Dronabinol Brand Name– Marinol | SYNDROS
What is Dronabinol
Dronabinol is a synthetic oral preparation of delta-9-tetrahydrocannabinol (delta-9-THC), one of 66 active compounds, called cannabinoids, found in Cannabis sativa L (marijuana).
Marijuana has been used for centuries as a herbal remedy and intoxicant. Crude marijuana contains approximately 480 substances and is not approved by the US FDA for medical use.
Dronabinol provides standardized THC concentrations and does not contain the other compounds found in crude marijuana. With the discovery of an endogenous mammalian cannabinoid system and endocannabinoids (i.e., endogenous cannabinoids), there has been increased study of the cannabinoid compounds for the management of various medical conditions, including pain management, Alzheimer’s disease, and muscle spasticity/spasm associated with multiple sclerosis.
Dronabinol is FDA-approved in adults for the relief of nausea and vomiting secondary to cancer chemotherapy in patients who have failed to respond to other antiemetics; it also is approved in as an appetite stimulant in adult patients with AIDS.
Dronabinol capsules were approved by the FDA in May 1985; an oral solution was subsequently FDA approved in July 2016.
Dronabinol capsules are contraindicated in patients with a hypersensitivity to sesame seed oil; the oral solution is contraindicated in patients with hypersensitivity to alcohol, or with recent (past 14 days) use of disulfiram- or metronidazole-containing products
Indications
- anorexia
- chemotherapy-induced nausea/vomiting
- pruritus
For the treatment of chemotherapy-induced nausea/vomiting (CINV) that is refractory to conventional antiemetic agents
Side Effects
- abdominal pain
- amnesia
- anxiety
- asthenia
- ataxia
- bradycardia
- chills
- confusion
- conjunctivitis
- cough
- dehydration
- delirium
- depression
- diarrhea
- dizziness
- drowsiness
- dysphoria
- emotional lability
- euphoria
- fatigue
- hallucinations
- hyperhidrosis
- hypertension
- hypotension
- impaired cognition
- insomnia
- malaise
- myalgia
- nausea
- nightmares
- orthostatic hypotension
- palpitations
- paranoia
- peripheral vasodilation
- rash
- rhinitis
- seizures
- sinus tachycardia
- sinusitis
- syncope
- tinnitus
- tolerance
- vomiting
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- alcoholism
- angina
- bipolar disorder
- breast-feeding
- cardiac arrhythmias
- cardiac disease
- children
- CNS depression
- coronary artery disease
- dementia
- depression
- driving or operating machinery
- geriatric
- hypertension
- hypotension
- infants
- infertility
- mania
- neonates
- orthostatic hypotension
- pregnancy
- psychosis
- reproductive risk
- schizophrenia
- seizure disorder
- seizures
- sesame oil hypersensitivity
- substance abuse
- syncope
Interactions
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Pentazocine
- Acetaminophen; Pseudoephedrine
- Acetaminophen; Tramadol
- Acrivastine; Pseudoephedrine
- Aldesleukin, IL-2
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Amiodarone
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amoxapine
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amphetamine
- Amphetamine; Dextroamphetamine
- Amphotericin B
- Amphotericin B cholesteryl sulfate complex (ABCD)
- Amphotericin B lipid complex (ABLC)
- Amphotericin B liposomal (LAmB)
- Anticholinergics
- Apalutamide
- Apomorphine
- Aprepitant, Fosaprepitant
- Armodafinil
- Articaine; Epinephrine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Atazanavir
- Atazanavir; Cobicistat
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- atypical antipsychotic
- Baclofen
- Barbiturates
- Benzodiazepines
- Benzphetamine
- Bexarotene
- Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Bosentan
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Dextromethorphan; Phenylephrine
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Buprenorphine
- Buprenorphine; Naloxone
- Bupropion; Naltrexone
- Buspirone
- Butorphanol
- Cannabidiol
- Capsaicin; Metaxalone
- Carbamazepine
- Carbetapentane; Chlorpheniramine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbetapentane; Pyrilamine
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Carisoprodol
- Cenobamate
- Ceritinib
- Cetirizine
- Cetirizine; Pseudoephedrine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chlophedianol; Guaifenesin; Phenylephrine
- Chloral Hydrate
- Chloramphenicol
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Chlorzoxazone
- Cimetidine
- Ciprofloxacin
- Clarithromycin
- Clobazam
- Clomipramine
- Cobicistat
- Cocaine
- Codeine; Phenylephrine; Promethazine
- COMT inhibitors
- Conivaptan
- Crizotinib
- Cyclobenzaprine
- Cyclosporine
- Dabrafenib
- Danazol
- Dantrolene
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Deferasirox
- Delavirdine
- Desipramine
- Desloratadine; Pseudoephedrine
- Dexamethasone
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmethylphenidate
- Dextroamphetamine
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Diethylpropion
- Digoxin
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diltiazem
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Phenylephrine
- Disulfiram
- Dobutamine
- Dopamine
- Doxepin
- Dronedarone
- Droperidol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Duvelisib
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elbasvir; Grazoprevir
- Elexacaftor; tezacaftor; ivacaftor
- Elvitegravir
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Entacapone
- Enzalutamide
- Ephedrine
- Epinephrine
- Erythromycin
- Erythromycin; Sulfisoxazole
- Eslicarbazepine
- Eszopiclone
- Ethanol
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Ethosuximide
- Etravirine
- Ezogabine
- Fedratinib
- Felbamate
- Fenfluramine
- Fenofibric Acid
- Fexofenadine; Pseudoephedrine
- Flibanserin
- Fluconazole
- Fluorouracil, 5-FU
- Fluoxetine
- Fluoxetine; Olanzapine
- Flutamide
- Fluvastatin
- Fluvoxamine
- food
- Fosamprenavir
- Fosphenytoin
- Gemfibrozil
- General anesthetics
- grapefruit juice
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guaifenesin; Phenylephrine
- Guaifenesin; Pseudoephedrine
- Haloperidol
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Ibuprofen; Pseudoephedrine
- Idelalisib
- Imatinib
- Imipramine
- Indinavir
- Ipecac
- Isavuconazonium
- Isoniazid, INH
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Isoproterenol
- Itraconazole
- Ivacaftor
- Ketoconazole
- Lapatinib
- Lefamulin
- Leflunomide
- Lemborexant
- Lesinurad
- Lesinurad; Allopurinol
- Letermovir
- Levocetirizine
- Lisdexamfetamine
- Lithium
- Lopinavir; Ritonavir
- Loratadine; Pseudoephedrine
- Lorlatinib
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Maprotiline
- Mepivacaine; Levonordefrin
- Meprobamate
- Metaxalone
- Methamphetamine
- Methocarbamol
- Methylphenidate
- Metronidazole
- Metyrapone
- Midodrine
- Mifepristone
- Mirtazapine
- Mitotane
- Modafinil
- Molindone
- Monoamine oxidase inhibitors
- Nabilone
- Nafcillin
- Nalbuphine
- Naltrexone
- Naproxen; Pseudoephedrine
- Nefazodone
- Nelfinavir
- Netupitant, Fosnetupitant; Palonosetron
- Nevirapine
- Nicardipine
- Nilotinib
- Norepinephrine
- Nortriptyline
- Octreotide
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Amoxicillin; Rifabutin
- Opiate Agonists
- Oritavancin
- Orphenadrine
- Oxcarbazepine
- Palbociclib
- Pazopanib
- Pemoline
- Pentazocine
- Pentazocine; Naloxone
- Perampanel
- Perindopril; Amlodipine
- Perphenazine; Amitriptyline
- Phendimetrazine
- Phenothiazines
- Phentermine
- Phentermine; Topiramate
- Phenylephrine
- Phenylephrine; Promethazine
- Phenytoin
- Pimozide
- Pirfenidone
- Posaconazole
- Pramipexole
- Pregabalin
- Prilocaine; Epinephrine
- Procainamide
- Protriptyline
- Pseudoephedrine
- Quinine
- Racepinephrine
- Ranolazine
- Rasagiline
- Ribociclib
- Ribociclib; Letrozole
- Rifabutin
- Rifampin
- Rifapentine
- Rifaximin
- Ritodrine
- Ritonavir
- Rotigotine
- Rucaparib
- Saquinavir
- Sedating H1-blockers
- Segesterone Acetate; Ethinyl Estradiol
- Skeletal Muscle Relaxants
- Sodium Oxybate
- Solifenacin
- St. John’s Wort, Hypericum perforatum
- Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
- Sulfinpyrazone
- Suvorexant
- Sympathomimetics
- Tacrolimus
- Tapentadol
- Telithromycin
- Telotristat Ethyl
- Teniposide
- Tetrabenazine
- Tezacaftor; Ivacaftor
- Theophylline, Aminophylline
- Thiothixene
- Ticagrelor
- Tipranavir
- Tizanidine
- Tolcapone
- Topiramate
- Toremifene
- Tramadol
- Trandolapril; Verapamil
- Trazodone
- Tricyclic antidepressants
- Trimethobenzamide
- Trimipramine
- Trospium
- Tucatinib
- Valproic Acid, Divalproex Sodium
- Vemurafenib
- Verapamil
- Vigabatrin
- Vilazodone
- Voriconazole
- Warfarin
- Zafirlukast
- Zaleplon
- Zolpidem
