Erythromycin Sulfisoxazole

Erythromycin Sulfisoxazole Brand Names- E.S.P. | Eryzole | Pediazole

What is Erythromycin Sulfisoxazole

The combination of erythromycin ethylsuccinate and sulfisoxazole is available as a suspension for the treatment of acute otitis media caused by susceptible strains of Haemophilus influenzae.

Erythromycin sulfisoxazole may also be used to treat other infections of the upper respiratory tract due to susceptible organisms; this combination provides adequate coverage against many strains of S. pneumoniae, S. pyogenes, H. influenzae, and M. catarrhalis. Erythromycin-sulfisoxazole is especially useful in patients allergic to penicillins and cephalosporins.

Erythromycin

sulfisoxazole was granted FDA approval for the treatment of acute otitis media in November, 1979.

Indications

1. Haemophilus influenzae (beta-lactamase negative)
2. Haemophilus influenzae (beta-lactamase positive)
3. Moraxella catarrhalis
4. otitis media
5. Streptococcus pneumoniae
6. Streptococcus pyogenes (group A beta-hemolytic streptococci)
7. Streptococcus sp.

Side Effects

1. abdominal pain
2. agranulocytosis
3. anaphylactoid reactions
4. anemia
5. angioedema
6. anorexia
7. anuria
8. anxiety
9. aplastic anemia
10. ataxia
11. cough
12. crystalluria
13. depression
14. diarrhea
15. diuresis
16. dizziness
17. drowsiness
18. dyspnea
19. edema
20. elevated hepatic enzymes
21. eosinophilia
22. erythema multiforme
23. exfoliative dermatitis
24. fatigue
25. fever
26. flatulence
27. flushing
28. GI bleeding
29. glossitis
30. goiter
31. hallucinations
32. headache
33. hearing loss
34. hematuria
35. hemolytic anemia
36. hepatic necrosis
37. hepatitis
38. hypoglycemia
39. hypoprothrombinemia
40. insomnia
41. interstitial nephritis
42. jaundice
43. leukopenia
44. lupus-like symptoms
45. melena
46. methemoglobinemia
47. nausea
48. neuritis
49. oliguria
50. pallor
51. pancreatitis
52. paresthesias
53. pharyngitis
54. photosensitivity
55. pneumonitis
56. pruritus
57. pseudomembranous colitis
58. psychosis
59. purpura
60. QT prolongation
61. rash
62. seizures
63. serum sickness
64. Stevens-Johnson syndrome
65. stomatitis
66. superinfection
67. thrombocytopenia
68. tinnitus
69. torsade de pointes
70. toxic epidermal necrolysis
71. urticaria
72. vasculitis
73. ventricular tachycardia
74. vertigo
75. vomiting
76. weakness

Monitoring Parameters

• CBC
• serum creatinine/BUN
• urinalysis

Contraindications

• bone marrow suppression
• bradycardia
• breast-feeding
• colitis
• dehydration
• diarrhea
• folate deficiency megaloblastic anemia
• G6PD deficiency
• geriatric
• GI disease
• hepatic disease
• hypocalcemia
• hypokalemia
• hypomagnesemia
• infants
• inflammatory bowel disease
• long QT syndrome
• macrolide hypersensitivity
• myasthenia gravis
• neonates
• pregnancy
• pseudomembranous colitis
• QT prolongation
• renal failure
• renal impairment
• sulfonamide hypersensitivity
• sunlight (UV) exposure
• ulcerative colitis

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