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Fluocinolone Brand Names
Capex | Derma-Smoothe/FS | DermOtic Oil | Flac | Fluonid | FS Shampoo | Iluvien | Retisert | Synalar | YUTIQ
What is Fluocinolone
Fluocinolone is a synthetic fluorinated corticosteroid.
Fluocinolone is considered a medium- to high-potency topical agent; potency varies with strength applied and vehicle of topical administration. As with other topical corticosteroids, the drug is used for inflammatory corticosteroid-responsive dermatoses and psoriasis.
Fluocinolone is available in a variety of topical skin and scalp formulations used in adult and pediatric patients; the topical oil may be used in infants as young as 3 months.
An otic oil is used for the treatment of chronic eczematous external otitis.
Intravitreal implants are available for the treatment of chronic non-infectious uveitis (Retisert, Yutiq) and diabetic macular edema (Iluvien).
Fluocinolone was initially approved by the FDA in 1961.
Indications
- alopecia
- atopic dermatitis
- contact dermatitis
- dermatitis
- diabetic macular edema
- discoid lupus erythematosus
- eczema
- exfoliative dermatitis
- granuloma annulare
- lichen planus
- lichen simplex
- otitis externa
- pompholyx
- prurigo
- pruritus
- psoriasis
- Rhus dermatitis
- seborrheic dermatitis
- uveitis
- xerosis
Side Effects
- acneiform rash
- adrenocortical insufficiency
- arthralgia
- blepharedema
- blepharitis
- blurred vision
- cataracts
- conjunctival hyperemia
- conjunctivitis
- contact dermatitis
- corneal edema
- Cushing’s syndrome
- diplopia
- endophthalmitis
- erythema
- folliculitis
- foreign body sensation
- glycosuria
- growth inhibition
- headache
- hyperglycemia
- hypertension
- hypertrichosis
- hyphema
- hypothalamic-pituitary-adrenal (HPA) suppression
- hypotonia
- impaired wound healing
- increased intracranial pressure
- infection
- lacrimation
- macular edema
- maculopapular rash
- miliaria
- ocular discharge
- ocular hemorrhage
- ocular hypertension
- ocular infection
- ocular inflammation
- ocular irritation
- ocular pain
- ocular pruritus
- optic atrophy
- papilledema
- pharyngitis
- photophobia
- photopsia
- pruritus
- pseudotumor cerebri
- ptosis
- purpura
- retinal detachment
- retinal hemorrhage
- sinusitis
- skin atrophy
- skin hypopigmentation
- skin irritation
- skin ulcer
- striae
- telangiectasia
- tolerance
- visual impairment
- withdrawal
- wound dehiscence
- xerophthalmia
- xerosis
Monitoring Parameters
- intraocular pressure
- ophthalmologic exam
Contraindications
- acne rosacea
- acne vulgaris
- breast-feeding
- children
- corticosteroid hypersensitivity
- Cushing’s syndrome
- diabetes mellitus
- fungal infection
- geriatric
- glaucoma
- growth inhibition
- herpes infection
- herpes simplex keratitis (dendritic keratitis)
- hypothalamic-pituitary-adrenal (HPA) suppression
- implant insertion and removal complications
- increased intracranial pressure
- increased intraocular pressure
- infants
- infection
- measles
- neonates
- occlusive dressing
- ocular exposure
- ocular infection
- ophthalmic administration
- peanut hypersensitivity
- perioral dermatitis
- pregnancy
- skin abrasion
- skin atrophy
- varicella
- viral infection
Interactions
- Benzalkonium Chloride
- Metyrapone
Benzalkonium Chloride: (Moderate) The use of topical aluminum products (aluminum acetate, Burow’s solution or aluminum chloride) with benzalkonium chloride aqueous solutions may be incompatible.
Metyrapone: (Major) Medications which affect pituitary or adrenocortical function, including all corticosteroid therapy, should be discontinued prior to and during testing with metyrapone. Patients taking inadvertent doses of corticosteroids on the test day may exhibit abnormally high basal plasma cortisol levels and a decreased response to the test. Although systemic absorption of topical corticosteroids is minimal, temporary discontinuation of these products should be considered if possible to reduce the potential for interference with the test results.
