Halobetasol

Halobetasol Brand Names- BRYHALI | LEXETTE | Ultravate

What is Halobetasol

Halobetasol is a very high potency, topical, fluorinated corticosteroid.

Halobetasol is used to relieve the inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses and psoriasis.

Very high potency topical corticosteroids are used as an alternative to systemic therapy for localized conditions.

Long-term or extensive use can lead to systemic side effects, including hypothalamic-pituitary-adrenal (HPA) axis suppression.

Comparative studies with other very high potency corticosteroids, such as clobetasol or betamethasone dipropionate have shown similar results in the treatment of atopic dermatitis and plaque-type psoriasis.

Combination regimens using calcipotriene and halobetasol have been effective for the treatment of psoriasis.

Indications

  1. alopecia
  2. atopic dermatitis
  3. contact dermatitis
  4. cutaneous T-cell lymphoma (CTCL)
  5. dermatitis
  6. discoid lupus erythematosus
  7. eczema
  8. exfoliative dermatitis
  9. granuloma annulare
  10. keloids
  11. lichen planus
  12. lichen simplex
  13. lichen striatus
  14. mycosis fungoides
  15. necrobiosis lipoidica diabeticorum
  16. pityriasis rosea
  17. pompholyx
  18. prurigo
  19. pruritus
  20. psoriasis
  21. Rhus dermatitis
  22. urticaria

Side Effects

  1. acneiform rash
  2. adrenocortical insufficiency
  3. cataracts
  4. contact dermatitis
  5. Cushing’s syndrome
  6. erythema
  7. folliculitis
  8. glycosuria
  9. growth inhibition
  10. headache
  11. hyperglycemia
  12. hypertension
  13. hypertrichosis
  14. hypothalamic-pituitary-adrenal (HPA) suppression
  15. impaired wound healing
  16. increased intracranial pressure
  17. infection
  18. influenza
  19. maculopapular rash
  20. miliaria
  21. ocular hypertension
  22. papilledema
  23. paresthesias
  24. pharyngitis
  25. pruritus
  26. pseudotumor cerebri
  27. purpura
  28. rash
  29. skin atrophy
  30. skin hypopigmentation
  31. skin irritation
  32. skin ulcer
  33. striae
  34. telangiectasia
  35. tolerance
  36. visual impairment
  37. withdrawal
  38. xerosis

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • acne rosacea
  • acne vulgaris
  • breast-feeding
  • cataracts
  • children
  • corticosteroid hypersensitivity
  • Cushing’s syndrome
  • diabetes mellitus
  • fungal infection
  • geriatric
  • glaucoma
  • growth inhibition
  • herpes infection
  • hypothalamic-pituitary-adrenal (HPA) suppression
  • increased intracranial pressure
  • infants
  • infection
  • measles
  • neonates
  • occlusive dressing
  • ocular exposure
  • perioral dermatitis
  • peripheral vascular disease
  • pregnancy
  • skin abrasion
  • skin atrophy
  • tobacco smoking
  • tuberculosis
  • varicella
  • viral infection

Interactions

There are no drug interactions associated with Halobetasol products.

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