Fluoxymesterone

Fluoxymesterone Brand Name– ANDROXY | Halotestin

What is Fluoxymesterone

Fluoxymesterone a 17-alpha alkylated derivative of testosterone, is an oral androgen. Therapeutically, it is used for primary or hypogonadotropic hypogonadism and delayed puberty in males. Historically the drug has also been inoperable breast cancer in females.

Androgens are responsible for the normal growth and development of male sex organs and secondary characteristics.

Fluoxymesterone also inhibits the formation of estrogen, which may be the mechanism of action for breast cancer. Anabolic steroid derivatives of testosterone, such as fluoxymesterone, have been used illicitly.

Fluoxymesterone was approved by the FDA in 1956.

Indications

  1. breast cancer
  2. delayed puberty
  3. hypogonadism

NOTE: This drug has not been shown to be safe and effective for the enhancement of athletic performance. Due to the potential risk of serious adverse health effects, this drug should not be used for such purpose.

For androgen replacement therapy in male hypogonadism

Side Effects

  1. acne vulgaris
  2. alopecia
  3. amenorrhea
  4. anaphylactoid reactions
  5. anxiety
  6. bleeding
  7. clitoromegaly
  8. depression
  9. edema
  10. epiphyseal closure
  11. feminization
  12. gynecomastia
  13. headache
  14. heart failure
  15. hepatitis
  16. hirsutism
  17. hypercalcemia
  18. hypercholesterolemia
  19. jaundice
  20. libido decrease
  21. libido increase
  22. nausea
  23. oligomenorrhea
  24. oligospermia
  25. paresthesias
  26. peliosis hepatis
  27. polycythemia
  28. prostatic hypertrophy
  29. virilization

Monitoring Parameters

  • LFTs

Contraindications

  • breast cancer
  • breast-feeding
  • cardiac disease
  • children
  • diabetes mellitus
  • geriatric
  • hepatic disease
  • hypercalcemia
  • hypothyroidism
  • pregnancy
  • prostate cancer
  • renal disease

Interactions

  • Abarelix
  • Acarbose
  • Alogliptin
  • Alogliptin; Metformin
  • Alogliptin; Pioglitazone
  • Alpha-glucosidase Inhibitors
  • Azelastine; Fluticasone
  • Beclomethasone
  • Betamethasone
  • Budesonide
  • Budesonide; Formoterol
  • Canagliflozin
  • Canagliflozin; Metformin
  • Ciclesonide
  • Corticosteroids
  • Cortisone
  • Cyclosporine
  • Dapagliflozin
  • Dapagliflozin; Metformin
  • Dapagliflozin; Saxagliptin
  • Darbepoetin Alfa
  • Deflazacort
  • Degarelix
  • Dexamethasone
  • Dipeptidyl Peptidase-4 Inhibitors
  • Empagliflozin
  • Empagliflozin; Linagliptin
  • Empagliflozin; Linagliptin; Metformin
  • Empagliflozin; Metformin
  • Epoetin Alfa
  • Ertugliflozin
  • Ertugliflozin; Metformin
  • Ertugliflozin; Sitagliptin
  • Fludrocortisone
  • Flunisolide
  • Fluticasone
  • Fluticasone; Salmeterol
  • Fluticasone; Umeclidinium; Vilanterol
  • Fluticasone; Vilanterol
  • Formoterol; Mometasone
  • Glipizide; Metformin
  • Glyburide; Metformin
  • Goserelin
  • Histrelin
  • Hydrocortisone
  • Incretin Mimetics
  • Insulins
  • Leuprolide
  • Leuprolide; Norethindrone
  • Linagliptin
  • Linagliptin; Metformin
  • Meglitinides
  • Metformin
  • Metformin; Pioglitazone
  • Metformin; Repaglinide
  • Metformin; Rosiglitazone
  • Metformin; Saxagliptin
  • Metformin; Sitagliptin
  • Methoxy polyethylene glycol-epoetin beta
  • Methylprednisolone
  • Miglitol
  • Mometasone
  • Nafarelin
  • Pramlintide
  • Prednisolone
  • Prednisone
  • Saw Palmetto, Serenoa repens
  • Saxagliptin
  • SGLT2 Inhibitors
  • Simvastatin; Sitagliptin
  • Sitagliptin
  • Sulfonylureas
  • Thiazolidinediones
  • Thyroid hormones
  • Triamcinolone
  • Triptorelin
  • Warfarin
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