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Drospirenone Ethinyl Estradiol Levomefolate Brand Names
Beyaz | SAFYRAL | Tydemy
What is Drospirenone Ethinyl Estradiol Levomefolate
Drospirenone and ethinyl estradiol are used together as a combination oral contraceptive (COC).
Levomefolate calcium in the regimen provides folate supplementation. Ethinyl estradiol is a potent, synthetic estrogen.
Drospirenone is a fourth generation progestin and an analog of spironolactone with antimineralocorticoid and antiandrogenic properties. In women desiring oral contraception, this drug combination has also shown beneficial effects for other conditions.
The use of drospirenone; ethinyl estradiol improves many of the symptoms associated with premenstrual complaints, including negative mood, water retention, and increased appetite.
Drospirenone; ethinyl estradiol also improves acne in some women.
Combined hormonal contraceptives can be used in female patients from menarche to over the age of 40 years up until the time of menopause with proper selection of products.
The choice of a routine hormonal contraceptive for any given patient is based on the individual’s contraceptive needs, underlying medical conditions or risk factors for adverse effects, and individual preferences for use.
All combined oral contraceptives (COCs) have risks related to venous and arterial thromboembolism, particularly in women who smoke; all combined hormonal contraceptive labels contain a boxed warning about tobacco smoking.
The Centers for Disease Control’s U.S. Medical Eligibility Criteria describe considerations for risk vs. benefits, including medical conditions or attributes that contraindicate use; these criteria can help prescribing practitioners in product selection for individual patients.
Drospirenone may increase potassium levels in some patients; do not use drospirenone; ethinyl estradiol; levomefolate products in patients with significant risks for hyperkalemia, such as those with kidney, liver, or adrenal insufficiency.
Patients taking drugs that could increase serum potassium should consult their health care professional before taking drospirenone-containing oral contraceptive products.
Drospirenone ethinyl estradiol levomefolate contraceptive products first received FDA approval in 2010.
Indications
- acne vulgaris
- contraception
- endometriosis
- premenstrual dysphoric disorder (PMDD)
For routine contraception and to increase folate levels in women who desire to use oral contraception
Side Effects
- abdominal pain
- acne vulgaris
- alopecia
- amenorrhea
- anaphylactoid reactions
- angioedema
- anorexia
- anxiety
- appetite stimulation
- arthralgia
- asthenia
- back pain
- bowel ischemia
- breakthrough bleeding
- breast discharge
- breast enlargement
- candidiasis
- cataracts
- cervical dysplasia
- cholecystitis
- cholelithiasis
- cholestasis
- colitis
- cystitis
- depression
- diarrhea
- diplopia
- dysmenorrhea
- dyspepsia
- edema
- elevated hepatic enzymes
- emotional lability
- erythema multiforme
- erythema nodosum
- fatigue
- fluid retention
- galactorrhea
- gingivitis
- headache
- hepatitis
- hepatoma
- hirsutism
- hyperkalemia
- hyperlipidemia
- hypertension
- hypertensive crisis
- hypertriglyceridemia
- intracranial bleeding
- irritability
- jaundice
- lactation suppression
- leukorrhea
- libido decrease
- libido increase
- lupus-like symptoms
- maculopapular rash
- mastalgia
- melasma
- menorrhagia
- menstrual irregularity
- migraine
- musculoskeletal pain
- myalgia
- myocardial infarction
- nausea
- new primary malignancy
- oligomenorrhea
- optic neuritis
- pancreatitis
- papilledema
- peliosis hepatis
- pelvic pain
- photosensitivity
- porphyria
- pruritus
- pulmonary embolism
- rash
- retinal thrombosis
- rhinitis
- sinusitis
- stroke
- thromboembolism
- thrombosis
- urticaria
- vaginal discharge
- vaginal irritation
- vaginitis
- visual impairment
- vomiting
- weight gain
- weight loss
Monitoring Parameters
- pap smear
- pelvic exam
- serum creatinine
- serum potassium
Contraindications
- acquired immunodeficiency syndrome (AIDS)
- adrenal insufficiency
- angioedema
- atrial fibrillation
- breast cancer
- breast-feeding
- cerebrovascular disease
- cervical cancer
- children
- chloasma
- cholestasis
- contact lenses
- coronary artery disease
- coronary thrombosis
- depression
- diabetes mellitus
- electrolyte imbalance
- endocarditis
- endometrial cancer
- gallbladder disease
- glaucoma
- headache
- hepatic disease
- hepatitis
- hepatocellular cancer
- hereditary angioedema
- human immunodeficiency virus (HIV) infection
- hypercholesterolemia
- hyperkalemia
- hyperlipidemia
- hypertension
- hypertriglyceridemia
- hypothyroidism
- infants
- jaundice
- migraine
- myocardial infarction
- neonates
- obesity
- obstetric delivery
- ovarian cancer
- pernicious anemia
- porphyria
- pregnancy
- protein C deficiency
- protein S deficiency
- renal failure
- renal impairment
- stroke
- surgery
- systemic lupus erythematosus (SLE)
- thromboembolic disease
- thromboembolism
- thrombophlebitis
- thyroid disease
- tobacco smoking
- uterine cancer
- vaginal bleeding
- vaginal cancer
- valvular heart disease
- visual disturbance
- vitamin B12 deficiency
Interactions
- Acarbose
- Acetaminophen
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Diphenhydramine
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Pseudoephedrine
- Acetaminophen; Tramadol
- Acetohexamide
- Albiglutide
- Aliskiren
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Aliskiren; Valsartan
- Alogliptin
- Alogliptin; Metformin
- Alogliptin; Pioglitazone
- Alpha-glucosidase Inhibitors
- Alprazolam
- Amikacin
- Amiloride
- Amiloride; Hydrochlorothiazide, HCTZ
- Aminoglycosides
- Amiodarone
- Amitriptyline; Chlordiazepoxide
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amobarbital
- Amoxicillin
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amoxicillin; Clavulanic Acid
- Ampicillin
- Ampicillin; Sulbactam
- Amprenavir
- Anastrozole
- Angiotensin II receptor antagonists
- Angiotensin-converting enzyme inhibitors
- Apalutamide
- Aprepitant, Fosaprepitant
- Armodafinil
- Artemether; Lumefantrine
- Ascorbic Acid, Vitamin C
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Atazanavir
- Atazanavir; Cobicistat
- Atorvastatin
- Atorvastatin; Ezetimibe
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Azelastine; Fluticasone
- Azithromycin
- Aztreonam
- Bacitracin
- Barbiturates
- Beclomethasone
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Bendamustine
- Benzhydrocodone; Acetaminophen
- Betamethasone
- Bexarotene
- Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Blinatumomab
- Boceprevir
- Bosentan
- Brigatinib
- Bromocriptine
- Budesonide
- Budesonide; Formoterol
- Butabarbital
- Cabozantinib
- Caffeine
- Caffeine; Ergotamine
- Calaspargase pegol
- Calcium
- Calcium-channel blockers
- Canagliflozin
- Canagliflozin; Metformin
- Capecitabine
- Carbamazepine
- Carbapenems
- Carbenicillin
- Carvedilol
- Cefaclor
- Cefadroxil
- Cefazolin
- Cefdinir
- Cefditoren
- Cefepime
- Cefiderocol
- Cefixime
- Cefotaxime
- Cefotetan
- Cefoxitin
- Cefpodoxime
- Cefprozil
- Ceftaroline
- Ceftazidime
- Ceftazidime; Avibactam
- Ceftibuten
- Ceftizoxime
- Ceftolozane; Tazobactam
- Ceftriaxone
- Cefuroxime
- Cenobamate
- Cephalexin
- Ceritinib
- Charcoal
- Chenodiol
- Chloramphenicol
- Chlordiazepoxide
- Chlordiazepoxide; Clidinium
- Chlorpropamide
- Cholestyramine
- Ciclesonide
- Cimetidine
- Ciprofloxacin
- Clarithromycin
- Clevidipine
- Clindamycin
- Clobazam
- Clonazepam
- Clorazepate
- Cobicistat
- Cobimetinib
- Colchicine
- Colchicine; Probenecid
- Colesevelam
- Colestipol
- Colistimethate, Colistin, Polymyxin E
- Conivaptan
- Corticosteroids
- Cortisone
- Cosyntropin
- Cyclosporine
- Dabrafenib
- Dalbavancin
- Dantrolene
- Dapagliflozin
- Dapagliflozin; Metformin
- Dapagliflozin; Saxagliptin
- Daptomycin
- Daratumumab; Hyaluronidase
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Deferasirox
- Deflazacort
- Delafloxacin
- Delavirdine
- Demeclocycline
- Dexamethasone
- Diazepam
- Dicloxacillin
- Diltiazem
- Dipeptidyl Peptidase-4 Inhibitors
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Dirithromycin
- Doripenem
- Doxazosin
- Doxercalciferol
- Doxorubicin
- Doxycycline
- Dronabinol
- Dronedarone
- Dulaglutide
- Duloxetine
- Dutasteride; Tamsulosin
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elagolix
- Elagolix; Estradiol; Norethindrone acetate
- Elvitegravir
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Empagliflozin
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Enalapril; Felodipine
- Enasidenib
- Encorafenib
- Enzalutamide
- Eplerenone
- Eravacycline
- Ertapenem
- Ertugliflozin
- Ertugliflozin; Metformin
- Ertugliflozin; Sitagliptin
- Erythromycin
- Erythromycin; Sulfisoxazole
- Eslicarbazepine
- Esomeprazole; Naproxen
- Estazolam
- Ethanol
- Exemestane
- Exenatide
- Famotidine; Ibuprofen
- Felbamate
- Felodipine
- Fidaxomicin
- Flibanserin
- Floxuridine
- Fluconazole
- Fludrocortisone
- Flunisolide
- Fluorouracil, 5-FU
- Fluoxetine
- Fluoxetine; Olanzapine
- Flurazepam
- Fluticasone
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Fluvoxamine
- food
- Formoterol; Mometasone
- Fosamprenavir
- Fosphenytoin
- Fostemsavir
- Frovatriptan
- Gemifloxacin
- Gentamicin
- Glecaprevir; Pibrentasvir
- Glimepiride
- Glimepiride; Pioglitazone
- Glimepiride; Rosiglitazone
- Glipizide
- Glipizide; Metformin
- Glyburide
- Glyburide; Metformin
- Glycylcyclines
- grapefruit juice
- Green Tea
- Griseofulvin
- Hemin
- Heparin
- Hyaluronidase
- Hyaluronidase, Recombinant; Immune Globulin
- Hydantoins
- Hydralazine
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydralazine; Isosorbide Dinitrate, ISDN
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrocodone; Ibuprofen
- Hydrocortisone
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Icosapent ethyl
- Idelalisib
- Imipenem; Cilastatin
- Imipenem; Cilastatin; Relebactam
- Incretin Mimetics
- Indinavir
- Indomethacin
- Insulin Degludec; Liraglutide
- Insulin Glargine; Lixisenatide
- Insulins
- Isavuconazonium
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Isotretinoin
- Isradipine
- Itraconazole
- Ivosidenib
- Ixabepilone
- Kanamycin
- Ketoconazole
- Lamotrigine
- Lansoprazole; Naproxen
- Lefamulin
- Leflunomide
- Lenalidomide
- Lesinurad
- Lesinurad; Allopurinol
- Letrozole
- Levofloxacin
- Levothyroxine
- Levothyroxine; Liothyronine (Porcine)
- Levothyroxine; Liothyronine (Synthetic)
- Linagliptin
- Linagliptin; Metformin
- Lincomycin
- Lincosamides
- Linezolid
- Liothyronine
- Liraglutide
- Lixisenatide
- Lomitapide
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Lorazepam
- Lorlatinib
- Lumacaftor; Ivacaftor
- Mecamylamine
- Meglitinides
- Melatonin
- Mephobarbital
- Meropenem
- Meropenem; Vaborbactam
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Methohexital
- Methotrexate
- Methylprednisolone
- Metreleptin
- Metronidazole
- Metyrapone
- Miconazole
- Miconazole; Petrolatum; Zinc Oxide
- Midazolam
- Mifepristone
- Miglitol
- Miltefosine
- Mineral Oil
- Minocycline
- Minoxidil
- Mitotane
- Mivacurium
- Modafinil
- Mometasone
- Morphine
- Morphine; Naltrexone
- Moxifloxacin
- Mycophenolate
- Nafcillin
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Naratriptan
- Nefazodone
- Nelfinavir
- Neomycin
- Nevirapine
- Nicardipine
- Nifedipine
- Nimodipine
- Nisoldipine
- Nitrofurantoin
- Nitroprusside
- Nonsteroidal antiinflammatory drugs
- Norfloxacin
- Ofloxacin
- Omadacycline
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Amoxicillin; Rifabutin
- Oritavancin
- Ospemifene
- Oxacillin
- Oxazepam
- Oxcarbazepine
- Paromomycin
- Pazopanib
- Pegaspargase
- Penicillin G
- Penicillin G Benzathine
- Penicillin G Benzathine; Penicillin G Procaine
- Penicillin G Procaine
- Penicillin V
- Pentamidine
- Pentobarbital
- Perindopril; Amlodipine
- Pexidartinib
- Phenobarbital
- Phenothiazines
- Phenoxybenzamine
- Phentermine; Topiramate
- Phenytoin
- Piperacillin
- Piperacillin; Tazobactam
- Pitolisant
- Plazomicin
- Polymyxin B
- Polymyxins
- Posaconazole
- Potassium
- Potassium-sparing diuretics
- Pramlintide
- Prasterone, Dehydroepiandrosterone, DHEA (Dietary Supplements)
- Prasterone, Dehydroepiandrosterone, DHEA (FDA-approved)
- Prazosin
- Prednisolone
- Prednisone
- Primidone
- Propafenone
- Propoxyphene
- Pyrimethamine
- Pyrimethamine; Sulfadoxine
- Quazepam
- Raloxifene
- Ramelteon
- Ranolazine
- Rasagiline
- Reserpine
- Ribociclib
- Ribociclib; Letrozole
- Rifabutin
- Rifampin
- Rifamycins
- Rifapentine
- Riluzole
- Ritonavir
- Rituximab; Hyaluronidase
- Rivaroxaban
- Roflumilast
- Romidepsin
- Ropinirole
- Rosuvastatin
- Rufinamide
- Ruxolitinib
- Sapropterin
- Saquinavir
- Sarilumab
- Saxagliptin
- Secobarbital
- Selegiline
- Semaglutide
- SGLT2 Inhibitors
- Siltuximab
- Simvastatin; Sitagliptin
- Sincalide
- Sitagliptin
- Sofosbuvir; Velpatasvir
- Sofosbuvir; Velpatasvir; Voxilaprevir
- Somatropin, rh-GH
- Spironolactone
- St. John’s Wort, Hypericum perforatum
- Streptogramins
- Streptomycin
- Succinylcholine
- Sugammadex
- Sulfadiazine
- Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
- Sulfasalazine
- Sulfisoxazole
- Sulfonamides
- Sulfonylureas
- Sulindac
- Tacrine
- Tacrolimus
- Tamsulosin
- Tazemetostat
- Tedizolid
- Telaprevir
- Telavancin
- Telithromycin
- Telotristat Ethyl
- Temazepam
- Temsirolimus
- Terazosin
- Terbinafine
- Teriflunomide
- Testolactone
- Tetracycline
- Thalidomide
- Theophylline, Aminophylline
- Thiazolidinediones
- Thiopental
- Thyroid hormones
- Ticarcillin
- Ticarcillin; Clavulanic Acid
- Tigecycline
- Tinidazole
- Tipranavir
- Tizanidine
- tobacco
- Tobramycin
- Tocilizumab
- Tolazamide
- Tolbutamide
- Tolvaptan
- Topiramate
- Toremifene
- Trandolapril; Verapamil
- Tranexamic Acid
- Trastuzumab; Hyaluronidase
- Triamcinolone
- Triamterene
- Triazolam
- Tricyclic antidepressants
- Trimethoprim
- Tucatinib
- Ulipristal
- Ursodeoxycholic Acid, Ursodiol
- Valdecoxib
- Valproic Acid, Divalproex Sodium
- Vancomycin
- Verapamil
- Vincristine
- Vincristine Liposomal
- Vorapaxar
- Voriconazole
- Warfarin
- Zolmitriptan
- Zonisamide
