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Gilteritinib Brand Name– XOSPATA
What is Gilteritinib
Gilteritinib is an oral tyrosine kinase inhibitor that inhibits mutant FLT3.
It is indicated for the treatment of relapsed or refractory FLT3 mutation-positive acute myelogenous leukemia as detected by an FDA-approved test.
Differentiation syndrome, posterior reversible encephalopathy syndrome, pancreatitis, and QT prolongation has been reported with gilteritinib therapy.
Indications
- acute myelogenous leukemia (AML)
For the treatment of acute myelogenous leukemia (AML)
NOTE: Gilteritinib has been designated an orphan drug by the FDA for the treatment of AML.
for the treatment of relapsed or refractory FLT3 mutation-positive AML
Side Effects
- abdominal pain
- acne vulgaris
- acneiform rash
- anaphylactoid reactions
- angioedema
- arthralgia
- arthralgia
- asthenia
- back pain
- bone pain
- bullous rash
- cardiac arrest
- cardiomyopathy
- colitis
- constipation
- constipation
- contact dermatitis
- cough
- cough
- diarrhea
- differentiation syndrome
- dizziness
- dysgeusia
- dyspnea
- dyspnea
- edema
- edema
- elevated hepatic enzymes
- elevated hepatic enzymes
- encephalopathy
- erythema
- erythema
- erythema multiforme
- exfoliative dermatitis
- fatigue
- fatigue
- fever
- fever
- GI perforation
- headache
- heart failure
- hepatotoxicity
- hyperamylasemia
- hyperesthesia
- hyperkeratosis
- hypertriglyceridemia
- hypocalcemia
- hypoesthesia
- hyponatremia
- hypophosphatemia
- hypotension
- hypotension
- hypoxia
- infection
- insomnia
- lethargy
- leukocytosis
- maculopapular rash
- malaise
- malaise
- muscle cramps
- musculoskeletal pain
- myalgia
- myalgia
- myocarditis
- nausea
- nephrotoxicity
- neutropenia
- oral ulceration
- oral ulceration
- palmar-plantar erythrodysesthesia (hand and foot syndrome)
- pancreatitis
- paresthesias
- peptic ulcer
- pericardial effusion
- pericarditis
- peripheral edema
- peripheral neuropathy
- pleural effusion
- QT prolongation
- rash
- rash
- seizures
- skin hyperpigmentation
- skin ulcer
- stomatitis
- urticaria
- vomiting
- weight gain
Monitoring Parameters
- CBC with differential
- creatine phosphokinase (CPK)
- ECG
- pregnancy testing
- serum electrolytes
Contraindications
- apheresis
- arthralgia
- AV block
- bradycardia
- breast-feeding
- cardiomyopathy
- celiac disease
- contraception requirements
- differentiation syndrome
- electrolyte imbalance
- females
- fever
- geriatric
- heart failure
- hepatotoxicity
- human immunodeficiency virus (HIV) infection
- hyperparathyroidism
- hypocalcemia
- hypokalemia
- hypomagnesemia
- hypothermia
- hypothyroidism
- long QT syndrome
- male-mediated teratogenicity
- myocardial infarction
- pheochromocytoma
- pregnancy
- pregnancy testing
- QT prolongation
- renal impairment
- reproductive risk
- rheumatoid arthritis
- sickle cell disease
- sleep deprivation
- stroke
- systemic lupus erythematosus (SLE)
Interactions
- Aclidinium; Formoterol
- Albuterol
- Albuterol; Ipratropium
- Alfuzosin
- Amiodarone
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Anagrelide
- Apalutamide
- Apomorphine
- Arformoterol
- Aripiprazole
- Arsenic Trioxide
- Artemether; Lumefantrine
- Asenapine
- Atazanavir
- Atazanavir; Cobicistat
- Atomoxetine
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Azithromycin
- Bedaquiline
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Budesonide; Formoterol
- Buprenorphine
- Buprenorphine; Naloxone
- Carbamazepine
- Ceritinib
- Chloramphenicol
- Chloroquine
- Chlorpromazine
- Ciprofloxacin
- Cisapride
- Citalopram
- Clarithromycin
- Clofazimine
- Clomipramine
- Clozapine
- Cobicistat
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Conivaptan
- Crizotinib
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Dasatinib
- Degarelix
- Delavirdine
- Desflurane
- Desipramine
- Deutetrabenazine
- Dextromethorphan; Promethazine
- Dextromethorphan; Quinidine
- Disopyramide
- Dofetilide
- Dolasetron
- Dolutegravir; Rilpivirine
- Donepezil
- Donepezil; Memantine
- Doxepin
- Dronedarone
- Droperidol
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Eliglustat
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Encorafenib
- Enflurane
- Entrectinib
- Eribulin
- Erythromycin
- Erythromycin; Sulfisoxazole
- Escitalopram
- Ezogabine
- Fingolimod
- Flecainide
- Fluconazole
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluphenazine
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Fluvoxamine
- Formoterol
- Formoterol; Mometasone
- Fosamprenavir
- Foscarnet
- Fosphenytoin
- Gemifloxacin
- Gemtuzumab Ozogamicin
- Glasdegib
- Glycopyrrolate; Formoterol
- Goserelin
- Granisetron
- grapefruit juice
- Halogenated Anesthetics
- Haloperidol
- Halothane
- Histrelin
- Hydroxychloroquine
- Hydroxyzine
- Ibutilide
- Idelalisib
- Iloperidone
- Imipramine
- Indacaterol
- Indacaterol; Glycopyrrolate
- Indinavir
- Inotuzumab Ozogamicin
- Isoflurane
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Itraconazole
- Ivosidenib
- Ketoconazole
- Lapatinib
- Lefamulin
- Lenvatinib
- Letermovir
- Leuprolide
- Leuprolide; Norethindrone
- Levalbuterol
- Levofloxacin
- Lithium
- Lofexidine
- Long-acting beta-agonists
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Macimorelin
- Maprotiline
- Mefloquine
- Meperidine; Promethazine
- Metaproterenol
- Methadone
- Metronidazole
- Midostaurin
- Mifepristone
- Mirtazapine
- Moxifloxacin
- Nefazodone
- Nelfinavir
- Nilotinib
- Norfloxacin
- Nortriptyline
- Octreotide
- Ofloxacin
- Olanzapine
- Olodaterol
- Ombitasvir; Paritaprevir; Ritonavir
- Ondansetron
- Osilodrostat
- Osimertinib
- Oxaliplatin
- Ozanimod
- Paliperidone
- Panobinostat
- Paroxetine
- Pasireotide
- Pazopanib
- Pentamidine
- Perphenazine
- Perphenazine; Amitriptyline
- Phenobarbital
- Phenylephrine; Promethazine
- Phenytoin
- Pimavanserin
- Pimozide
- Pirbuterol
- Pitolisant
- Posaconazole
- Primaquine
- Primidone
- Procainamide
- Prochlorperazine
- Promethazine
- Propafenone
- Protriptyline
- Quetiapine
- Quinidine
- Quinine
- Ranolazine
- Ribociclib
- Ribociclib; Letrozole
- Rifampin
- Rilpivirine
- Risperidone
- Ritonavir
- Romidepsin
- Salmeterol
- Saquinavir
- Selpercatinib
- Sertraline
- Sevoflurane
- Short-acting beta-agonists
- Siponimod
- Solifenacin
- Sorafenib
- Sotalol
- St. John’s Wort, Hypericum perforatum
- Sunitinib
- Tacrolimus
- Tamoxifen
- Telavancin
- Telithromycin
- Terbutaline
- Tetrabenazine
- Thioridazine
- Tiotropium; Olodaterol
- Tipranavir
- Tolterodine
- Toremifene
- Trazodone
- Triclabendazole
- Tricyclic antidepressants
- Trifluoperazine
- Trimipramine
- Triprolidine
- Triptorelin
- Tucatinib
- Umeclidinium; Vilanterol
- Vandetanib
- Vardenafil
- Vemurafenib
- Venlafaxine
- Voriconazole
- Vorinostat
- Ziprasidone
