Fosinopril

Fosinopril Brand Name– Monopril

What is Fosinopril

Fosinopril is an oral angiotensin-converting enzyme (ACE) inhibitor used in the treatment of hypertension.

Fosinopril is a prodrug that is hydrolyzed by esterases to the active metabolite fosinoprilat.

It is longer-acting than captopril or enalapril, which allows for once-daily administration. Its pharmacodynamic characteristics most closely resemble those of benazepril, quinapril, and ramipril, all of which are prodrugs.

Neither fosinopril nor fosinoprilat contains a sulfhydryl group, which has implications regarding the drug’s adverse reaction profile.

Fosinopril (Monopril®) was approved by the FDA in May 1991.

A generic version of fosinopril was approved by the FDA on November 25, 2003.

Indications

  1. heart failure
  2. hypertension
  3. proteinuria

Side Effects

  1. abdominal pain
  2. agranulocytosis
  3. anaphylactoid reactions
  4. anemia
  5. angina
  6. angioedema
  7. arthralgia
  8. azotemia
  9. bradycardia
  10. bronchospasm
  11. chest pain (unspecified)
  12. cholestasis
  13. confusion
  14. constipation
  15. cough
  16. depression
  17. diarrhea
  18. dizziness
  19. drowsiness
  20. dysgeusia
  21. dysphagia
  22. edema
  23. elevated hepatic enzymes
  24. eosinophilia
  25. epistaxis
  26. fever
  27. flatulence
  28. flushing
  29. gout
  30. hepatic failure
  31. hepatic necrosis
  32. hepatitis
  33. hepatomegaly
  34. hyperhidrosis
  35. hyperkalemia
  36. hypertension
  37. hypertensive crisis
  38. hyponatremia
  39. hypotension
  40. increased urinary frequency
  41. infection
  42. influenza
  43. jaundice
  44. laryngitis
  45. leukopenia
  46. libido decrease
  47. lymphadenopathy
  48. memory impairment
  49. muscle cramps
  50. musculoskeletal pain
  51. myalgia
  52. myocardial infarction
  53. nausea
  54. neutropenia
  55. ocular irritation
  56. oliguria
  57. orthostatic hypotension
  58. palpitations
  59. pancreatitis
  60. pancytopenia
  61. paresthesias
  62. peripheral edema
  63. pharyngitis
  64. photosensitivity
  65. pruritus
  66. pyrosis (heartburn)
  67. rash
  68. renal failure (unspecified)
  69. rhinitis
  70. sinus tachycardia
  71. sinusitis
  72. stroke
  73. syncope
  74. teratogenesis
  75. thrombocytopenia
  76. tinnitus
  77. tremor
  78. urticaria
  79. vertigo
  80. visual impairment
  81. vomiting
  82. weakness
  83. weight gain
  84. weight loss
  85. xerostomia

Monitoring Parameters

  • blood pressure
  • serum creatinine/BUN
  • serum potassium
  • serum sodium

Contraindications

  • ACE-inhibitor induced angioedema
  • angioedema
  • Angiotensin-converting enzyme inhibitors (ACE inhibitors) hypersensitivity
  • aortic stenosis
  • autoimmune disease
  • Black patients
  • bone marrow suppression
  • breast-feeding
  • cardiomyopathy
  • cerebrovascular disease
  • collagen-vascular disease
  • coronary artery disease
  • dialysis
  • geriatric
  • heart failure
  • hepatic disease
  • hereditary angioedema
  • history of angioedema
  • hymenoptera venom (insect sting) allergy desensitization
  • hyperkalemia
  • hyponatremia
  • hypotension
  • hypovolemia
  • immunosuppression
  • infants
  • jaundice
  • low-density lipoprotein apheresis
  • neonates
  • pregnancy
  • renal artery stenosis
  • renal disease
  • renal failure
  • renal impairment
  • scleroderma
  • surgery
  • systemic lupus erythematosus (SLE)

Interactions

  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Acetaminophen; Pseudoephedrine
  • Acrivastine; Pseudoephedrine
  • Aldesleukin, IL-2
  • Alemtuzumab
  • Aliskiren
  • Aliskiren; Amlodipine
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Aliskiren; Valsartan
  • Alogliptin; Metformin
  • Alpha-glucosidase Inhibitors
  • Alprostadil
  • Amifostine
  • Amiloride
  • Amiloride; Hydrochlorothiazide, HCTZ
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amlodipine; Olmesartan
  • Amlodipine; Telmisartan
  • Amlodipine; Valsartan
  • Amobarbital
  • Amphetamine; Dextroamphetamine Salts
  • Amyl Nitrite
  • Angiotensin II
  • Angiotensin II receptor antagonists
  • Antacids
  • Apomorphine
  • Apraclonidine
  • Aprotinin
  • Aripiprazole
  • Asenapine
  • Azathioprine
  • Azilsartan
  • Azilsartan; Chlorthalidone
  • Baclofen
  • Benzphetamine
  • Bosentan
  • Brexpiprazole
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Brompheniramine; Dextromethorphan; Phenylephrine
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Brompheniramine; Pseudoephedrine
  • Cabergoline
  • Calcium Carbonate
  • Calcium Carbonate; Magnesium Hydroxide
  • Calcium Carbonate; Risedronate
  • Calcium Carbonate; Simethicone
  • Calcium Phosphate, Supersaturated
  • Canagliflozin; Metformin
  • Candesartan
  • Candesartan; Hydrochlorothiazide, HCTZ
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbetapentane; Pseudoephedrine
  • Carbidopa; Levodopa
  • Carbidopa; Levodopa; Entacapone
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carbinoxamine; Phenylephrine
  • Carbinoxamine; Pseudoephedrine
  • Cariprazine
  • Carvedilol
  • Cetirizine; Pseudoephedrine
  • Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
  • Chlophedianol; Guaifenesin; Phenylephrine
  • Chloroprocaine
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpheniramine; Pseudoephedrine
  • Clozapine
  • Co-Enzyme Q10, Ubiquinone
  • Cocaine
  • Codeine; Phenylephrine; Promethazine
  • Conivaptan
  • Cyclophosphamide
  • Cyclosporine
  • Dapagliflozin; Metformin
  • Desloratadine; Pseudoephedrine
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dexmethylphenidate
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Guaifenesin; Phenylephrine
  • Dextromethorphan; Guaifenesin; Pseudoephedrine
  • Dextromethorphan; Quinidine
  • Diazoxide
  • Diethylpropion
  • Digoxin
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Phenylephrine
  • Drospirenone
  • Drospirenone; Estradiol
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Duloxetine
  • Empagliflozin; Linagliptin; Metformin
  • Empagliflozin; Metformin
  • Enflurane
  • Entecavir
  • Ephedrine
  • Eplerenone
  • Eprosartan
  • Eprosartan; Hydrochlorothiazide, HCTZ
  • Ertugliflozin; Metformin
  • Estradiol
  • Estradiol Cypionate; Medroxyprogesterone
  • Etomidate
  • Everolimus
  • Fexofenadine; Pseudoephedrine
  • Fish Oil, Omega-3 Fatty Acids (Dietary Supplements)
  • Fluorescein
  • Fluoxetine; Olanzapine
  • Fospropofol
  • General anesthetics
  • Glipizide; Metformin
  • Glyburide; Metformin
  • Gold
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Guaifenesin; Phenylephrine
  • Guaifenesin; Pseudoephedrine
  • Haloperidol
  • Halothane
  • Heparin
  • Hydralazine; Isosorbide Dinitrate, ISDN
  • Hydrochlorothiazide, HCTZ; Irbesartan
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrochlorothiazide, HCTZ; Olmesartan
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Hydrochlorothiazide, HCTZ; Telmisartan
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Ibritumomab Tiuxetan
  • Ibuprofen; Pseudoephedrine
  • Icatibant
  • Iloperidone
  • Iloprost
  • Incretin Mimetics
  • Indapamide
  • Insulins
  • Intravenous Lipid Emulsions
  • Iohexol
  • Iopamidol
  • Iopromide
  • Ioversol
  • Irbesartan
  • Iron Dextran
  • Isocarboxazid
  • Isoflurane
  • Isoproterenol
  • Isosorbide Dinitrate, ISDN
  • Isosorbide Mononitrate
  • Isosulfan Blue
  • Kanamycin
  • Ketamine
  • Lanthanum Carbonate
  • Levodopa
  • Linagliptin; Metformin
  • Lisdexamfetamine
  • Lithium
  • Loop diuretics
  • Loratadine; Pseudoephedrine
  • Losartan
  • Lovastatin; Niacin
  • Lurasidone
  • Magnesium Salts
  • Magnesium Sulfate; Potassium Sulfate; Sodium Sulfate
  • Meglitinides
  • Mestranol; Norethindrone
  • Metformin
  • Metformin; Pioglitazone
  • Metformin; Repaglinide
  • Metformin; Rosiglitazone
  • Metformin; Saxagliptin
  • Metformin; Sitagliptin
  • Methamphetamine
  • Methohexital
  • Methylphenidate
  • Milrinone
  • Naproxen; Pseudoephedrine
  • Nateglinide
  • Nebivolol; Valsartan
  • Nefazodone
  • Nesiritide, BNP
  • Niacin, Niacinamide
  • Niacin; Simvastatin
  • Nitrates
  • Nitroglycerin
  • Nitroprusside
  • Non-Ionic Contrast Media
  • Nonsteroidal antiinflammatory drugs
  • Olanzapine
  • Olmesartan
  • Oxymetazoline
  • Paliperidone
  • Pentoxifylline
  • Phenelzine
  • Phenylephrine
  • Phenylephrine; Promethazine
  • Polyethylene Glycol; Electrolytes
  • Polyethylene Glycol; Electrolytes; Ascorbic Acid
  • Potassium
  • Potassium Phosphate
  • Potassium Phosphate; Sodium Phosphate
  • Pramlintide
  • Prazosin
  • Pregabalin
  • Procainamide
  • Procaine
  • Propofol
  • Pseudoephedrine
  • Quinidine
  • Rasagiline
  • Repaglinide
  • Risperidone
  • Sacubitril; Valsartan
  • Salicylates
  • Selegiline
  • Sevoflurane
  • SGLT2 Inhibitors
  • Silodosin
  • Sirolimus
  • Sodium Phosphate Monobasic Monohydrate; Sodium Phosphate Dibasic Anhydrous
  • Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
  • Spironolactone
  • Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
  • Sulfonylureas
  • Tacrolimus
  • Telavancin
  • Telbivudine
  • Telmisartan
  • Temsirolimus
  • Tetrabenazine
  • Tetracaine
  • Thiazide diuretics
  • Thiazolidinediones
  • Thiopental
  • Thiothixene
  • Tizanidine
  • Tolvaptan
  • Tranylcypromine
  • Trazodone
  • Triamterene
  • Trimethoprim
  • Valsartan
  • Yohimbine
  • Ziprasidone