Droxidopa Brand Name– NORTHERA
What is Droxidopa
Droxidopa is an oral synthetic amino acid precursor of norepinephrine.
It is used to increase blood pressure in adult patients with symptomatic neurogenic orthostatic hypotension (NOH) caused by primary autonomic failure (e.g., Parkinson’s disease, multiple system atrophy, and pure autonomic failure), dopamine beta-hydroxylase deficiency, or non-diabetic autonomic neuropathy.
Effectiveness beyond 2 weeks has not been established.
Droxidopa may cause supine hypertension and increase risk of cardiovascular events if not monitored and well-managed.
Droxidopa was FDA-approved in February 2014.
Indications
- neurogenic orthostatic hypotension
For the treatment of symptomatic neurogenic orthostatic hypotension (NOH) caused by primary autonomic failure (e.g., Parkinson’s disease, multiple system atrophy, or pure autonomic failure), dopamine beta-hydroxylase deficiency, or non-diabetic autonomic neuropathy
Adverse Reactions
- abdominal pain
- agitation
- anaphylactoid reactions
- angioedema
- arrhythmia exacerbation
- blurred vision
- bronchospasm
- chest pain (unspecified)
- delirium
- diarrhea
- dizziness
- fatigue
- hallucinations
- headache
- hypertension
- infection
- memory impairment
- nausea
- neuroleptic malignant syndrome-like symptoms
- pancreatitis
- psychosis
- rash
- stroke
- syncope
- urticaria
- vomiting
Monitoring Parameters
- blood pressure
- heart rate
Contraindications
- angina
- breast-feeding
- cardiac arrhythmias
- cardiac disease
- coronary artery disease
- heart failure
- hypertension
- hyperthermia
- mental status changes
- myocardial infarction
- pregnancy
- salicylate hypersensitivity
- tartrazine dye hypersensitivity
Interactions
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Pseudoephedrine
- Acrivastine; Pseudoephedrine
- Almotriptan
- Articaine; Epinephrine
- Atomoxetine
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Caffeine; Ergotamine
- Carbetapentane; Pseudoephedrine
- Carbidopa
- Carbidopa; Levodopa
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Pseudoephedrine
- Cetirizine; Pseudoephedrine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Pseudoephedrine
- Desloratadine; Pseudoephedrine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmethylphenidate
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Diethylpropion
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Dihydroergotamine
- Eletriptan
- Epinephrine
- Ergoloid Mesylates
- Ergonovine
- Ergot alkaloids
- Ergotamine
- Fexofenadine; Pseudoephedrine
- Frovatriptan
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guaifenesin; Pseudoephedrine
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Ibuprofen; Pseudoephedrine
- Ionic Contrast Media
- Isocarboxazid
- Linezolid
- Loratadine; Pseudoephedrine
- Methylergonovine
- Methylphenidate
- Methysergide
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Naratriptan
- Pergolide
- Phendimetrazine
- Phenelzine
- Phentermine
- Phentermine; Topiramate
- Prilocaine; Epinephrine
- Pseudoephedrine
- Racepinephrine
- Rizatriptan
- Serotonin-Receptor Agonists
- Solriamfetol
- Sumatriptan
- Tranylcypromine
- Zolmitriptan
