Flibanserin

Flibanserin Brand Name– Addyi

What is Flibanserin

Flibanserin is a serotonin 5-HT1A receptor agonist and a serotonin 5-HT2A receptor antagonist.

The drug is indicated for the treatment of premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD) characterized by low sexual desire that causes marked distress or interpersonal difficulty and is NOT due to 1) a co-existing medical or psychiatric condition, 2) problems within the relationship, or 3) the effects of a medication or other substance. In clinical trials evaluating more than 5,000 women, the drug increased the number of “sexually satisfying” events per month.

Due to the risk for severe hypotension and syncope, especially when combined with alcohol, the product label carries a boxed warning requiring patients to avoid alcohol for at least 2 hours before their flibanserin dose.

Flibanserin is only available through a restricted risk evaluation and mitigation strategy (REMS) distribution program in which prescribers and dispensing pharmacies of flibanserin must be enrolled.

After many years of FDA analysis and review for efficacy and safety, flibanserin received FDA approval in 2015.

Indications

  • hypoactive sexual desire disorder

For the treatment of acquired, generalized hypoactive sexual desire disorder (HSDD) (also known as female sexual interest/arousal disorder)

Side Effects

  1. abdominal pain
  2. anxiety
  3. constipation
  4. dizziness
  5. drowsiness
  6. fatigue
  7. hypotension
  8. insomnia
  9. nausea
  10. orthostatic hypotension
  11. rash
  12. syncope
  13. vertigo
  14. xerostomia

Monitoring Parameters

  • LFTs

Contraindications

  • alcoholism
  • breast-feeding
  • cardiac disease
  • children
  • CNS depression
  • dehydration
  • driving or operating machinery
  • ethanol ingestion
  • ethanol intoxication
  • geriatric
  • hepatic disease
  • hypotension
  • hypovolemia
  • infants
  • labor
  • obstetric delivery
  • orthostatic hypotension
  • poor metabolizers
  • pregnancy
  • substance abuse
  • syncope

Interactions

  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Diphenhydramine
  • Acrivastine; Pseudoephedrine
  • Afatinib
  • Aldesleukin, IL-2
  • Amiodarone
  • Amobarbital
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Apalutamide
  • Aprepitant, Fosaprepitant
  • Armodafinil
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Omeprazole
  • Atazanavir
  • Atazanavir; Cobicistat
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Barbiturates
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Betrixaban
  • Bexarotene
  • Boceprevir
  • Bosentan
  • Brompheniramine
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Brompheniramine; Dextromethorphan; Guaifenesin
  • Brompheniramine; Dextromethorphan; Phenylephrine
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Brompheniramine; Pseudoephedrine
  • Butabarbital
  • Cannabidiol
  • Carbamazepine
  • Carbetapentane; Chlorpheniramine
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbetapentane; Pyrilamine
  • Carbinoxamine
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carbinoxamine; Phenylephrine
  • Carbinoxamine; Pseudoephedrine
  • Cenobamate
  • Ceritinib
  • Cetirizine
  • Cetirizine; Pseudoephedrine
  • Chlophedianol; Dexbrompheniramine
  • Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
  • Chloramphenicol
  • Chlorcyclizine
  • Chlorpheniramine
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dextromethorphan
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpheniramine; Pseudoephedrine
  • Cimetidine
  • Ciprofloxacin
  • Clarithromycin
  • Clemastine
  • Cobicistat
  • Cobimetinib
  • COMT inhibitors
  • Conivaptan
  • Crizotinib
  • Cyclizine
  • Cyclosporine
  • Cyproheptadine
  • Dalfopristin; Quinupristin
  • Danazol
  • Darunavir
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Delavirdine
  • Deutetrabenazine
  • Dexamethasone
  • Dexchlorpheniramine
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Digoxin
  • Diltiazem
  • Dimenhydrinate
  • Diphenhydramine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Diphenhydramine; Phenylephrine
  • Doxylamine
  • Doxylamine; Pyridoxine
  • Dronabinol
  • Dronedarone
  • Duvelisib
  • Efavirenz
  • Efavirenz; Emtricitabine; Tenofovir
  • Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
  • Elagolix
  • Elagolix; Estradiol; Norethindrone acetate
  • Elbasvir; Grazoprevir
  • Elexacaftor; tezacaftor; ivacaftor
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Enzalutamide
  • Erythromycin
  • Erythromycin; Sulfisoxazole
  • Esketamine
  • Eslicarbazepine
  • Esomeprazole
  • Esomeprazole; Naproxen
  • Ethanol
  • Ethotoin
  • Etravirine
  • Everolimus
  • Ezetimibe; Simvastatin
  • Fedratinib
  • Fenfluramine
  • Fluconazole
  • Fluoxetine
  • Fluoxetine; Olanzapine
  • Fluvoxamine
  • Fosamprenavir
  • Fosphenytoin
  • Gabapentin
  • Ginkgo, Ginkgo biloba
  • grapefruit juice
  • Hydroxyzine
  • Idelalisib
  • Imatinib
  • Indinavir
  • Irinotecan
  • Irinotecan Liposomal
  • Isavuconazonium
  • Isoniazid, INH
  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
  • Isoniazid, INH; Rifampin
  • Istradefylline
  • Itraconazole
  • Ivacaftor
  • Ketoconazole
  • Lapatinib
  • Larotrectinib
  • Lasmiditan
  • Lefamulin
  • Lemborexant
  • Letermovir
  • Levocetirizine
  • Lofexidine
  • Loperamide
  • Loperamide; Simethicone
  • Lopinavir; Ritonavir
  • Lorlatinib
  • Lumacaftor; Ivacaftor
  • Lumateperone
  • Maraviroc
  • Meclizine
  • Mephobarbital
  • Methohexital
  • Mifepristone
  • Mirtazapine
  • Mitotane
  • Modafinil
  • Nabilone
  • Nafcillin
  • Nefazodone
  • Nelfinavir
  • Netupitant, Fosnetupitant; Palonosetron
  • Nevirapine
  • Niacin; Simvastatin
  • Nicardipine
  • Nilotinib
  • Octreotide
  • Ombitasvir; Paritaprevir; Ritonavir
  • Omeprazole
  • Omeprazole; Amoxicillin; Rifabutin
  • Omeprazole; Sodium Bicarbonate
  • Opiate Agonists
  • Opiate Agonists-Antagonists
  • Oral Contraceptives
  • Osilodrostat
  • Oxcarbazepine
  • Palbociclib
  • Pazopanib
  • Pentobarbital
  • Phenobarbital
  • Phenothiazines
  • Phentermine; Topiramate
  • Phenytoin
  • Posaconazole
  • Pregabalin
  • Primidone
  • Quinine
  • Ranitidine
  • Ranolazine
  • Ribociclib
  • Ribociclib; Letrozole
  • Rifabutin
  • Rifampin
  • Rifapentine
  • Rimegepant
  • Ritonavir
  • Rucaparib
  • Saquinavir
  • Secobarbital
  • Sedating H1-blockers
  • Selpercatinib
  • Simeprevir
  • Simvastatin
  • Simvastatin; Sitagliptin
  • Sirolimus
  • Sofosbuvir; Velpatasvir
  • Sofosbuvir; Velpatasvir; Voxilaprevir
  • St. John’s Wort, Hypericum perforatum
  • Streptogramins
  • Talazoparib
  • Telaprevir
  • Telithromycin
  • Telotristat Ethyl
  • Temsirolimus
  • Tenofovir Alafenamide
  • Tezacaftor; Ivacaftor
  • Thiopental
  • Ticagrelor
  • Tipranavir
  • Topiramate
  • Topotecan
  • Trandolapril; Verapamil
  • Trazodone
  • Triprolidine
  • Tucatinib
  • Ubrogepant
  • Venetoclax
  • Verapamil
  • Voriconazole
  • Zafirlukast
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