Fluocinolone Hydroquinone Tretinoin Brand Name– Tri Luma
What is Fluocinolone Hydroquinone Tretinoin
Fluocinolone hydroquinone tretinoin (all-trans retinoic acid) are used together in a topical preparation to lighten the appearance of melasma.
Melasma is a condition characterized by a darkening of the skin on the face caused by a change in hormones, such as pregnancy or beginning oral contraceptive or hormone replacement therapy.
Two studies of the efficacy and safety of fluocinolone-hydroquinone-tretinoin for the treatment of melasma demonstrated that the combination of the three drugs was superior to any combination containing two of the three active ingredients.
With proper avoidance of sun exposure, the use of fluocinolone-hydroquinone-tretinoin topical cream will resolve the treated melasma spots in 13—38% of patients, although few patients maintain complete clearing of melasma (1—2%).
This drug combination is not intended for long-term treatment of melasma and does not permanently cure skin melasma.
Once this treatment is discontinued, repigmentation will occur in the affected areas, although patients can continue to be managed with other treatments.
Tri Luma™ cream was granted FDA approval for the treatment of melasma in May 2002.
Indications
- melasma
For the short-term (up to 8 weeks) treatment of moderate to severe melasma of the face resulting from pregnancy, hormone replacement therapy, or the use of oral contraceptives
Side Effects
- acne vulgaris
- acneiform rash
- contact dermatitis
- corneal opacification
- Cushing’s syndrome
- dysgeusia
- edema
- erythema
- folliculitis
- glycosuria
- hyperesthesia
- hyperglycemia
- hypothalamic-pituitary-adrenal (HPA) suppression
- impaired wound healing
- infection
- miliaria
- nail discoloration
- paresthesias
- photosensitivity
- pruritus
- rash
- skin atrophy
- skin discoloration
- skin hyperpigmentation
- skin hypopigmentation
- skin irritation
- skin ulcer
- striae
- telangiectasia
- xerosis
- xerostomia
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- accidental exposure
- breast-feeding
- children
- corticosteroid hypersensitivity
- Cushing’s syndrome
- eczema
- herpes infection
- hyperglycemia
- hypothalamic-pituitary-adrenal (HPA) suppression
- infants
- infection
- measles
- occlusive dressing
- ocular exposure
- pregnancy
- skin abrasion
- sulfite hypersensitivity
- sunburn
- sunlight (UV) exposure
- varicella
Interactions
- Acetohexamide
- Adapalene; Benzoyl Peroxide
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Amiloride; Hydrochlorothiazide, HCTZ
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Atenolol; Chlorthalidone
- Azilsartan; Chlorthalidone
- Benazepril; Hydrochlorothiazide, HCTZ
- Bendroflumethiazide; Nadolol
- Benzoyl Peroxide
- Benzoyl Peroxide; Clindamycin
- Benzoyl Peroxide; Erythromycin
- Benzoyl Peroxide; Sulfur
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Candesartan; Hydrochlorothiazide, HCTZ
- Captopril; Hydrochlorothiazide, HCTZ
- Chlorothiazide
- Chlorpromazine
- Chlorpropamide
- Chlorthalidone
- Chlorthalidone; Clonidine
- Ciprofloxacin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Dextromethorphan; Promethazine
- Enalapril; Hydrochlorothiazide, HCTZ
- Eprosartan; Hydrochlorothiazide, HCTZ
- Fluphenazine
- Fosinopril; Hydrochlorothiazide, HCTZ
- Gemifloxacin
- Glimepiride
- Glimepiride; Pioglitazone
- Glimepiride; Rosiglitazone
- Glipizide
- Glipizide; Metformin
- Glyburide
- Glyburide; Metformin
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ; Irbesartan
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrochlorothiazide, HCTZ; Valsartan
- Levofloxacin
- Meperidine; Promethazine
- Mesoridazine
- Methyclothiazide
- Metolazone
- Metyrapone
- Moxifloxacin
- Norfloxacin
- Ofloxacin
- Perphenazine
- Perphenazine; Amitriptyline
- Phenothiazines
- Phenylephrine; Promethazine
- Prochlorperazine
- Promethazine
- Sulfonylureas
- Thiazide diuretics
- Thiethylperazine
- Thioridazine
- Tolazamide
- Tolbutamide
- Trifluoperazine
