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Fibrin Sealant Human Brand Names
ARTISS | Raplixa | TachoSil Absorbable Fibrin Sealant | TISSEEL
What is Fibrin Sealant Human
Fibrin sealant human is a human plasma-derived, fibrinogen and thrombin sealant developed to promote the adherence of autologous skin grafts to burn wounds, for hemostasis of surgical bleeding when control of bleeding by standard surgical techniques is ineffective or impractical, and for colonic anastomoses leakage prophylaxis after temporary colostomy reversal. Fibrin sealant is for topical use only.
Intravascular administration of fibrin sealant is contraindicated; life-threatening thromboembolic events may occur and the likelihood and severity of acute hypersensitivity reactions may increase in susceptible patients.
Fibrin sealant human was FDA-approved in 1998.
Indications
- anastomotic leak prophylaxis
- burns
- skin graft management
- surgical bleeding
For skin graft management by promoting adherence of autologous skin grafts to surgically prepared wound beds from burns
Side Effects
- abdominal pain
- air embolism
- anaphylactic shock
- anaphylactoid reactions
- anemia
- angioedema
- ascites
- atrial fibrillation
- bleeding
- bradycardia
- bronchospasm
- cardiac arrest
- chills
- constipation
- diarrhea
- dyspnea
- edema
- elevated hepatic enzymes
- eosinophilia
- erythema
- fever
- flushing
- GI obstruction
- headache
- hypertension
- hypophosphatemia
- hypotension
- ileus
- infection
- laryngeal edema
- lethargy
- mydriasis
- nausea
- paresthesias
- peripheral edema
- pleural effusion
- pruritus
- pulmonary embolism
- renal failure (unspecified)
- restlessness
- sinus tachycardia
- skin irritation
- thrombosis
- urticaria
- vomiting
- wheezing
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- aprotinin hypersensitivity
- bleeding
- breast-feeding
- infection
- intraarterial administration
- intravenous administration
- pregnancy
Interactions
- Povidone-Iodine
Povidone-Iodine: (Moderate) If povidone-iodine has been used to clean the wound area, thoroughly rinse and dry prior to application of fibrin sealant. The sealer protein and thrombin solutions of Artiss, TachoSil, and Tisseel can be denatured by povidone-iodine.
