Benzoyl Peroxide Erythromycin

Benzoyl Peroxide; Erythromycin Brand Names

Aktipak | Benzamycin | Benzamycin Pak

What is Benzoyl Peroxide; Erythromycin

Benzoyl peroxide erythromycin is a topical acne product. Both agents have antibacterial effects.

In addition, benzoyl peroxide has drying actions, sebostatic effects, and causes mild skin desquamation.

Benzoyl peroxide; erythromycin improves inflammatory acne lesions. Benzoyl peroxide; erythromycin is effective as monotherapy in grades II and III acne characterized by papules and pustules.

The combination of benzoyl peroxide and erythromycin is more effective than either agent alone and may decrease the development of bacterial resistance.

Benzoyl peroxide erythromycin products are not as effective in deep cystic lesions or in non-inflammatory lesions. 

Indications

  • acne vulgaris
  • Propionibacterium acnes

Side Effects

  1. blepharitis
  2. erythema
  3. ocular irritation
  4. photosensitivity
  5. pruritus
  6. skin discoloration
  7. skin irritation
  8. urticaria
  9. xerosis

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • accidental exposure
  • breast-feeding
  • diarrhea
  • eczema
  • GI disease
  • inflammatory bowel disease
  • macrolide hypersensitivity
  • myasthenia gravis
  • ocular exposure
  • pregnancy
  • pseudomembranous colitis
  • skin abrasion
  • skin disease
  • sunburn
  • sunlight (UV) exposure
  • ulcerative colitis

Interactions

  • Clindamycin; Tretinoin
  • Dapsone
  • Fluocinolone; Hydroquinone; Tretinoin
  • Halobetasol; Tazarotene
  • Hydroquinone
  • Isotretinoin
  • Mequinol; Tretinoin
  • Porfimer
  • Salicylic Acid
  • Sodium Thiosulfate; Salicylic Acid
  • Tazarotene
  • Topical Local Anesthetics
  • Tretinoin, ATRA
  • Trifarotene
  • Verteporfin