Fostamatinib

Fostamatinib Brand Name– TAVALISSE

What is Fostamatinib

Fostamatinib is an oral, spleen tyrosine kinase (SYK) inhibitor indicated for the treatment of thrombocytopenia in adults with chronic immune thrombocytopenia (ITP) who have had an insufficient response to a previous treatment. Routine monitoring of complete blood count, including neutrophils, liver function tests, and blood pressure is necessary for assessing ongoing fostamatinib safety and tolerability for an individual patient.

Management of some adverse reactions, including neutropenia, hepatotoxicity, hypertension, and diarrhea, may require fostamatinib dosage interruption, reduction, or discontinuation.

Indications

  • immune thrombocytopenic purpura (ITP)

For the treatment of thrombocytopenia in patients with chronic immune thrombocytopenic purpura (ITP) who have had an insufficient response to previous treatment

Side Effects

  1. abdominal pain
  2. chest pain (unspecified)
  3. diarrhea
  4. dizziness
  5. elevated hepatic enzymes
  6. fatigue
  7. hepatotoxicity
  8. hypertension
  9. infection
  10. maculopapular rash
  11. nausea
  12. neutropenia
  13. rash

Monitoring Parameters

  • CBC with differential
  • LFTs

Contraindications

  • breast-feeding
  • children
  • contraception requirements
  • hypertension
  • infants
  • infertility
  • pregnancy
  • pregnancy testing
  • reproductive risk

Interactions

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