Furazolidone

Furazolidone Brand Name– Furoxone

What is Furazolidone

NOTE: This drug is discontinued in the US.

Furazolidone is an oral antiinfective agent, a derivative of nitrofuran, and a member of the oxazolidinone class. Furazolidone is active against a broad spectrum of gram-negative and gram-positive bacteria as well as protozoa such as Giardia lambia.

It is indicated in the treatment of bacterial or protozoal diarrhea and enteritis.

Furazolidone may be useful in treating acute infantile diarrhea, traveler’s diarrhea, cholera, typhoid fever, giardiasis, and bacteremic salmonellosis.

It is highly active in vitro against the various enteropathogens that cause infectious forms of diarrhea such as Vibrio parahaemolyticus, Salmonella species,Shigella species, enterotoxogenic Escherichia coli, Campylobacter jejuni, and Yersinia enterocolitica.

Furazolidone is also active against Vibrio cholerae, Giardia lamblia,Klebsiella species, Enterobacter species, Bacteriodes species, Proteus speciesStaphyloccocci species, and trichomonads.

Furazolidone is also structurally similar to monoamine oxidase inhibitors (MAOIs) and exhibits some non-selective MAOI activity. Furazolidone can cause a disulfuram-like reaction when taken concurrently with alcohol.

Furazolidone was approved by the FDA in 1955.

Indications

  1. Bacteroides sp.
  2. Campylobacter jejuni
  3. Enterobacter sp.
  4. Escherichia coli
  5. gastroenteritis
  6. Giardia lamblia
  7. giardiasis
  8. Helicobacter pylori
  9. Klebsiella sp.
  10. Proteus sp.
  11. Salmonella sp.
  12. Shigella sp.
  13. Staphylococcus sp.
  14. trichomoniasis
  15. Vibrio cholerae
  16. Vibrio parahaemolyticus
  17. Yersinia enterocolitica

Side Effects

  1. arthralgia
  2. fever
  3. headache
  4. hemolysis
  5. hemolytic anemia
  6. hypotension
  7. malaise
  8. nausea
  9. urine discoloration
  10. urticaria
  11. vesicular rash
  12. vomiting

Monitoring Parameters

  • hemoglobin/hematocrit

Contraindications

  • alcoholism
  • breast-feeding
  • children
  • diabetes mellitus
  • ethanol intoxication
  • G6PD deficiency
  • geriatric
  • hemolytic anemia
  • infants
  • MAOI therapy
  • neonates
  • orthostatic hypotension
  • pregnancy
  • syncope

Interactions

  • Bupivacaine; Lidocaine
  • Carbidopa; Levodopa
  • Carbidopa; Levodopa; Entacapone
  • Levodopa
  • Lidocaine
  • Lidocaine; Prilocaine
  • Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
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