Gadobutrol Brand Name– Gadavist
What is Gadobutrol
Gadobutrol is a paramagnetic, gadolinium-based contrast agent (GBCA) indicated for use during magnetic resonance imaging (MRI) to assess myocardial perfusion in patients with known or suspected coronary artery disease, assess the presence and extent of malignant breast disease, and detect and visualize areas with disrupted blood-brain barrier and/or abnormal vascularity within the central nervous system (CNS).
It is also used in magnetic resonance angiography (MRA) to evaluate known or suspected supra-aortic or renal artery disease.
Gadobutrol, like all GBCAs, carries a black box warning for nephrogenic systemic fibrosis (NSF).
NSF is a serious condition that may result in fatal or debilitating fibrosis of the skin, muscle, and internal organs.
The propensity to cause NSF differs among available GBCAs; few, if any, confirmed cases have been associated with gadobutrol while most unconfounded cases have been reported with gadodiamide, gadopentetate dimeglumine, and gadoversetamide.
Indications
- angiography
- magnetic resonance imaging (MRI)
For use with magnetic resonance imaging (MRI) to assess myocardial perfusion in patients with known or suspected coronary artery disease, assess the presence and extent of malignant breast disease, and detect and visualize areas with disrupted blood-brain barrier and/or abnormal vascularity within the central nervous system (CNS)
Side Effects
- anaphylactic shock
- anaphylactoid reactions
- angioedema
- bronchospasm
- cardiac arrest
- chest pain (unspecified)
- conjunctivitis
- cough
- cyanosis
- dizziness
- dysgeusia
- dyspnea
- erythema
- headache
- hyperhidrosis
- hypertension
- injection site reaction
- laryngeal edema
- maculopapular rash
- malaise
- nausea
- nephrogenic systemic fibrosis (nephrogenic fibrosing dermopathy)
- pallor
- palpitations
- paresthesias
- parosmia
- pruritus
- pulmonary edema
- rash
- renal failure (unspecified)
- respiratory arrest
- sinus tachycardia
- sneezing
- urticaria
- vomiting
- xerostomia
Monitoring Parameters
- serum creatinine/BUN
Contraindications
- aortic stenosis
- asthma
- atopy
- breast-feeding
- diabetes mellitus
- dialysis
- extravasation
- geriatric
- hypertension
- magnetic resonance imaging (MRI)
- nephrogenic systemic fibrosis (nephrogenic fibrosing dermopathy)
- pregnancy
- radiopaque contrast media hypersensitivity
- renal artery stenosis
- renal disease
- renal failure
- renal impairment
- sickle cell disease
Interactions
- Bictegravir; Emtricitabine; Tenofovir Alafenamide
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Tenofovir alafenamide
- Tenofovir Alafenamide
- Tenofovir Alafenamide