Fluoxetine Olanzapine

Fluoxetine Olanzapine Brand Name– Symbyax

What is Fluoxetine Olanzapine

Fluoxetine olanzapine is a combination of an atypical antipsychotic, olanzapine, with a selective serotonin reuptake inhibitor (SSRI), fluoxetine.

Clinically, atypical antipsychotics have been frequently used in combination with SSRIs for a variety of psychiatric disorders.

Olanzapine, when added to an SSRI, can be used adjunctively to help patients with treatment-resistant depression, which is defined as non-response to 2 separate trials of different antidepressants of adequate dose and duration in the current episode.

Olanzapine, as a single agent, is useful for patients with a diagnosis of bipolar I disorder with manic or mixed episodes.

The addition of fluoxetine helps to alleviate bipolar depression better than the use of olanzapine alone. This drug combination was the first FDA-approved combination medication for the treatment of depressive episodes associated with bipolar I disorder.

According to a pivotal study, the combination helped to treat the symptoms of bipolar depression effectively and at a significantly faster rate than placebo; improvement occurred and was maintained during the entire 8 weeks of the trial. Additionally, the treated patients had no statistically greater risk of treatment-emergent mania than those taking placebo (induction of mania is a potential outcome of treatment with antidepressants alone).

Careful titration of dosage is recommended in bipolar patients. The combination of olanzapine; fluoxetine is approved for use in adults treatment-resistant depression.

The product is also approved for depressive episodes associated with bipolar I disorder in adults and pediatric patients 10 years of age and older.

Product labels for all antidepressants contain a boxed warning related to an increased risk of suicidality in children, adolescents, and young adults during the initial stages of therapy with an antidepressant, whether treating depression or other psychiatric conditions.

As with all products containing atypical antipsychotics, there is also a boxed warning regarding increased mortality risk in elderly patients treated for dementia-related psychosis.

The initial FDA-approval of these products was granted in December 2003.

Indications

• bipolar depression
• depression

For acute and maintenance treatment of treatment-resistant depression

Side Effects

1. abdominal pain
2. agranulocytosis
3. akathisia
4. alopecia
5. amenorrhea
6. amnesia
7. anaphylactoid reactions
8. anemia
9. angioedema
10. anxiety
11. aplastic anemia
12. appetite stimulation
13. arthralgia
14. asthenia
15. ataxia
16. back pain
17. bleeding
18. blurred vision
19. bone fractures
20. bradycardia
21. breast enlargement
22. bronchospasm
23. chills
24. cholestasis
25. coma
26. constipation
27. depression
28. diabetes mellitus
29. diarrhea
30. drowsiness
31. Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
32. dysarthria
33. dysgeusia
34. dysmenorrhea
35. dyspepsia
36. dysphagia
37. dysphemia
38. dystonic reaction
39. dysuria
40. ecchymosis
41. edema
42. ejaculation dysfunction
43. elevated hepatic enzymes
44. emotional lability
45. eosinophilic pneumonia
46. epistaxis
47. erythema multiforme
48. esophageal ulceration
49. euphoria
50. exfoliative dermatitis
51. fatigue
52. fever
53. flatulence
54. galactorrhea
55. gastritis
56. GI bleeding
57. GI obstruction
58. gout
59. gynecomastia
60. headache
61. hepatitis
62. hyperbilirubinemia
63. hypercholesterolemia
64. hyperglycemia
65. hyperhidrosis
66. hyperkinesis
67. hyperlipidemia
68. hyperprolactinemia
69. hypersalivation
70. hypertriglyceridemia
71. hyponatremia
72. hypotension
73. ileus
74. impotence (erectile dysfunction)
75. increased urinary frequency
76. insomnia
77. jaundice
78. laryngospasm
79. leukopenia
80. libido decrease
81. libido increase
82. maculopapular rash
83. mania
84. mastalgia
85. menorrhagia
86. menstrual irregularity
87. musculoskeletal pain
88. myoclonia
89. nausea
90. neonatal abstinence syndrome
91. neuroleptic malignant syndrome
92. neutropenia
93. orgasm dysfunction
94. orthostatic hypotension
95. osteopenia
96. osteoporosis
97. pancreatitis
98. peptic ulcer
99. peripheral vasodilation
100. persistent pulmonary hypertension of the newborn
101. photosensitivity
102. platelet dysfunction
103. polydipsia
104. priapism
105. pruritus
106. pseudoparkinsonism
107. pulmonary embolism
108. purpura
109. QT prolongation
110. rash
111. restless legs syndrome (RLS)
112. restlessness
113. rhabdomyolysis
114. serotonin syndrome
115. serum sickness
116. SIADH
117. sinus tachycardia
118. sinusitis
119. Stevens-Johnson syndrome
120. stroke
121. suicidal ideation
122. syncope
123. tardive dyskinesia
124. teeth grinding (bruxism)
125. thrombocytopenia
126. thrombosis
127. toxic epidermal necrolysis
128. tremor
129. urinary incontinence
130. urinary retention
131. urinary urgency
132. urticaria
133. vasculitis
134. vomiting
135. water intoxication
136. weight gain
137. weight loss
138. withdrawal
139. xerophthalmia
140. xerosis
141. xerostomia
142. yawning

Monitoring Parameters

• AIMS assessment
• blood glucose
• CBC
• glycosylated hemoglobin A1c (HbA1c)
• LFTs
• neurologic function
• pregnancy testing
• serum creatinine
• serum electrolytes
• serum lipid profile
• serum prolactin
• thyroid function tests (TFTs)
• weight

Contraindications

• abrupt discontinuation
• agranulocytosis
• ambient temperature increase
• anorexia nervosa
• anticholinergic medications
• anticoagulant therapy
• bleeding
• bone fractures
• bradycardia
• breast cancer
• breast-feeding
• cardiac arrhythmias
• cardiac disease
• cerebrovascular disease
• children
• closed-angle glaucoma
• CNS depression
• coma
• constipation
• dehydration
• dementia
• diabetes mellitus
• driving or operating machinery
• dysphagia
• electroconvulsive therapy (ECT)
• electrolyte imbalance
• ethanol ingestion
• fever
• geriatric
• GI obstruction
• heart failure
• hematological disease
• hepatic disease
• hepatitis
• hyperprolactinemia
• hyperthermia
• hypokalemia
• hypomagnesemia
• hyponatremia
• hypothermia
• hypovolemia
• ileus
• increased intraocular pressure
• infertility
• jaundice
• leukopenia
• mania
• MAOI therapy
• myocardial infarction
• neonates
• neurological disease
• neutropenia
• obesity
• orthostatic hypotension
• osteoporosis
• Parkinson’s disease
• poor metabolizers
• pregnancy
• pregnancy testing
• prostatic hypertrophy
• QT prolongation
• renal disease
• renal failure
• renal impairment
• seizure disorder
• seizures
• strenuous exercise
• stroke
• suicidal ideation
• surgery
• syncope
• tachycardia
• tardive dyskinesia
• thrombolytic therapy
• tobacco smoking
• urinary retention
• ventricular arrhythmias

Interactions

• Abarelix
• Abciximab
• Abemaciclib
• Acarbose
• Acebutolol
• Acetaminophen; Aspirin, ASA; Caffeine
• Acetaminophen; Butalbital
• Acetaminophen; Butalbital; Caffeine
• Acetaminophen; Butalbital; Caffeine; Codeine
• Acetaminophen; Caffeine; Dihydrocodeine
• Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
• Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
• Acetaminophen; Codeine
• Acetaminophen; Dextromethorphan
• Acetaminophen; Dextromethorphan; Doxylamine
• Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
• Acetaminophen; Dextromethorphan; Phenylephrine
• Acetaminophen; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Dichloralphenazone; Isometheptene
• Acetaminophen; Diphenhydramine
• Acetaminophen; Hydrocodone
• Acetaminophen; Oxycodone
• Acetaminophen; Pentazocine
• Acetaminophen; Propoxyphene
• Acetaminophen; Tramadol
• Aclidinium; Formoterol
• Albendazole
• Albiglutide
• Albuterol
• Albuterol; Ipratropium
• Aldesleukin, IL-2
• Alfentanil
• Alfuzosin
• Aliskiren; Amlodipine
• Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
• Aliskiren; Hydrochlorothiazide, HCTZ
• Aliskiren; Valsartan
• Almotriptan
• Alogliptin
• Alogliptin; Metformin
• Alogliptin; Pioglitazone
• Alosetron
• Alpha-glucosidase Inhibitors
• Alprazolam
• Alteplase
• Amantadine
• Ambenonium Chloride
• Amifampridine
• Amiloride
• Amiloride; Hydrochlorothiazide, HCTZ
• Amiodarone
• Amitriptyline
• Amitriptyline; Chlordiazepoxide
• Amlodipine
• Amlodipine; Atorvastatin
• Amlodipine; Benazepril
• Amlodipine; Celecoxib
• Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
• Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
• Amlodipine; Olmesartan
• Amlodipine; Telmisartan
• Amlodipine; Valsartan
• Amobarbital
• Amoxapine
• Amoxicillin; Clarithromycin; Lansoprazole
• Amoxicillin; Clarithromycin; Omeprazole
• Amphetamines
• Anagrelide
• Angiotensin II receptor antagonists
• Angiotensin-converting enzyme inhibitors
• Anticholinergics
• Antithrombin III
• Apixaban
• Apomorphine
• Aprepitant, Fosaprepitant
• Ardeparin
• Arformoterol
• Aripiprazole
• Armodafinil
• Arsenic Trioxide
• Artemether; Lumefantrine
• Articaine; Epinephrine
• Asenapine
• Aspirin, ASA
• Aspirin, ASA; Butalbital; Caffeine
• Aspirin, ASA; Butalbital; Caffeine; Codeine
• Aspirin, ASA; Caffeine; Dihydrocodeine
• Aspirin, ASA; Caffeine; Orphenadrine
• Aspirin, ASA; Carisoprodol
• Aspirin, ASA; Carisoprodol; Codeine
• Aspirin, ASA; Citric Acid; Sodium Bicarbonate
• Aspirin, ASA; Dipyridamole
• Aspirin, ASA; Omeprazole
• Aspirin, ASA; Oxycodone
• Aspirin, ASA; Pravastatin
• Atazanavir
• Atazanavir; Cobicistat
• Atenolol
• Atenolol; Chlorthalidone
• Atomoxetine
• Atropine
• Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
• Atropine; Difenoxin
• Atropine; Diphenoxylate
• Atropine; Edrophonium
• Atropine; Hyoscyamine; Phenobarbital; Scopolamine
• Azilsartan
• Azilsartan; Chlorthalidone
• Azithromycin
• Barbiturates
• Bedaquiline
• Belladonna Alkaloids; Ergotamine; Phenobarbital
• Belladonna; Opium
• Benazepril
• Benazepril; Hydrochlorothiazide, HCTZ
• Bendroflumethiazide; Nadolol
• Benzhydrocodone; Acetaminophen
• Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
• Benztropine
• Bepridil
• Beta-adrenergic blockers
• Betaxolol
• Bethanechol
• Betrixaban
• Bicalutamide
• Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
• Bismuth Subsalicylate
• Bismuth Subsalicylate; Metronidazole; Tetracycline
• Bisoprolol
• Bisoprolol; Hydrochlorothiazide, HCTZ
• Boceprevir
• Bortezomib
• Bosentan
• Brexpiprazole
• Brimonidine; Timolol
• Bromocriptine
• Brompheniramine
• Brompheniramine; Carbetapentane; Phenylephrine
• Brompheniramine; Dextromethorphan; Guaifenesin
• Brompheniramine; Dextromethorphan; Phenylephrine
• Brompheniramine; Guaifenesin; Hydrocodone
• Brompheniramine; Hydrocodone; Pseudoephedrine
• Brompheniramine; Pseudoephedrine
• Budesonide
• Budesonide; Formoterol
• Bumetanide
• Bupivacaine
• Bupivacaine Liposomal
• Bupivacaine; Lidocaine
• Buprenorphine
• Buprenorphine; Naloxone
• Bupropion
• Bupropion; Naltrexone
• Buspirone
• Butabarbital
• Butorphanol
• Cabergoline
• Caffeine; Ergotamine
• Calcium-channel blockers
• Canagliflozin
• Canagliflozin; Metformin
• Candesartan
• Candesartan; Hydrochlorothiazide, HCTZ
• Cangrelor
• Cannabidiol
• Captopril
• Captopril; Hydrochlorothiazide, HCTZ
• Carbamazepine
• Carbetapentane; Chlorpheniramine
• Carbetapentane; Chlorpheniramine; Phenylephrine
• Carbetapentane; Diphenhydramine; Phenylephrine
• Carbetapentane; Guaifenesin
• Carbetapentane; Guaifenesin; Phenylephrine
• Carbetapentane; Phenylephrine
• Carbetapentane; Phenylephrine; Pyrilamine
• Carbetapentane; Pseudoephedrine
• Carbetapentane; Pyrilamine
• Carbidopa; Levodopa
• Carbidopa; Levodopa; Entacapone
• Carbinoxamine
• Carbinoxamine; Dextromethorphan; Pseudoephedrine
• Carbinoxamine; Hydrocodone; Phenylephrine
• Carbinoxamine; Hydrocodone; Pseudoephedrine
• Carbinoxamine; Phenylephrine
• Carbinoxamine; Pseudoephedrine
• Cariprazine
• Carisoprodol
• Carteolol
• Carvedilol
• Cenobamate
• Central-acting adrenergic agents
• Ceritinib
• Cetirizine
• Cetirizine; Pseudoephedrine
• Cetrorelix
• Cevimeline
• Charcoal
• Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
• Chlorcyclizine
• Chlordiazepoxide
• Chlordiazepoxide; Clidinium
• Chloroquine
• Chlorothiazide
• Chlorpheniramine
• Chlorpheniramine; Codeine
• Chlorpheniramine; Dextromethorphan
• Chlorpheniramine; Dextromethorphan; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
• Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Hydrocodone
• Chlorpheniramine; Hydrocodone; Phenylephrine
• Chlorpheniramine; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Phenylephrine
• Chlorpheniramine; Pseudoephedrine
• Chlorpromazine
• Chlorthalidone
• Chlorthalidone; Clonidine
• Chlorzoxazone
• Choline Salicylate; Magnesium Salicylate
• Cilostazol
• Cimetidine
• Cinacalcet
• Ciprofloxacin
• Cisapride
• Citalopram
• Clarithromycin
• Clemastine
• Clobazam
• Clofazimine
• Clomipramine
• Clonazepam
• Clopidogrel
• Clorazepate
• Clozapine
• Cobicistat
• Cobimetinib
• Cocaine
• Codeine
• Codeine; Guaifenesin
• Codeine; Phenylephrine; Promethazine
• Codeine; Promethazine
• COMT inhibitors
• Conjugated Estrogens
• Conjugated Estrogens; Bazedoxifene
• Conjugated Estrogens; Medroxyprogesterone
• Crizotinib
• Cyclobenzaprine
• Cyclosporine
• Cyproheptadine
• Dabigatran
• Dalteparin
• Danaparoid
• Dantrolene
• Dapagliflozin
• Dapagliflozin; Metformin
• Dapagliflozin; Saxagliptin
• Darifenacin
• Darunavir; Cobicistat
• Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
• Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
• Dasatinib
• Degarelix
• Delavirdine
• Desflurane
• Desipramine
• Desmopressin
• Desvenlafaxine
• Deutetrabenazine
• Dexchlorpheniramine
• Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
• Dexmethylphenidate
• Dextromethorphan
• Dextromethorphan; Diphenhydramine; Phenylephrine
• Dextromethorphan; Guaifenesin
• Dextromethorphan; Guaifenesin; Phenylephrine
• Dextromethorphan; Guaifenesin; Potassium Guaiacolsulfonate
• Dextromethorphan; Guaifenesin; Pseudoephedrine
• Dextromethorphan; Promethazine
• Dextromethorphan; Quinidine
• Diazepam
• Dicyclomine
• Dienogest; Estradiol valerate
• Diethylpropion
• Dihydrocodeine; Guaifenesin; Pseudoephedrine
• Dihydroergotamine
• Diltiazem
• Dimenhydrinate
• Dipeptidyl Peptidase-4 Inhibitors
• Diphenhydramine
• Diphenhydramine; Hydrocodone; Phenylephrine
• Diphenhydramine; Ibuprofen
• Diphenhydramine; Naproxen
• Diphenhydramine; Phenylephrine
• Dipyridamole
• Disopyramide
• Diuretics
• Docetaxel
• Dofetilide
• Dolasetron
• Dolutegravir; Rilpivirine
• Donepezil
• Donepezil; Memantine
• Dorzolamide; Timolol
• Doxazosin
• Doxepin
• Doxercalciferol
• Doxylamine
• Doxylamine; Pyridoxine
• Dronabinol
• Dronedarone
• Droperidol
• Drospirenone; Estradiol
• Drospirenone; Ethinyl Estradiol; Levomefolate
• Dulaglutide
• Duloxetine
• Dutasteride; Tamsulosin
• Edoxaban
• Efavirenz
• Efavirenz; Emtricitabine; Tenofovir
• Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
• Elagolix; Estradiol; Norethindrone acetate
• Elbasvir; Grazoprevir
• Eletriptan
• Elexacaftor; tezacaftor; ivacaftor
• Eliglustat
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
• Empagliflozin
• Empagliflozin; Linagliptin
• Empagliflozin; Linagliptin; Metformin
• Empagliflozin; Metformin
• Emtricitabine; Rilpivirine; Tenofovir alafenamide
• Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
• Enalapril, Enalaprilat
• Enalapril; Felodipine
• Enalapril; Hydrochlorothiazide, HCTZ
• Encainide
• Encorafenib
• Enflurane
• Enoxaparin
• Entacapone
• Entrectinib
• Epinephrine
• Eplerenone
• Epoprostenol
• Eprosartan
• Eprosartan; Hydrochlorothiazide, HCTZ
• Eptifibatide
• Ergoloid Mesylates
• Ergonovine
• Ergot alkaloids
• Ergotamine
• Eribulin
• Ertugliflozin
• Ertugliflozin; Metformin
• Ertugliflozin; Sitagliptin
• Erythromycin
• Erythromycin; Sulfisoxazole
• Escitalopram
• Esketamine
• Esmolol
• Esomeprazole
• Esomeprazole; Naproxen
• Estazolam
• Esterified Estrogens
• Esterified Estrogens; Methyltestosterone
• Estradiol
• Estradiol Cypionate; Medroxyprogesterone
• Estradiol; Levonorgestrel
• Estradiol; Norethindrone
• Estradiol; Norgestimate
• Estradiol; Progesterone
• Estropipate
• Eszopiclone
• Ethacrynic Acid
• Ethanol
• Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
• Ethotoin
• Everolimus
• Exenatide
• Ezogabine
• Fedratinib
• Felodipine
• Fenfluramine
• Fenofibric Acid
• Fentanyl
• Fesoterodine
• Fingolimod
• Flavoxate
• Flecainide
• Flibanserin
• Fluconazole
• Fluphenazine
• Flurazepam
• Fluticasone; Salmeterol
• Fluticasone; Umeclidinium; Vilanterol
• Fluticasone; Vilanterol
• Fluvastatin
• Fluvoxamine
• Fondaparinux
• food
• Formoterol
• Formoterol; Mometasone
• Foscarnet
• Fosinopril
• Fosinopril; Hydrochlorothiazide, HCTZ
• Fosphenytoin
• Frovatriptan
• Furosemide
• Gabapentin
• Galantamine
• Ganirelix
• Gefitinib
• Gemifloxacin
• Gemtuzumab Ozogamicin
• Gilteritinib
• Glasdegib
• Glimepiride; Pioglitazone
• Glimepiride; Rosiglitazone
• Glipizide; Metformin
• Glyburide; Metformin
• Glycopyrrolate
• Glycopyrrolate; Formoterol
• Goserelin
• Granisetron
• Guaifenesin; Hydrocodone
• Guaifenesin; Hydrocodone; Pseudoephedrine
• Halofantrine
• Halogenated Anesthetics
• Haloperidol
• Halothane
• Heparin
• Histrelin
• Homatropine; Hydrocodone
• Hydantoins
• Hydralazine; Hydrochlorothiazide, HCTZ
• Hydrochlorothiazide, HCTZ
• Hydrochlorothiazide, HCTZ; Irbesartan
• Hydrochlorothiazide, HCTZ; Lisinopril
• Hydrochlorothiazide, HCTZ; Losartan
• Hydrochlorothiazide, HCTZ; Methyldopa
• Hydrochlorothiazide, HCTZ; Metoprolol
• Hydrochlorothiazide, HCTZ; Moexipril
• Hydrochlorothiazide, HCTZ; Olmesartan
• Hydrochlorothiazide, HCTZ; Propranolol
• Hydrochlorothiazide, HCTZ; Quinapril
• Hydrochlorothiazide, HCTZ; Spironolactone
• Hydrochlorothiazide, HCTZ; Telmisartan
• Hydrochlorothiazide, HCTZ; Triamterene
• Hydrochlorothiazide, HCTZ; Valsartan
• Hydrocodone
• Hydrocodone; Ibuprofen
• Hydrocodone; Phenylephrine
• Hydrocodone; Potassium Guaiacolsulfonate
• Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
• Hydrocodone; Pseudoephedrine
• Hydromorphone
• Hydroxychloroquine
• Hydroxyzine
• Hyoscyamine
• Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
• Ibuprofen; Oxycodone
• Ibutilide
• Ifosfamide
• Iloperidone
• Iloprost
• Imatinib
• Imipramine
• Incretin Mimetics
• Indacaterol
• Indacaterol; Glycopyrrolate
• Indapamide
• Inotuzumab Ozogamicin
• Insulin Degludec; Liraglutide
• Insulin Glargine; Lixisenatide
• Insulins
• Irbesartan
• Isavuconazonium
• Isocarboxazid
• Isoflurane
• Isoniazid, INH
• Isoniazid, INH; Pyrazinamide, PZA; Rifampin
• Isoniazid, INH; Rifampin
• Isradipine
• Itraconazole
• Ivabradine
• Ivacaftor
• Ivosidenib
• Ixabepilone
• Ketoconazole
• Labetalol
• Lapatinib
• Lasmiditan
• Lefamulin
• Lemborexant
• Lenvatinib
• Lesinurad
• Lesinurad; Allopurinol
• Leuprolide
• Leuprolide; Norethindrone
• Levalbuterol
• Levobetaxolol
• Levobunolol
• Levocetirizine
• Levodopa
• Levofloxacin
• Levomefolate
• Levomethadyl
• Levomilnacipran
• Levorphanol
• Lidocaine
• Lidocaine; Prilocaine
• Linagliptin
• Linagliptin; Metformin
• Linezolid
• Liraglutide
• Lisinopril
• Lithium
• Lixisenatide
• Lofexidine
• Lomitapide
• Long-acting beta-agonists
• Loop diuretics
• Loperamide
• Loperamide; Simethicone
• Lopinavir; Ritonavir
• Lorazepam
• Lorcaserin
• Losartan
• Low Molecular Weight Heparins
• Loxapine
• Lumacaftor; Ivacaftor
• Lumacaftor; Ivacaftor
• Lumateperone
• Lurasidone
• Macimorelin
• Magnesium Salicylate
• Maprotiline
• Maraviroc
• Mecamylamine
• Meclizine
• Mefloquine
• Meglitinides
• Melatonin
• Mepenzolate
• Meperidine
• Meperidine; Promethazine
• Mephobarbital
• Meprobamate
• Mesoridazine
• Metaproterenol
• Metformin
• Metformin; Pioglitazone
• Metformin; Repaglinide
• Metformin; Rosiglitazone
• Metformin; Saxagliptin
• Metformin; Sitagliptin
• Methadone
• Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
• Methohexital
• Methscopolamine
• Methyclothiazide
• Methylene Blue
• Methylergonovine
• Methylphenidate
• Methysergide
• Metoclopramide
• Metolazone
• Metoprolol
• Metronidazole
• Mexiletine
• Midazolam
• Midostaurin
• Mifepristone
• Miglitol
• Milnacipran
• Mirabegron
• Mirtazapine
• Modafinil
• Moexipril
• Molindone
• Monoamine oxidase inhibitors
• Morphine
• Morphine; Naltrexone
• Moxifloxacin
• Nabilone
• Nadolol
• Nafarelin
• Nalbuphine
• Nanoparticle Albumin-Bound Paclitaxel
• Naproxen; Sumatriptan
• Naratriptan
• Nateglinide
• Nebivolol
• Nebivolol; Valsartan
• Nefazodone
• Netupitant, Fosnetupitant; Palonosetron
• Nicardipine
• Nifedipine
• Nilotinib
• Nimodipine
• Nisoldipine
• Nitroglycerin
• Non-Ionic Contrast Media
• Nonsteroidal antiinflammatory drugs
• Norfloxacin
• Nortriptyline
• Obeticholic Acid
• Octreotide
• Ofloxacin
• Olanzapine
• Olmesartan
• Olodaterol
• Ombitasvir; Paritaprevir; Ritonavir
• Ondansetron
• Oritavancin
• Orphenadrine
• Osilodrostat
• Osimertinib
• Oxaliplatin
• Oxazepam
• Oxybutynin
• Oxycodone
• Oxymorphone
• Ozanimod
• Paclitaxel
• Paliperidone
• Palonosetron
• Panobinostat
• Paricalcitol
• Paroxetine
• Pasireotide
• Pazopanib
• Peginterferon Alfa-2b
• Penbutolol
• Pentamidine
• Pentazocine
• Pentazocine; Naloxone
• Pentobarbital
• Pentosan
• Perampanel
• Pergolide
• Perindopril
• Perindopril; Amlodipine
• Perphenazine
• Perphenazine; Amitriptyline
• Phenelzine
• Phenobarbital
• Phenoxybenzamine
• Phentermine
• Phentermine; Topiramate
• Phenylephrine; Promethazine
• Phenytoin
• Pimavanserin
• Pimozide
• Pindolol
• Pioglitazone
• Pirbuterol
• Pitolisant
• Posaconazole
• Potassium-sparing diuretics
• Pramipexole
• Pramlintide
• Prasugrel
• Pregabalin
• Prilocaine; Epinephrine
• Primaquine
• Primidone
• Procainamide
• Procarbazine
• Prochlorperazine
• Promethazine
• Propafenone
• Propantheline
• Propoxyphene
• Propranolol
• Protriptyline
• Quazepam
• Quetiapine
• Quinapril
• Quinidine
• Quinine
• Ramelteon
• Ramipril
• Ranolazine
• Rasagiline
• Remifentanil
• Repaglinide
• Reserpine
• Reteplase, r-PA
• Ribociclib
• Ribociclib; Letrozole
• Rifampin
• Rilpivirine
• Risperidone
• Ritonavir
• Rivaroxaban
• Rivastigmine
• Rizatriptan
• Rolapitant
• Romidepsin
• Ropinirole
• Rosiglitazone
• Rotigotine
• Ruxolitinib
• Sacubitril; Valsartan
• Safinamide
• Salmeterol
• Salsalate
• Saquinavir
• Saxagliptin
• Scopolamine
• Secobarbital
• Selegiline
• Selpercatinib
• Semaglutide
• Sertraline
• Sevoflurane
• SGLT2 Inhibitors
• Short-acting beta-agonists
• Sibutramine
• Sildenafil
• Simeprevir
• Simvastatin; Sitagliptin
• Siponimod
• Sirolimus
• Sitagliptin
• Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
• Sofosbuvir; Velpatasvir
• Sofosbuvir; Velpatasvir; Voxilaprevir
• Solifenacin
• Sorafenib
• Sotalol
• Sparfloxacin
• Spironolactone
• St. John’s Wort, Hypericum perforatum
• Streptokinase
• Sufentanil
• Sulfonylureas
• Sumatriptan
• Sunitinib
• Suvorexant
• Tacrine
• Tacrolimus
• Tadalafil
• Tamoxifen
• Tamsulosin
• Tapentadol
• Tedizolid
• Telaprevir
• Telavancin
• Telithromycin
• Telmisartan
• Temazepam
• Tenecteplase
• Terazosin
• Terbinafine
• Terbutaline
• Tetrabenazine
• Tezacaftor; Ivacaftor
• Thiabendazole
• Thiazide diuretics
• Thiazolidinediones
• Thiethylperazine
• Thiopental
• Thioridazine
• Thiothixene
• Thrombin Inhibitors
• Thrombolytic Agents
• Ticagrelor
• Ticlopidine
• Timolol
• Tinzaparin
• Tiotropium; Olodaterol
• Tipranavir
• Tirofiban
• tobacco
• Tofacitinib
• Tolcapone
• Tolterodine
• Tolvaptan
• Topiramate
• Toremifene
• Torsemide
• Tramadol
• Trandolapril
• Trandolapril; Verapamil
• Tranylcypromine
• Trazodone
• Treprostinil
• Triamterene
• Triazolam
• Triclabendazole
• Tricyclic antidepressants
• Trifluoperazine
• Trihexyphenidyl
• Trimipramine
• Triprolidine
• Triptorelin
• Trospium
• Ubrogepant
• Ulipristal
• Umeclidinium; Vilanterol
• Urokinase
• Valbenazine
• Valerian, Valeriana officinalis
• Valsartan
• Vandetanib
• Vardenafil
• Vasodilators
• Vasopressin, ADH
• Vemurafenib
• Venetoclax
• Venlafaxine
• Verapamil
• Vilazodone
• Vinblastine
• Vinorelbine
• Vorapaxar
• Voriconazole
• Vorinostat
• Vortioxetine
• Warfarin
• Zaleplon
• Ziconotide
• Ziprasidone
• Zolmitriptan
• Zolpidem
• Zonisamide