings at the site of application and does not have systemic effects. It provides temporary relief and does not treat the underlying cause of itching or pain. Therefore, it is often used in combination with other medications or treatments to manage symptoms.
Pramoxine is commonly found in over-the-counter topical creams, ointments, and sprays for various skin conditions, such as insect bites, minor burns, sunburn, dermatitis, and hemorrhoids. It is generally well-tolerated when used as directed, but it is important to follow the instructions provided and consult with a healthcare professional if you have any concerns or questions about its use.
