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Hydrocodone Potassium Guaiacolsulfonate Pseudoephedrine Brand Names
Hydro-Pro-D | Pro Cof D | Protuss D
What is Hydrocodone Potassium Guaiacolsulfonate Pseudoephedrine
NOTE: These products are discontinued in the U.S.
Hydrocodone potassium guaiacolsulfonate pseudoephedrine are used together in an oral preparation to relieve cough and to facilitate bronchial and sinus drainage.
Specifically, this combination is indicated for the relief of nasal congestion and dry, non-productive cough associated with the common cold, pertussis, or influenza. Hydrocodone, similar to codeine, is an opiate antitussive used for cough suppression.
The antitussive and sedative properties of hydrocodone are greater than codeine. Hydrocodone also has analgesic properties, although it is not used for this purpose when combined with potassium guaiacolsulfonate and pseudoephedrine.
Potassium guaiacolsulfonate has historically been used as an oral expectorant and is thought to be useful for a dry, non-productive cough which tends to injure the respiratory mucous membranes.
Although efficacy is not proven, potassium guaiacolsulfonate is used to loosen and thin sputum and bronchial secretions and to ease expectoration. Although this action can decrease secretions, indirectly diminishing the tendency to cough, potassium guaiacolsulfonate is not considered an antitussive agent.
Pseudoephedrine is a sympathomimetic agent that stimulates alpha1-adrenergic receptors in vascular smooth muscle.
This causes vasoconstriction, resulting in shrinkage of nasal mucous membranes, reduction of tissue hyperemia and edema, and an increase in nasal airway patency leading to decreased congestion.
Indications
- cough
- nasal congestion
For the temporary relief of dry, non-productive cough and nasal congestion due to minor throat and bronchial irritation as may occur with the common cold, pertussis, or influenza
Side Effects
- abdominal pain
- amenorrhea
- angina
- anorexia
- anxiety
- arrhythmia exacerbation
- biliary obstruction
- blurred vision
- bradycardia
- colitis
- confusion
- constipation
- contact dermatitis
- diaphoresis
- diarrhea
- dizziness
- drowsiness
- dysphoria
- dysuria
- erythema
- euphoria
- flushing
- gastritis
- hallucinations
- headache
- hyperamylasemia
- hypertension
- hyponatremia
- hypotension
- infertility
- insomnia
- libido decrease
- miosis
- myocardial infarction
- nausea
- neonatal abstinence syndrome
- ocular hypertension
- orthostatic hypotension
- palpitations
- photophobia
- physiological dependence
- premature ventricular contractions (PVCs)
- pruritus
- psychosis
- rash
- respiratory depression
- restlessness
- seizures
- SIADH
- sinus tachycardia
- stroke
- supraventricular tachycardia (SVT)
- syncope
- urinary retention
- vomiting
- withdrawal
- xerostomia
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- abrupt discontinuation
- acute bronchospasm
- alcoholism
- angina
- asthma
- bladder obstruction
- breast-feeding
- cardiac disease
- children
- chronic obstructive pulmonary disease (COPD)
- closed-angle glaucoma
- constipation
- coronary artery disease
- diabetes mellitus
- driving or operating machinery
- ethanol ingestion
- geriatric
- head trauma
- hepatic disease
- hypertension
- hyperthyroidism
- ileus
- increased intracranial pressure
- infants
- MAOI therapy
- neonatal opioid withdrawal syndrome
- neonates
- opiate agonist hypersensitivity
- orthostatic hypotension
- peripheral vascular disease
- pregnancy
- prostatic hypertrophy
- renal failure
- renal impairment
- respiratory depression
- respiratory insufficiency
- seizures
- sleep apnea
- substance abuse
- thyrotoxicosis
- urinary retention
Interactions
- Abiraterone
- Acarbose
- Acebutolol
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Diphenhydramine
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
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- Acrivastine; Pseudoephedrine
- Albiglutide
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- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
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- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
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- Sorbitol
- Sotalol
- Spironolactone
- St. John’s Wort, Hypericum perforatum
- Streptogramins
- Sufentanil
- Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
- Sulfonylureas
- Sulindac
- Sumatriptan
- Suvorexant
- Tacrolimus
- Tapentadol
- Tasimelteon
- Tazemetostat
- Tedizolid
- Telaprevir
- Telithromycin
- Telmisartan
- Telotristat Ethyl
- Temazepam
- Terbinafine
- Terbutaline
- Tetrabenazine
- Tetracaine
- Tezacaftor; Ivacaftor
- Thalidomide
- Theophylline, Aminophylline
- Thiazide diuretics
- Thiazolidinediones
- Thiopental
- Thioridazine
- Thiothixene
- Thyroid hormones
- Ticagrelor
- Timolol
- Tipranavir
- Tizanidine
- Tolmetin
- Tolterodine
- Topiramate
- Torsemide
- Tramadol
- Trandolapril
- Trandolapril; Verapamil
- Tranylcypromine
- Trazodone
- Treprostinil
- Triamcinolone
- Triamterene
- Triazolam
- Tricyclic antidepressants
- Trifluoperazine
- Trihexyphenidyl
- Trimethobenzamide
- Trimethoprim
- Triprolidine
- Trospium
- Tucatinib
- Umeclidinium; Vilanterol
- Valdecoxib
- Valerian, Valeriana officinalis
- Valproic Acid, Divalproex Sodium
- Valsartan
- Vasodilators
- Vasopressors
- Vemurafenib
- Venlafaxine
- Verapamil
- Vigabatrin
- Vilazodone
- Voriconazole
- Vortioxetine
- Voxelotor
- Yohimbine
- Zafirlukast
- Zaleplon
- Ziconotide
- Ziprasidone
- Zolmitriptan
- Zolpidem
