Fenoldopam Brand Name– Corlopam
What is Fenoldopam
Fenoldopam is an intravenous dopamine1 agonist indicated for in-hospital, short-term (up to 48 hours) treatment of severe hypertension when rapid, but quickly reversible, emergency reduction of blood pressure is clinically indicated, including malignant hypertension with deteriorating end-organ function.
Transition to oral therapy with another agent can begin at any time after blood pressure is stable during fenoldopam infusion.
Fenoldopam is not generally considered a first-line agent for hypertensive emergencies.
It improves renal perfusion and may be beneficial in patients with impaired renal function; however, clinically significant reductions in death or renal replacement therapy (RRT) in patients at risk for acute renal failure has not been demonstrated.
Data do not consistently suggest fenoldopam reduces the incidence of acute kidney injury or prevents the need for RRT in cardiac surgery patients.
Indications
- hypertension
- hypertensive emergency
- nephrotoxicity prophylaxis
For the short-term treatment of severe hypertension (e.g., hypertensive emergency)
Side Effects
- abdominal pain
- angina
- anxiety
- chest pain (unspecified)
- dizziness
- elevated hepatic enzymes
- fever
- flushing
- headache
- heart failure
- hyperhidrosis
- hypokalemia
- hypotension
- injection site reaction
- insomnia
- muscle cramps
- myocardial infarction
- nausea
- oliguria
- palpitations
- sinus tachycardia
- ST-T wave changes
- vomiting
Monitoring Parameters
- blood pressure
- heart rate
- serum potassium
Contraindications
- asthma
- breast-feeding
- geriatric
- glaucoma
- increased intraocular pressure
- pregnancy
- sulfite hypersensitivity
Interactions
- Acebutolol
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Pseudoephedrine
- Acrivastine; Pseudoephedrine
- Aldesleukin, IL-2
- Alemtuzumab
- Aliskiren
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Aliskiren; Valsartan
- Alprostadil
- Amifostine
- Amobarbital
- Amphetamine
- Amphetamine; Dextroamphetamine
- Amyl Nitrite
- Apomorphine
- Apraclonidine
- Aripiprazole
- Articaine; Epinephrine
- Asenapine
- Atenolol
- Atenolol; Chlorthalidone
- Baclofen
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Bendroflumethiazide; Nadolol
- Benzphetamine
- Beta-blockers
- Betaxolol
- Bisoprolol
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Bortezomib
- Brimonidine; Timolol
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Dextromethorphan; Phenylephrine
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Caffeine; Ergotamine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbidopa; Levodopa
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Cariprazine
- Carteolol
- Carvedilol
- Cetirizine; Pseudoephedrine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chlophedianol; Guaifenesin; Phenylephrine
- Chloroprocaine
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- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Clozapine
- Co-Enzyme Q10, Ubiquinone
- Cocaine
- Codeine; Phenylephrine; Promethazine
- Desloratadine; Pseudoephedrine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmedetomidine
- Dexmethylphenidate
- Dextroamphetamine
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Dextromethorphan; Quinidine
- Diethylpropion
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Dihydroergotamine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Phenylephrine
- Dobutamine
- Dopamine
- Dorzolamide; Timolol
- Duloxetine
- Enflurane
- Ephedrine
- Epinephrine
- Epoprostenol
- Ergonovine
- Ergotamine
- Esmolol
- Etomidate
- Fexofenadine; Pseudoephedrine
- Fish Oil, Omega-3 Fatty Acids (Dietary Supplements)
- Fluoxetine; Olanzapine
- Fospropofol
- General anesthetics
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guaifenesin; Phenylephrine
- Guaifenesin; Pseudoephedrine
- Haloperidol
- Halothane
- Hydralazine; Isosorbide Dinitrate, ISDN
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Ibuprofen; Pseudoephedrine
- Iloperidone
- Iloprost
- Intravenous Lipid Emulsions
- Isocarboxazid
- Isoflurane
- Isoproterenol
- Isosorbide Dinitrate, ISDN
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- Ketamine
- Labetalol
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- Levodopa
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- Lofexidine
- Loratadine; Pseudoephedrine
- Lovastatin; Niacin
- Lurasidone
- Mepivacaine; Levonordefrin
- Methamphetamine
- Methohexital
- Methylphenidate
- Metoclopramide
- Metoprolol
- Midodrine
- Milrinone
- Nadolol
- Naproxen; Pseudoephedrine
- Nebivolol
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- Nesiritide, BNP
- Niacin, Niacinamide
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- Nitrates
- Nitroglycerin
- Nonsteroidal antiinflammatory drugs
- Norepinephrine
- Olanzapine
- Oxymetazoline
- Paliperidone
- Pemoline
- Penbutolol
- Pentoxifylline
- Phendimetrazine
- Phenelzine
- Phentermine
- Phentermine; Topiramate
- Phenylephrine
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