Eluxadoline Brand Name– VIBERZI
What is Eluxadoline
Eluxadoline is an oral mu and kappa opioid receptor agonist and a delta opioid receptor antagonist.
The drug is indicated for use in adults to treat irritable bowel syndrome with diarrhea (IBS-D).
FDA-approval was based on the results of two clinical studies involving a total of 2,426 adults with IBS-D. In these studies, patients were randomized to receive either eluxadoline 75 mg PO twice daily, 100 mg PO twice daily, or placebo.
At treatment week 12, the composite response rates were higher in patients receiving the 75 mg (24% and 29%) and 100 mg (25% and 30%) treatment dose vs. the placebo group.
Response to treatment was defined as a simultaneous improvement in daily worst abdominal pain score by at least 30% as compared to baseline weakly averages, and a reduction in the Bristol Stool Scale (BSS) to less than 5 on at least 50% of the days within a 12-week time interval.
Monitor recipients of eluxadoline for constipation; patients who develop severe constipation lasting more than 4 days should discontinue use of the drug.
Indications
- irritable bowel syndrome
For the treatment of irritable bowel syndrome with diarrhea (IBS-D)
Side Effects
- abdominal pain
- angioedema
- bronchospasm
- chest pain (unspecified)
- constipation
- constipation
- dizziness
- drowsiness
- dyspnea
- elevated hepatic enzymes
- euphoria
- fatigue
- flatulence
- gastroesophageal reflux
- GI perforation
- impaired cognition
- infection
- maculopapular rash
- nausea
- pancreatitis
- pharyngitis
- pruritus
- rash
- respiratory depression
- urticaria
- vomiting
- wheezing
Monitoring Parameters
- LFTs
- serum creatinine/BUN
- serum lipase
Contraindications
- abdominal pain
- alcoholism
- biliary obstruction
- breast-feeding
- cholecystectomy
- constipation
- driving or operating machinery
- ethanol ingestion
- fecal impaction
- gallbladder disease
- geriatric
- GI obstruction
- GI perforation
- hepatic disease
- pancreatitis
- pregnancy
- renal failure
- renal impairment
- serious hypersensitivity reactions or anaphylaxis
- substance abuse
Interactions
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Codeine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Propoxyphene
- Alfentanil
- Alosetron
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Anticholinergics
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Oxycodone
- Atazanavir
- Atazanavir; Cobicistat
- Atropine
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Atropine; Edrophonium
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Belladonna; Opium
- Benzhydrocodone; Acetaminophen
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Benztropine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Ceritinib
- Chlordiazepoxide; Clidinium
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Clarithromycin
- Cobicistat
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Colchicine; Probenecid
- Cyclosporine
- Daclatasvir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Dicyclomine
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Elexacaftor; tezacaftor; ivacaftor
- Eliglustat
- Eltrombopag
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Erythromycin
- Erythromycin; Sulfisoxazole
- Fentanyl
- Flavoxate
- Gemfibrozil
- Glecaprevir; Pibrentasvir
- Glycopyrrolate
- Glycopyrrolate; Formoterol
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Homatropine; Hydrocodone
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydromorphone
- Hyoscyamine
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ibuprofen; Oxycodone
- Indacaterol; Glycopyrrolate
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Leflunomide
- Lemborexant
- Letermovir
- Levorphanol
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Mepenzolate
- Meperidine
- Meperidine; Promethazine
- Methadone
- Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
- Methscopolamine
- Morphine
- Morphine; Naltrexone
- Nisoldipine
- Obeticholic Acid
- Ombitasvir; Paritaprevir; Ritonavir
- Oxybutynin
- Oxycodone
- Oxymorphone
- Ozanimod
- Pramlintide
- Probenecid
- Propantheline
- Propoxyphene
- Remifentanil
- Ribociclib
- Ribociclib; Letrozole
- Rifampin
- Ritonavir
- Rosuvastatin
- Saquinavir
- Scopolamine
- Simeprevir
- Sofosbuvir; Velpatasvir
- Sofosbuvir; Velpatasvir; Voxilaprevir
- Sufentanil
- Telithromycin
- Teriflunomide
- Tipranavir
- Tolvaptan
- Trihexyphenidyl
