Gadodiamide

What is Gadodiamide

Gadodiamide is a nonionic, gadolinium-based paramagnetic contrast agent (GBCA) used during magnetic resonance imaging (MRI) to enhance visualization of abnormal vascularity within the central nervous system (CNS), thoracic, abdominal, or pelvic cavities, or the retroperitoneal space. Like all GBCAs, gadodiamide carries a black box warning for nephrogenic systemic fibrosis (NSF).

NSF is a serious condition that may result in fatal or debilitating fibrosis of the skin, muscle, and internal organs.

The propensity to cause NSF differs among available GBCAs; most unconfounded cases have been reported with gadodiamide, gadopentetate dimeglumine, and gadoversetamide.

Indications

  • magnetic resonance imaging (MRI)

For use with magnetic resonance imaging (MRI) to enhance visualization of lesions with abnormal vascularity within the central nervous system and body

Monitoring Parameters

  • serum creatinine/BUN

Contraindications

  • asthma
  • atopy
  • breast-feeding
  • children
  • diabetes mellitus
  • dialysis
  • geriatric
  • hypertension
  • infants
  • intrathecal administration
  • laboratory test interference
  • magnetic resonance imaging (MRI)
  • neonates
  • nephrogenic systemic fibrosis (nephrogenic fibrosing dermopathy)
  • pregnancy
  • radiopaque contrast media hypersensitivity
  • renal disease
  • renal failure
  • renal impairment
  • sickle cell disease

Interactions

There are no drug interactions associated with Gadodiamide products.