Histamine Dihydrochloride

What is Histamine Dihydrochloride

Histamine dihydrochloride is a topical analgesic used for minor aches and pains of muscles and joints. It is also being researched as an orphan drug for the adjunctive treatment of acute myeloid leukemia or malignant melanoma

Histamine is a biological mediator used in physiological and pathological processes.

Histamine plays an important role in inflammation, gastric acid secretion, immune responses, smooth muscle contractions and as a neurotransmitter. Endogenous histamine is synthesized in all tissues and is stored primarily in the granules of mast cells or basophils.

Historically histamine is best known as a mediator of allergic reactions and inflammation, but it’s function as a immunostimulant is being further investigated.


  1. arthralgia
  2. mild pain
  3. myalgia

For the treatment of mild aches and mild pain of muscles (myalgia) and joints (arthralgia) associated with arthritis, uncomplicated backaches, strains, and bruises

Side Effects

  • rash

If a rash (unspecified) occurs while using histamine dihydrochloride, discontinue use and consult your healthcare professional

Monitoring Parameters

  • laboratory monitoring not necessary


  • breast-feeding
  • heating pad
  • ocular exposure
  • ophthalmic administration
  • pregnancy
  • skin abrasion


There are no drug interactions associated with Histamine Dihydrochloride products.

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