Gadobenate Dimeglumine

Gadobenate Dimeglumine Brand Name– Multihance

What is Gadobenate Dimeglumine

Gadobenate dimeglumine is a paramagnetic agent used during magnetic resonance imaging (MRI) for enhanced visualization of abnormal vascularity within the central nervous system or disruptions in the blood-brain barrier, and during magnetic resonance angiography (MRA) to evaluate occlusive disease within the renal and aorto-iliac-femoral vasculature.

Like all gadolinium-based contrast agents (GBCAs), gadobenate dimeglumine carries a black box warning for nephrogenic systemic fibrosis (NSF). NSF is a serious condition that may result in fatal or debilitating fibrosis of the skin, muscle, and internal organs.

The propensity to cause NSF differs among available GBCAs; few, if any, confirmed cases have been associated with gadobenate dimeglumine while most unconfounded cases have been reported with gadodiamide, gadopentetate dimeglumine, and gadoversetamide

Indications

  • angiography
  • magnetic resonance imaging (MRI)

For use as a contrast enhancement in magnetic resonance imaging (MRI) to visualize areas of the brain, spine, and associated tissues with disruption of the blood brain barrier or abnormal vascularity

Side Effects

  1. abdominal pain
  2. anaphylactoid reactions
  3. angioedema
  4. asthenia
  5. AV block
  6. cardiac arrest
  7. chest pain (unspecified)
  8. chills
  9. diarrhea
  10. dizziness
  11. dysgeusia
  12. fatigue
  13. fever
  14. headache
  15. hyperemia
  16. hyperhidrosis
  17. injection site reaction
  18. laryngospasm
  19. malaise
  20. nasal congestion
  21. nausea
  22. nephrogenic systemic fibrosis (nephrogenic fibrosing dermopathy)
  23. ocular inflammation
  24. ocular pruritus
  25. pancreatitis
  26. paresthesias
  27. parosmia
  28. pruritus
  29. pulmonary edema
  30. QT prolongation
  31. rash
  32. renal failure (unspecified)
  33. respiratory arrest
  34. sneezing
  35. tremor
  36. urticaria
  37. visual impairment
  38. vomiting
  39. wheezing
  40. xerostomia

Monitoring Parameters

  • serum creatinine/BUN

Contraindications

  • asthma
  • atopy
  • breast-feeding
  • cardiac arrhythmias
  • children
  • diabetes mellitus
  • dialysis
  • extravasation
  • geriatric
  • hypertension
  • infants
  • magnetic resonance imaging (MRI)
  • neonates
  • nephrogenic systemic fibrosis (nephrogenic fibrosing dermopathy)
  • pregnancy
  • QT prolongation
  • radiopaque contrast media hypersensitivity
  • renal disease
  • renal failure
  • renal impairment
  • sickle cell disease

Interactions

  • Anthracyclines
  • Cisplatin
  • Daunorubicin
  • Doxorubicin
  • Epirubicin
  • Etoposide, VP-16
  • Idarubicin
  • Methotrexate
  • Paclitaxel
  • Vinca alkaloids
You cannot copy content of this page