Fluticasone Umeclidinium Vilanterol Brand Name– TRELEGY ELLIPTA
What is Fluticasone Umeclidinium Vilanterol
Fluticasone umeclidinium vilanterol is a triple combination containing an inhaled corticosteroid (ICS), (fluticasone), a long-acting muscarinic antagonist (LAMA), (umeclidinium), and a long-acting beta-2 adrenergic agonist (LABA) (vilanterol).
The combined inhalation is given once daily and used for the maintenance treatment of airflow obstruction in adults with chronic obstructive pulmonary disease (COPD).
According to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines, this triple combination should be reserved for consideration at follow-up in patients who are who are taking a LABA/LAMA combination and who develop further exacerbation.
The step-up to triple combination therapy with an ICS, a LABA, and a LAMA improves lung function, symptoms and health status and reduces exacerbations compared to the combination of ICS/LABA, LABA/LAMA, or LAMA monotherapy.
The FDA approved fluticasone; umeclidinium; vilanterol combination inhalation in 2017.
Indications
- chronic bronchitis
- chronic obstructive pulmonary disease (COPD)
- emphysema
For the maintenance treatment of chronic obstructive pulmonary disease (COPD), including chronic bronchitis and/or emphysema
Side Effects
- abdominal pain
- anaphylactoid reactions
- angioedema
- anxiety
- arrhythmia exacerbation
- arthralgia
- asthenia
- asthma-related death
- atrial fibrillation
- back pain
- blurred vision
- bone fractures
- bronchospasm
- candidiasis
- cataracts
- chest pain (unspecified)
- Churg-Strauss syndrome
- conjunctivitis
- constipation
- cough
- dental pain
- diabetes mellitus
- diarrhea
- dysgeusia
- dyspepsia
- dysphonia
- eosinophilia
- fever
- gastroesophageal reflux
- headache
- hyperglycemia
- hypertension
- hypokalemia
- hypothalamic-pituitary-adrenal (HPA) suppression
- infection
- influenza
- muscle cramps
- myocardial infarction
- nausea
- ocular hypertension
- osteoporosis
- palpitations
- peripheral edema
- pharyngitis
- premature ventricular contractions (PVCs)
- pruritus
- QT prolongation
- rash
- rhinitis
- sinus tachycardia
- sinusitis
- ST-T wave changes
- tremor
- urinary retention
- urticaria
- vasculitis
- vertigo
- vomiting
- wheezing
- xerostomia
Monitoring Parameters
- blood glucose
- pulmonary function tests (PFTs)
- serum potassium
Contraindications
- acute bronchospasm
- alcoholism
- anticholinergic medications
- asthma
- asthma-related death
- bladder obstruction
- bradycardia
- breast-feeding
- cardiac arrhythmias
- cardiac disease
- cataracts
- children
- closed-angle glaucoma
- contact lenses
- coronary artery disease
- diabetes mellitus
- females
- geriatric
- heart failure
- hepatic disease
- hyperglycemia
- hypertension
- hyperthyroidism
- hypocalcemia
- hypokalemia
- hypomagnesemia
- hypothalamic-pituitary-adrenal (HPA) suppression
- immunosuppression
- increased intraocular pressure
- infants
- infection
- labor
- long QT syndrome
- malnutrition
- MAOI therapy
- milk protein hypersensitivity
- myocardial infarction
- neonates
- ocular exposure
- ophthalmic administration
- osteoporosis
- paradoxical bronchospasm
- pheochromocytoma
- pregnancy
- prostatic hypertrophy
- QT prolongation
- seizure disorder
- seizures
- surgery
- thyroid disease
- thyrotoxicosis
- tobacco smoking
- tuberculosis
- urinary retention
Interactions
- Abarelix
- Abatacept
- Acebutolol
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Pseudoephedrine
- Acetazolamide
- Acetohexamide
- Aclidinium
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- Acrivastine; Pseudoephedrine
- Adalimumab
- Albiglutide
- Aldesleukin, IL-2
- Alemtuzumab
- Alfuzosin
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Alogliptin; Metformin
- Alpha-glucosidase Inhibitors
- Altretamine
- Ambenonium Chloride
- Amifampridine
- Amiloride; Hydrochlorothiazide, HCTZ
- Aminolevulinic Acid
- Aminosalicylate sodium, Aminosalicylic acid
- Amiodarone
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amphetamine
- Amphetamine; Dextroamphetamine
- Amphotericin B
- Amphotericin B cholesteryl sulfate complex (ABCD)
- Amphotericin B lipid complex (ABLC)
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- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
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- Carbinoxamine; Pseudoephedrine
- Carmustine, BCNU
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- Chlorambucil
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- Chloroquine
- Chlorothiazide
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Chlorpromazine
- Chlorpropamide
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- Chlorthalidone; Clonidine
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- Cimetidine
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- Denosumab
- Desipramine
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- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmethylphenidate
- Dextran
- Dextroamphetamine
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Dextromethorphan; Promethazine
- Dextromethorphan; Quinidine
- Diethylpropion
- Digoxin
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Dipeptidyl Peptidase-4 Inhibitors
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Phenylephrine
- Disopyramide
- Dobutamine
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- Dolasetron
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- Donepezil
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- Dopamine
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- Droperidol
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- Empagliflozin
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
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- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Enalapril; Hydrochlorothiazide, HCTZ
- Encorafenib
- Enflurane
- Entrectinib
- Ephedrine
- Epinephrine
- Eprosartan; Hydrochlorothiazide, HCTZ
- Eribulin
- Ertugliflozin
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- Erythromycin
- Erythromycin; Sulfisoxazole
- Escitalopram
- Esmolol
- Estramustine
- Estrogens
- Ethacrynic Acid
- Exenatide
- Ezogabine
- Fexofenadine; Pseudoephedrine
- Fingolimod
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- Fluphenazine
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- Formoterol
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- Foscarnet
- Fosinopril; Hydrochlorothiazide, HCTZ
- Furosemide
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- Glimepiride; Rosiglitazone
- Glipizide
- Glipizide; Metformin
- Glyburide
- Glyburide; Metformin
- Glycerol Phenylbutyrate
- Glycopyrrolate; Formoterol
- Goserelin
- Granisetron
- grapefruit juice
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guaifenesin; Phenylephrine
- Guaifenesin; Pseudoephedrine
- Halofantrine
- Haloperidol
- Halothane
- Hemin
- Heparin
- Hetastarch
- Histrelin
- Hydantoins
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ; Irbesartan
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrochlorothiazide, HCTZ; Valsartan
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydroxychloroquine
- Hydroxyurea
- Hydroxyzine
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ibritumomab Tiuxetan
- Ibuprofen; Pseudoephedrine
- Ibutilide
- Idelalisib
- Iloperidone
- Imipramine
- Incretin Mimetics
- Indacaterol
- Indacaterol; Glycopyrrolate
- Indapamide
- Indinavir
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- Insulin Degludec; Liraglutide
- Insulin Glargine; Lixisenatide
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- Isavuconazonium
- Isocarboxazid
- Isoflurane
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Isoproterenol
- Isotretinoin
- Itraconazole
- Ivosidenib
- Ketoconazole
- L-Asparaginase Escherichia coli
- Labetalol
- Lapatinib
- Lefamulin
- Lenvatinib
- Letermovir
- Leuprolide
- Leuprolide; Norethindrone
- Levetiracetam
- Levobetaxolol
- Levobunolol
- Levofloxacin
- Levomethadyl
- Levothyroxine
- Levothyroxine; Liothyronine (Porcine)
- Levothyroxine; Liothyronine (Synthetic)
- Linagliptin; Metformin
- Linezolid
- Liothyronine
- Liraglutide
- Lisdexamfetamine
- Lithium
- Lixisenatide
- Lofexidine
- Lomefloxacin
- Lomustine, CCNU
- Loop diuretics
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Loratadine; Pseudoephedrine
- Lumacaftor; Ivacaftor
- Macimorelin
- Magnesium Salicylate
- Mannitol
- Maprotiline
- Mecasermin rinfabate
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- Mefloquine
- Meglitinides
- Melphalan
- Mepenzolate
- Meperidine; Promethazine
- Mephobarbital
- Mepivacaine; Levonordefrin
- Mesoridazine
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Methacholine
- Methadone
- Methamphetamine
- Methazolamide
- Methenamine; Sodium Acid Phosphate
- Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
- Methoxsalen
- Methyclothiazide
- Methylphenidate
- Metolazone
- Metoprolol
- Metronidazole
- Metyrapone
- Micafungin
- Midodrine
- Midostaurin
- Mifepristone
- Mirabegron
- Mirtazapine
- Mitotane
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- Mivacurium
- Monoamine oxidase inhibitors
- Moxifloxacin
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- Nadolol
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- Norfloxacin
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- Ondansetron
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