Tioconazole

What is Tioconazole

Tioconazole is an imidazole antifungal agent available for intravaginal use.

Tioconazole is fungicidal against Candida sp. and is used to treat vulvovaginal candidiasis.

It is approved as a single-dose treatment for vulvovaginal candidiasis.

Tioconazole was approved by the FDA in 1983 and was originally available only as a prescription product.

In 1996, tioconazole was reclassified as a nonprescription drug.

Indications

  1. Candida albicans
  2. Candida glabrata
  3. Candida guilliermondii
  4. Candida kefyr
  5. Candida krusei
  6. Candida parapsilosis
  7. Candida pseudotropicalis
  8. Candida sp.
  9. Candida stellatoidea
  10. Candida tropicalis
  11. vulvovaginal candidiasis

Side Effects

  1. contact dermatitis
  2. dyspareunia
  3. dysuria
  4. nocturia
  5. pruritus
  6. vaginal irritation
  7. vaginal pain

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • abdominal pain
  • azole antifungals hypersensitivity
  • breast-feeding
  • children
  • contraceptive devices
  • fever
  • human immunodeficiency virus (HIV) infection
  • immunosuppression
  • infants
  • infection
  • menstruation
  • neonates
  • ocular exposure
  • pain
  • pregnancy
  • vomiting

Interactions

There are no drug interactions associated with Tioconazole products.

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