Flunisolide

Flunisolide Brand Names

Aerobid | Aerobid -M | Aerospan | Nasalide | Nasarel

What is Flunisolide

Flunisolide is a synthetic fluorinated corticosteroid used by respiratory or nasal inhalation. It is administered via oral inhalation for asthma or as a nasal spray for symptoms associated with seasonal or perennial allergic rhinitis.

Asthma guidelines consider orally inhaled corticosteroids (ICSs) to be the preferred pharmacologic treatment in the long-term management of persistent asthma.

The Expert Panel of the National Asthma Education and Prevention Program concluded that ICSs are the most potent and consistently effective class of medications for the long-term control of asthma in both adult and pediatric patients.

Superior efficacy of ICSs has been demonstrated over other long-term control medications including leukotriene receptor antagonists, cromolyn, and theophylline.

Flunisolide was initially approved by the FDA in 1981.

Indications

1. allergic rhinitis
2. asthma
3. bronchospasm prophylaxis
4. perennial allergies
5. seasonal allergies

For the maintenance treatment of asthma as bronchospasm prophylaxis

Monitoring Parameters

• blood glucose
• growth rate
• pulmonary function tests (PFTs)
• serum potassium
• weight

Contraindications

• acute bronchospasm
• adrenal insufficiency
• breast-feeding
• cataracts
• children
• corticosteroid hypersensitivity
• Cushing’s syndrome
• fungal infection
• geriatric
• glaucoma
• growth inhibition
• herpes infection
• hypothalamic-pituitary-adrenal (HPA) suppression
• increased intracranial pressure
• increased intraocular pressure
• infants
• infection
• neonates
• osteoporosis
• pregnancy
• status asthmaticus
• surgery
• trauma
• tuberculosis

Interactions

• Abatacept
• Acetaminophen; Aspirin, ASA; Caffeine
• Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
• Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
• Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
• Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
• Acetaminophen; Dextromethorphan; Phenylephrine
• Acetaminophen; Guaifenesin; Phenylephrine
• Acetazolamide
• Acetohexamide
• Adalimumab
• Albiglutide
• Aldesleukin, IL-2
• Alemtuzumab
• Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
• Aliskiren; Hydrochlorothiazide, HCTZ
• Alogliptin; Metformin
• Alpha-glucosidase Inhibitors
• Altretamine
• Ambenonium Chloride
• Amifampridine
• Amiloride; Hydrochlorothiazide, HCTZ
• Aminolevulinic Acid
• Aminosalicylate sodium, Aminosalicylic acid
• Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
• Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
• Amphotericin B
• Amphotericin B cholesteryl sulfate complex (ABCD)
• Amphotericin B lipid complex (ABLC)
• Amphotericin B liposomal (LAmB)
• Antithymocyte Globulin
• Antitumor antibiotics
• Argatroban
• Arsenic Trioxide
• Asparaginase Erwinia chrysanthemi
• Aspirin, ASA
• Aspirin, ASA; Butalbital; Caffeine
• Aspirin, ASA; Butalbital; Caffeine; Codeine
• Aspirin, ASA; Caffeine; Dihydrocodeine
• Aspirin, ASA; Caffeine; Orphenadrine
• Aspirin, ASA; Carisoprodol
• Aspirin, ASA; Carisoprodol; Codeine
• Aspirin, ASA; Citric Acid; Sodium Bicarbonate
• Aspirin, ASA; Dipyridamole
• Aspirin, ASA; Omeprazole
• Aspirin, ASA; Oxycodone
• Aspirin, ASA; Pravastatin
• Atenolol; Chlorthalidone
• Atracurium
• Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
• Azathioprine
• Azilsartan; Chlorthalidone
• Basiliximab
• Benazepril; Hydrochlorothiazide, HCTZ
• Bendroflumethiazide; Nadolol
• Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
• Bepridil
• Bismuth Subsalicylate
• Bismuth Subsalicylate; Metronidazole; Tetracycline
• Bisoprolol; Hydrochlorothiazide, HCTZ
• Bivalirudin
• Bortezomib
• Brompheniramine; Carbetapentane; Phenylephrine
• Brompheniramine; Dextromethorphan; Phenylephrine
• Bupropion
• Bupropion; Naltrexone
• Calcium Carbonate
• Calcium Carbonate; Magnesium Hydroxide
• Calcium Carbonate; Risedronate
• Calcium Carbonate; Simethicone
• Canagliflozin
• Canagliflozin; Metformin
• Candesartan; Hydrochlorothiazide, HCTZ
• Captopril; Hydrochlorothiazide, HCTZ
• Carbetapentane; Chlorpheniramine; Phenylephrine
• Carbetapentane; Diphenhydramine; Phenylephrine
• Carbetapentane; Guaifenesin; Phenylephrine
• Carbetapentane; Phenylephrine
• Carbetapentane; Phenylephrine; Pyrilamine
• Carbinoxamine; Hydrocodone; Phenylephrine
• Carbinoxamine; Phenylephrine
• Carmustine, BCNU
• Chlophedianol; Guaifenesin; Phenylephrine
• Chlorambucil
• Chlorothiazide
• Chlorpheniramine; Dextromethorphan; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Phenylephrine
• Chlorpheniramine; Hydrocodone; Phenylephrine
• Chlorpheniramine; Phenylephrine
• Chlorpropamide
• Chlorthalidone
• Chlorthalidone; Clonidine
• Choline Salicylate; Magnesium Salicylate
• Cimetidine
• Cisatracurium
• Citalopram
• Clindamycin
• Clofarabine
• Codeine; Phenylephrine; Promethazine
• Conivaptan
• Dapagliflozin
• Dapagliflozin; Metformin
• Dapagliflozin; Saxagliptin
• Denileukin Diftitox
• Denosumab
• Desmopressin
• Dextran
• Dextromethorphan; Diphenhydramine; Phenylephrine
• Dextromethorphan; Guaifenesin; Phenylephrine
• Digoxin
• Dipeptidyl Peptidase-4 Inhibitors
• Diphenhydramine; Hydrocodone; Phenylephrine
• Diphenhydramine; Phenylephrine
• Dofetilide
• Doxacurium
• Droperidol
• Dulaglutide
• Echinacea
• Econazole
• Efalizumab
• Empagliflozin
• Empagliflozin; Linagliptin
• Empagliflozin; Linagliptin; Metformin
• Empagliflozin; Metformin
• Enalapril; Hydrochlorothiazide, HCTZ
• Ephedrine
• Eprosartan; Hydrochlorothiazide, HCTZ
• Ertugliflozin
• Ertugliflozin; Metformin
• Ertugliflozin; Sitagliptin
• Estramustine
• Estrogens
• Exenatide
• Fluconazole
• Fluoxymesterone
• Fosinopril; Hydrochlorothiazide, HCTZ
• Gallium Ga 68 Dotatate
• Gemcitabine
• Gentamicin
• Glimepiride
• Glimepiride; Pioglitazone
• Glimepiride; Rosiglitazone
• Glipizide
• Glipizide; Metformin
• Glyburide
• Glyburide; Metformin
• Glycerol Phenylbutyrate
• Guaifenesin; Phenylephrine
• Halofantrine
• Haloperidol
• Hemin
• Heparin
• Hetastarch
• Hydralazine; Hydrochlorothiazide, HCTZ
• Hydrochlorothiazide, HCTZ
• Hydrochlorothiazide, HCTZ; Irbesartan
• Hydrochlorothiazide, HCTZ; Lisinopril
• Hydrochlorothiazide, HCTZ; Losartan
• Hydrochlorothiazide, HCTZ; Methyldopa
• Hydrochlorothiazide, HCTZ; Metoprolol
• Hydrochlorothiazide, HCTZ; Moexipril
• Hydrochlorothiazide, HCTZ; Olmesartan
• Hydrochlorothiazide, HCTZ; Propranolol
• Hydrochlorothiazide, HCTZ; Quinapril
• Hydrochlorothiazide, HCTZ; Spironolactone
• Hydrochlorothiazide, HCTZ; Telmisartan
• Hydrochlorothiazide, HCTZ; Triamterene
• Hydrochlorothiazide, HCTZ; Valsartan
• Hydrocodone; Phenylephrine
• Hydroxyurea
• Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
• Ibritumomab Tiuxetan
• Incretin Mimetics
• Indapamide
• Inebilizumab
• Insulin Degludec; Liraglutide
• Insulin Glargine; Lixisenatide
• Insulins
• Interferon Alfa-2a
• Interferon Alfa-2b
• Interferon Alfa-2b; Ribavirin
• Isoproterenol
• Isotretinoin
• L-Asparaginase Escherichia coli
• Levetiracetam
• Levomethadyl
• Linagliptin; Metformin
• Liraglutide
• Lixisenatide
• Lomustine, CCNU
• Loop diuretics
• Macimorelin
• Magnesium Salicylate
• Mannitol
• Mecasermin rinfabate
• Mecasermin, Recombinant, rh-IGF-1
• Meglitinides
• Melphalan
• Mepenzolate
• Metformin
• Metformin; Pioglitazone
• Metformin; Repaglinide
• Metformin; Rosiglitazone
• Metformin; Saxagliptin
• Metformin; Sitagliptin
• Methacholine
• Methazolamide
• Methenamine; Sodium Acid Phosphate
• Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
• Methoxsalen
• Methyclothiazide
• Metolazone
• Metyrapone
• Micafungin
• Mifepristone
• Mitoxantrone
• Mivacurium
• Moxifloxacin
• Muromonab-CD3
• Natalizumab
• Nateglinide
• Nelarabine
• Neostigmine
• Neuromuscular blockers
• Nicardipine
• Nonsteroidal antiinflammatory drugs
• Ondansetron
• Oxymetholone
• Pancuronium
• Pegaspargase
• Penicillamine
• Phenylephrine
• Phenylephrine; Promethazine
• Photosensitizing agents (topical)
• Physostigmine
• Pimozide
• Potassium
• Potassium Chloride
• Potassium Phosphate; Sodium Phosphate
• Potassium-sparing diuretics
• Pramlintide
• Prasterone, Dehydroepiandrosterone, DHEA (Dietary Supplements)
• Prasterone, Dehydroepiandrosterone, DHEA (FDA-approved)
• Propranolol
• Purine analogs
• Pyridostigmine
• Quetiapine
• Rapacuronium
• Regular Insulin
• Repaglinide
• Ritodrine
• Rituximab
• Rituximab; Hyaluronidase
• Rocuronium
• Salicylates
• Salsalate
• Sargramostim, GM-CSF
• Semaglutide
• SGLT2 Inhibitors
• Sodium Benzoate; Sodium Phenylacetate
• Sodium Chloride
• Sodium Phenylbutyrate
• Sodium Phosphate Monobasic Monohydrate; Sodium Phosphate Dibasic Anhydrous
• Somatropin, rh-GH
• Succinylcholine
• Sulfonylureas
• Telbivudine
• Testosterone
• Thiazide diuretics
• Thiazolidinediones
• Thyroid hormones
• Tobramycin
• Tolazamide
• Tolbutamide
• Tositumomab
• Tranexamic Acid
• Tretinoin, ATRA
• Tuberculin Purified Protein Derivative, PPD
• Tubocurarine
• Vancomycin
• Vecuronium
• Vigabatrin
• Vincristine Liposomal
• Vorinostat
• Warfarin
• Zafirlukast