Frovatriptan

Frovatriptan Brand Name– Frova

What is Frovatriptan

Frovatriptan is a central serotonin-receptor 1B and 1D agonist that is indicated for the treatment of acute migraine attacks with or without aura.

Frovatriptan is not indicated for the treatment of hemiplegic or basilar migraines or cluster headaches. The drug may be used off-label for menstrual migraine prophylaxis.

As with other second-generation 5-HT1 receptor agonists (“triptans”), frovatriptan is more lipophilic than sumatriptan.

Frovatriptan was also found to be a more potent contractile agent, compared to sumatriptan, on isolated basilar artery tissue.

Frovatriptan has a lower headache recurrence rate, compared to other agents in the triptan class, which may be explained by the long (26 hour) half-life, as well as the increased lipophilicity and potent contractile effects of this drug. Frovatriptan was approved by the FDA in November 2001.

Indications

  • menstrual migraine prophylaxis
  • migraine

For the treatment of acute migraine headache attacks with or without aura

Side Effects

  1. abdominal pain
  2. agitation
  3. amnesia
  4. anaphylactoid reactions
  5. angina
  6. angioedema
  7. anorexia
  8. arrhythmia exacerbation
  9. arthralgia
  10. asthenia
  11. ataxia
  12. back pain
  13. bowel ischemia
  14. bradycardia
  15. bullous rash
  16. cheilitis
  17. chest pain (unspecified)
  18. chest pressure syndrome
  19. colitis
  20. confusion
  21. conjunctivitis
  22. constipation
  23. coronary vasospasm
  24. dehydration
  25. dental pain
  26. depression
  27. diarrhea
  28. dizziness
  29. dysarthria
  30. dysesthesia
  31. dysgeusia
  32. dyspepsia
  33. dysphagia
  34. dyspnea
  35. edema
  36. emotional lability
  37. epistaxis
  38. eructation
  39. euphoria
  40. fatigue
  41. fever
  42. flatulence
  43. flushing
  44. gastroesophageal reflux
  45. headache
  46. hiccups
  47. hot flashes
  48. hyperacusis
  49. hyperesthesia
  50. hyperhidrosis
  51. hypersalivation
  52. hypertensive crisis
  53. hyperthermia
  54. hypertonia
  55. hyperventilation
  56. hypocalcemia
  57. hypoesthesia
  58. hypoglycemia
  59. hypotonia
  60. increased urinary frequency
  61. insomnia
  62. intracranial bleeding
  63. laryngitis
  64. malaise
  65. migraine
  66. muscle cramps
  67. musculoskeletal pain
  68. myalgia
  69. myasthenia
  70. myocardial infarction
  71. nausea
  72. nocturia
  73. ocular pain
  74. otalgia
  75. palpitations
  76. paresthesias
  77. peptic ulcer
  78. peripheral vasoconstriction
  79. pharyngitis
  80. polydipsia
  81. polyuria
  82. pruritus
  83. purpura
  84. rhinitis
  85. seizures
  86. serotonin syndrome
  87. sinus tachycardia
  88. sinusitis
  89. stomatitis
  90. stroke
  91. syncope
  92. tinnitus
  93. tremor
  94. ventricular fibrillation
  95. ventricular tachycardia
  96. vertigo
  97. visual impairment
  98. vomiting
  99. withdrawal
  100. xerostomia

Monitoring Parameters

  • ECG

Contraindications

  • acute myocardial infarction
  • angina
  • arteriosclerosis
  • basilar/hemiplegic migraine
  • breast-feeding
  • cardiac arrhythmias
  • cardiac disease
  • cerebrovascular disease
  • children
  • colitis
  • coronary artery disease
  • diabetes mellitus
  • driving or operating machinery
  • geriatric
  • hepatic disease
  • hypercholesterolemia
  • hypertension
  • infants
  • intracranial bleeding
  • myocardial infarction
  • neonates
  • obesity
  • peripheral vascular disease
  • pregnancy
  • Raynaud’s phenomenon
  • stroke
  • tobacco smoking
  • vasospastic angina
  • visual disturbance
  • Wolff-Parkinson-White syndrome

Interactions

  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Tramadol
  • Alfentanil
  • Almotriptan
  • Amitriptyline
  • Amitriptyline; Chlordiazepoxide
  • Amphetamine
  • Amphetamine; Dextroamphetamine
  • Amphetamine; Dextroamphetamine Salts
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Oxycodone
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Benzhydrocodone; Acetaminophen
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Benzphetamine
  • Bromocriptine
  • Brompheniramine; Dextromethorphan; Guaifenesin
  • Brompheniramine; Dextromethorphan; Phenylephrine
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Buprenorphine
  • Buprenorphine; Naloxone
  • Buspirone
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dextromethorphan
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Citalopram
  • Clomipramine
  • Cocaine
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • Desipramine
  • Desvenlafaxine
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dextroamphetamine
  • Dextromethorphan
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Guaifenesin
  • Dextromethorphan; Guaifenesin; Phenylephrine
  • Dextromethorphan; Guaifenesin; Potassium Guaiacolsulfonate
  • Dextromethorphan; Guaifenesin; Pseudoephedrine
  • Dextromethorphan; Promethazine
  • Dextromethorphan; Quinidine
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Doxepin
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Droxidopa
  • Duloxetine
  • Eletriptan
  • Ergot alkaloids
  • Escitalopram
  • Ethinyl Estradiol
  • Ethinyl Estradiol; Desogestrel
  • Ethinyl Estradiol; Ethynodiol Diacetate
  • Ethinyl Estradiol; Etonogestrel
  • Ethinyl Estradiol; Levonorgestrel
  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
  • Ethinyl Estradiol; Norgestrel
  • Fenfluramine
  • Fluoxetine
  • Fluoxetine; Olanzapine
  • Fluvoxamine
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Homatropine; Hydrocodone
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydromorphone
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Ibuprofen; Oxycodone
  • Imipramine
  • Isocarboxazid
  • Lasmiditan
  • Levomilnacipran
  • Levorphanol
  • Linezolid
  • Lisdexamfetamine
  • Lithium
  • Lorcaserin
  • Meperidine
  • Meperidine; Promethazine
  • Methadone
  • Methamphetamine
  • Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
  • Methylene Blue
  • Milnacipran
  • Mirtazapine
  • Morphine
  • Morphine; Naltrexone
  • Nalbuphine
  • Naproxen; Sumatriptan
  • Naratriptan
  • Nefazodone
  • Nortriptyline
  • Oxycodone
  • Oxymorphone
  • Ozanimod
  • Paroxetine
  • Perphenazine; Amitriptyline
  • Phenelzine
  • Protriptyline
  • Rasagiline
  • Remifentanil
  • Rizatriptan
  • Segesterone Acetate; Ethinyl Estradiol
  • Selective serotonin reuptake inhibitors
  • Selegiline
  • Sertraline
  • Sibutramine
  • St. John’s Wort, Hypericum perforatum
  • Sufentanil
  • Sumatriptan
  • Tapentadol
  • Tedizolid
  • Thiabendazole
  • Tramadol
  • Tranylcypromine
  • Trazodone
  • Tricyclic antidepressants
  • Trimipramine
  • Venlafaxine
  • Vilazodone
  • Vortioxetine
  • Zolmitriptan
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