Halobetasol Tazarotene

Halobetasol Tazarotene Brand Name– Duobrii

What is Halobetasol Tazarotene

Halobetasol tazarotene is a topical product that combines a very high potency, fluorinated corticosteroid with a retinoid to treat plaque psoriasis in adults.

The drug is dosed once daily, and should not be applied to the face, groin, or in the axillae. Long-term or extensive use may lead to systemic side effects, including hypothalamic-pituitary-adrenal (HPA) axis suppression.

Halobetasol tazarotene is contraindicated for use during pregnancy; females of childbearing potential should undergo pregnancy testing within 2 weeks of initiating treatment, and use adequate birth control during treatment.

Indications

  • psoriasis

General Comparative Topical Corticosteroid Potency:

NOTE: The following is a general representation. Check specific product formulations prior to making potency decisions.

Very High Potency

Betamethasone dipropionate (augmented)

Clobetasol

Diflorasone diacetate ointment

Halobetasol

High Potency

Amcinonide

Betamethasone dipropionate

Desoximetasone gel or ointment, or cream 0.25% or more

Diflorasone diacetate cream

Fluocinolone cream 0.2% or more

Fluocinonide

Halcinonide

Triamcinolone 0.5% or more

Medium Potency

Beclomethasone

Betamethasone benzoate

Betamethasone valerate

Clobetasone

Desoximetasone cream less than 0.25%

Diflucortolone

Fluocinolone ointment or topical solution or cream less than 0.2%

Flurandrenolide 0.025% or more

Fluticasone

Hydrocortisone butyrate

Hydrocortisone valerate

Mometasone

Prednicarbate

Triamcinolone less than 0.5%

Low Potency

Alclometasone

Clocortolone

Desonide

Dexamethasone

Flumethasone

Flurandrenolide less than 0.025%

Hydrocortisone base

Hydrocortisone acetate

Side Effects

  1. adrenocortical insufficiency
  2. cataracts
  3. contact dermatitis
  4. Cushing’s syndrome
  5. folliculitis
  6. glycosuria
  7. growth inhibition
  8. headache
  9. hyperglycemia
  10. hypothalamic-pituitary-adrenal (HPA) suppression
  11. impaired wound healing
  12. increased intracranial pressure
  13. ocular hypertension
  14. papilledema
  15. photosensitivity
  16. pseudotumor cerebri
  17. rash
  18. skin atrophy
  19. striae
  20. telangiectasia
  21. visual impairment

Monitoring Parameters

  • pregnancy testing

Contraindications

  • accidental exposure
  • breast-feeding
  • cataracts
  • children
  • contraception requirements
  • Cushing’s syndrome
  • diabetes mellitus
  • eczema
  • females
  • glaucoma
  • growth inhibition
  • hepatic disease
  • hypothalamic-pituitary-adrenal (HPA) suppression
  • increased intracranial pressure
  • infants
  • neonates
  • occlusive dressing
  • ocular exposure
  • pregnancy
  • pregnancy testing
  • skin abrasion
  • skin photosensitivity disorder
  • sunburn
  • sunlight (UV) exposure

Interactions

  • Acetohexamide
  • Adapalene; Benzoyl Peroxide
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Amiloride; Hydrochlorothiazide, HCTZ
  • Aminolevulinic Acid
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Atenolol; Chlorthalidone
  • Azilsartan; Chlorthalidone
  • Benazepril; Hydrochlorothiazide, HCTZ
  • Bendroflumethiazide; Nadolol
  • Benzoyl Peroxide
  • Benzoyl Peroxide; Clindamycin
  • Benzoyl Peroxide; Erythromycin
  • Benzoyl Peroxide; Sulfur
  • Bisoprolol; Hydrochlorothiazide, HCTZ
  • Candesartan; Hydrochlorothiazide, HCTZ
  • Captopril; Hydrochlorothiazide, HCTZ
  • Chlorothiazide
  • Chlorpromazine
  • Chlorpropamide
  • Chlorthalidone
  • Chlorthalidone; Clonidine
  • Ciprofloxacin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • Dextromethorphan; Promethazine
  • Enalapril; Hydrochlorothiazide, HCTZ
  • Eprosartan; Hydrochlorothiazide, HCTZ
  • Fluphenazine
  • Fosinopril; Hydrochlorothiazide, HCTZ
  • Gemifloxacin
  • Glimepiride
  • Glimepiride; Pioglitazone
  • Glimepiride; Rosiglitazone
  • Glipizide
  • Glipizide; Metformin
  • Glyburide
  • Glyburide; Metformin
  • Griseofulvin
  • Hydralazine; Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ; Irbesartan
  • Hydrochlorothiazide, HCTZ; Lisinopril
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Moexipril
  • Hydrochlorothiazide, HCTZ; Olmesartan
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Hydrochlorothiazide, HCTZ; Telmisartan
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Indapamide
  • Levofloxacin
  • Meperidine; Promethazine
  • Mesoridazine
  • Methyclothiazide
  • Metolazone
  • Moxifloxacin
  • Norfloxacin
  • Ofloxacin
  • Perphenazine
  • Perphenazine; Amitriptyline
  • Phenothiazines
  • Phenylephrine; Promethazine
  • Photosensitizing agents (topical)
  • Prochlorperazine
  • Promethazine
  • St. John’s Wort, Hypericum perforatum
  • Sulfonylureas
  • Tetracyclines
  • Thiazide diuretics
  • Thiethylperazine
  • Thioridazine
  • Tolazamide
  • Tolbutamide
  • Trifluoperazine
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