Histrelin

Histrelin Brand Names- Supprelin | Vantas

What is Histrelin

Histrelin acetate is a synthetic nonapeptide analog of gonadotropin releasing hormone (GnRH); the implant is a sterile, non-biodegradable, diffusion-controlled hydrogel polymer reservoir.

Histrelin functions as a GnRH agonist, and is a potent inhibitor of gonadotropin secretion when given continuously at therapeutic doses.

It is FDA approved for the palliative treatment of advanced prostate cancer and for the treatment of central precocious puberty. Initial transient increases of estradiol and/or testosterone may cause a temporary worsening of symptoms.

However, testosterone concentrations in men being treated for advanced prostate cancer are reduced to castration levels within 2 to 4 weeks of starting therapy. In pediatric patients, LH levels decrease to prepubertal levels within 1 month of treatment, with a resultant decrease in the serum concentrations of sex steroids (i.e., estrogen or testosterone). Implant insertion is a surgical procedure.

Indications

  • precocious puberty
  • prostate cancer

For the palliative treatment of advanced prostate cancer

Side Effects

  1. abdominal pain
  2. amblyopia
  3. anaphylactoid reactions
  4. anemia
  5. appetite stimulation
  6. arthralgia
  7. back pain
  8. bone pain
  9. breast enlargement
  10. constipation
  11. depression
  12. diabetes mellitus
  13. diaphoresis
  14. dizziness
  15. dysmenorrhea
  16. dyspnea
  17. dysuria
  18. ecchymosis
  19. edema
  20. elevated hepatic enzymes
  21. emotional lability
  22. epistaxis
  23. erythema
  24. fatigue
  25. flushing
  26. gynecomastia
  27. headache
  28. hematoma
  29. hematuria
  30. hot flashes
  31. hot flashes
  32. hypercalcemia
  33. hypercholesterolemia
  34. hyperglycemia
  35. hyperhidrosis
  36. hypertrichosis
  37. impotence (erectile dysfunction)
  38. increased urinary frequency
  39. infection
  40. influenza
  41. injection site reaction
  42. insomnia
  43. irritability
  44. lethargy
  45. libido decrease
  46. malaise
  47. menorrhagia
  48. migraine
  49. myalgia
  50. myocardial infarction
  51. nausea
  52. neuropathic pain
  53. night sweats
  54. osteopenia
  55. osteoporosis
  56. palpitations
  57. pituitary apoplexy
  58. pruritus
  59. QT prolongation
  60. renal failure (unspecified)
  61. seizures
  62. spinal cord compression
  63. stroke
  64. suicidal ideation
  65. testicular atrophy
  66. tremor
  67. tumor flare
  68. urinary retention
  69. vaginal bleeding
  70. visual impairment
  71. vomiting
  72. weakness
  73. weight gain
  74. weight loss

Monitoring Parameters

  • blood glucose
  • ECG
  • glycosylated hemoglobin A1c (HbA1c)
  • prostate-specific antigen (PSA)
  • serum electrolytes
  • serum estradiol concentrations
  • serum gonadotropin concentrations
  • serum testosterone concentrations

Contraindications

  • apheresis
  • AV block
  • bladder obstruction
  • bradycardia
  • breast-feeding
  • cardiac disease
  • cardiomyopathy
  • celiac disease
  • children
  • depression
  • diabetes mellitus
  • electrolyte imbalance
  • females
  • fever
  • geriatric
  • Gonadotropin-Releasing Hormone (GnRH) analogs hypersensitivity
  • heart failure
  • human immunodeficiency virus (HIV) infection
  • hyperglycemia
  • hyperparathyroidism
  • hypocalcemia
  • hypokalemia
  • hypomagnesemia
  • hypothermia
  • hypothyroidism
  • infants
  • long QT syndrome
  • myocardial infarction
  • neonates
  • osteoporosis
  • pheochromocytoma
  • pituitary insufficiency
  • pregnancy
  • QT prolongation
  • renal impairment
  • rheumatoid arthritis
  • seizure disorder
  • sickle cell disease
  • sleep deprivation
  • spinal cord compression
  • stroke
  • suicidal ideation
  • systemic lupus erythematosus (SLE)
  • urinary tract obstruction

Interactions

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