Doses and plasma elimination half lives of the NSAIDs

Doses and plasma elimination half lives of the NSAIDs

DrugHalf-Life (hours)Dosage
Short half-life (<6 hours)
ASA
0.253000 mg divided (max daily dose)
Diclofenac sodium (Voltaren)
Diclofenac potassium (Cataflam)
1.125–50 mg bid–tid
75 mg bid
Diclofenac solumatrix (Zorvolex)18–35 mg tid
Etodolac (Lodine)3.0/6.5 a200 mg tid–qid
400 mg tid
Fenoprofen (Nalfon)2.5200–600 mg tid–qid
Flurbiprofen (Ansaid)3.850–100 mg bid–tid
Ibuprofen (Motrin)2.1400–800 mg tid–qid
Indomethacin (Indocin)4.725 mg tid–qid
50 mg tid
75 mg SR bid
Ketoprofen (Orudis)1.850 mg qid
75 mg tid
200 mg ER qd
Tolmetin (Tolectin)1.0/6.8 a400–600 mg tid
Long half-life (>10 hours)
Diflunisal (Dolobid)
13250–500 mg bid
Nabumetone (Relafen)26500–1000 mg bid
1000–2000 mg qd
Naproxen (Naprosyn)14250–500 mg bid
Naproxen sodium (Anaprox)14275–550 mg bid
Oxaprozin (Daypro)58600–1200 mg qd
Meloxicam (Mobic)177.5–15 mg qd
Piroxicam (Feldene)5710–20 mg qd
Salicylate (Salsalate)2–15 b750–1500 mg bid
Sulindac (Clinoril)14150–200 mg bid
Celecoxib (Celebrex)11200 mg qd to100–200 mg bid

bid, Two times a day; ER, extended release; qd, each day; qid, four times a day; SR, sustained release; tid, three times a day.

a Elimination of this drug occurs in two phases, of which the first is generally more important.

b Elimination of this drug is dose-dependent.

15585

Sign up to receive the trending updates and tons of Health Tips

Join SeekhealthZ and never miss the latest health information

15856
Scroll to Top