Furosemide

Furosemide Brand Names- Delone | Lasix

What is Furosemide

Furosemide is a sulfonamide-derived loop diuretic used in the management of edema associated with congestive heart failure, cirrhosis, and renal disease, including the nephrotic syndrome.

Other uses include mild to moderate hypertension and as an adjunct in hypertensive crisis and acute pulmonary edema.

Furosemide is also useful in treating hypercalcemia, although it is not FDA approved for this indication.

Furosemide is effective in managing edema associated with congestive heart failure, and it may be useful in patients who are unresponsive to other diuretics or who have severe renal impairment.

Furosemide was approved by the FDA in 1966.

Indications

  1. ascites
  2. chronic lung disease (CLD)
  3. edema
  4. heart failure
  5. hypercalcemia
  6. hypertension
  7. hypertensive emergency
  8. hypertensive urgency
  9. nephrotic syndrome
  10. pulmonary edema
  11. renal impairment

For the treatment of peripheral edema or edema associated with heart failure, chronic lung disease (CLD), or nephrotic syndrome

Side Effects

  1. abdominal pain
  2. acute generalized exanthematous pustulosis (AGEP)
  3. agranulocytosis
  4. anaphylactic shock
  5. anaphylactoid reactions
  6. anemia
  7. anorexia
  8. aplastic anemia
  9. azotemia
  10. bladder spasm
  11. blurred vision
  12. bullous rash
  13. cholestasis
  14. constipation
  15. diabetes mellitus
  16. diarrhea
  17. dizziness
  18. Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
  19. elevated hepatic enzymes
  20. eosinophilia
  21. erythema multiforme
  22. exfoliative dermatitis
  23. fever
  24. glycosuria
  25. gout
  26. headache
  27. hearing loss
  28. hemolytic anemia
  29. hepatic encephalopathy
  30. hypercholesterolemia
  31. hyperglycemia
  32. hypertriglyceridemia
  33. hyperuricemia
  34. hypocalcemia
  35. hypochloremia
  36. hypokalemia
  37. hypomagnesemia
  38. hyponatremia
  39. hypovolemia
  40. injection site reaction
  41. interstitial nephritis
  42. jaundice
  43. leukopenia
  44. metabolic alkalosis
  45. muscle cramps
  46. nausea
  47. oliguria
  48. orthostatic hypotension
  49. pancreatitis
  50. paresthesias
  51. phlebitis
  52. photosensitivity
  53. polyuria
  54. pruritus
  55. purpura
  56. rash
  57. restlessness
  58. Stevens-Johnson syndrome
  59. syncope
  60. thrombocytopenia
  61. thromboembolism
  62. thrombosis
  63. tinnitus
  64. toxic epidermal necrolysis
  65. urticaria
  66. vasculitis
  67. vertigo
  68. vomiting
  69. weakness
  70. xanthopsia

Monitoring Parameters

  • audiometry
  • blood glucose
  • blood pressure
  • serum creatinine/BUN
  • serum electrolytes
  • serum uric acid

Contraindications

  • acid/base imbalance
  • acute myocardial infarction
  • anuria
  • ascites
  • breast-feeding
  • children
  • diabetes mellitus
  • diarrhea
  • electrolyte imbalance
  • geriatric
  • gout
  • hearing impairment
  • heart failure
  • hepatic disease
  • hepatic encephalopathy
  • hyperglycemia
  • hyperuricemia
  • hypocalcemia
  • hypochloremia
  • hypokalemia
  • hypomagnesemia
  • hyponatremia
  • hypotension
  • hypovolemia
  • infants
  • metabolic alkalosis
  • neonates
  • orthostatic hypotension
  • pancreatitis
  • pregnancy
  • premature neonates
  • prostatic hypertrophy
  • renal disease
  • renal failure
  • renal impairment
  • sulfonamide hypersensitivity
  • sympathectomy
  • syncope
  • systemic lupus erythematosus (SLE)
  • thiazide diuretic hypersensitivity
  • thyroid disease
  • urethral stricture
  • urinary retention
  • ventricular arrhythmias

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