Edoxaban Brand Name– Savaysa
What is Edoxaban
Edoxaban is an oral anticoagulant for reduction in the risk of stroke and systemic embolism in patients with atrial fibrillation that is unrelated to valvular heart disease and for treatment of deep venous thrombosis (DVT) and pulmonary embolism (PE) in patients initially treated with an injectable anticoagulant.
Edoxaban carries a black box warning against reduced efficacy in nonvalvular atrial fibrillation patients with CrCl greater than 95 mL/min, abrupt discontinuation, and risk of spinal/epidural hematoma in patients undergoing neuraxial anesthesia or spinal puncture.
Use in patients with prosthetic heart valves is not recommended. During clinical trials, the most common adverse events were related to bleeding.
Similar to rivaroxaban and apixaban, edoxaban has a rapid onset of effect and predictable anticoagulant effects; routine laboratory monitoring is not required.
When comparing edoxaban to warfarin, limitations of warfarin such as the unpredictable and variable effect, narrow therapeutic window requiring routine INR monitoring, and numerous food and drug interactions contributing to poor compliance are not factors associated with edoxaban therapy; however, the anticoagulant effect of edoxaban is not easily reversed.
Edoxaban was FDA-approved in January 2015.
Indications
- atrial fibrillation
- deep venous thrombosis (DVT)
- pulmonary embolism
- stroke prophylaxis
Side Effects
- abdominal pain
- anemia
- angioedema
- bleeding
- dizziness
- elevated hepatic enzymes
- epistaxis
- GI bleeding
- headache
- hematuria
- interstitial lung disease
- intracranial bleeding
- rash
- spinal hematoma
- thrombocytopenia
- urticaria
- vaginal bleeding
Monitoring Parameters
- serum creatinine
Contraindications
- abrupt discontinuation
- antiphospholipid antibody syndrome
- bleeding
- breast-feeding
- epidural anesthesia
- geriatric
- intramuscular injections
- labor
- lumbar puncture
- mechanical heart valves
- mitral stenosis
- nonvalvular atrial fibrillation in patients with a CrCl greater than 95 mL/min
- obstetric delivery
- pregnancy
- renal failure
- renal impairment
- spinal anesthesia
- surgery
Interactions
- Abciximab
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
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- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
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