Diphenhydramine Phenylephrine

Diphenhydramine Phenylephrine Brand Names

Alahist LQ | Aldex-CT | Benadryl Allergy Plus Congestion | Benadryl-D Allergy and Sinus | Delsym NightTime Cough & Cold Children’s | DHM/PE | Dimetapp Children’s Cold & Congestion | DiphenMax D | Diphentann D | D-Tann | Dytan-D | PediaCare Children’s Allergy and Cold | PediaCare Night Rest Cough and Cold | Pediacare Night Time Multi-Sympton | PediaTann-CT | Pediatex CT | Sudafed PE Day/Night | Sudafed PE Nighttime | Triaminic NightTime Cold & Cough | Triaminic NightTime Cold and Cough | Triaminic NightTime Cold and Cough Thin Strip | Uni-Tann D | ZoDen PD

What is Diphenhydramine Phenylephrine

Diphenhydramine and phenylephrine are used together for relief of upper respiratory symptoms such as nasal congestion, rhinorrhea, and sneezing associated with the common cold, allergic rhinitis, or other upper respiratory allergies.

Diphenhydramine is a first generation sedating antihistamine (H1-blocker) of the ethanolamine class. Ethanolamine antihistamines have significant antimuscarinic activity and produce sedation in most patients.

Phenylephrine is a sympathomimetic amine used as a decongestant to decrease nasal and sinus congestion.

Diphenhydramine phenylephrine is marketed in formulations for use in adults and children 6 years and older.

Indications

1. allergic rhinitis
2. common cold
3. nasal congestion
4. rhinorrhea
5. sneezing

For the temporary relief of symptoms such as nasal congestion, rhinorrhea, and sneezing associated with the common cold, allergic rhinitis, or other upper respiratory allergies

Monitoring Parameters

• laboratory monitoring not necessary

Contraindications

• acute myocardial infarction
• aneurysm
• angina
• anticholinergic medications
• arteriosclerosis
• asthma
• atrial fibrillation
• atrial flutter
• AV block
• bladder obstruction
• bradycardia
• breast-feeding
• bundle-branch block
• cardiac arrhythmias
• cardiac disease
• cardiomyopathy
• cerebrovascular disease
• children
• chronic obstructive pulmonary disease (COPD)
• closed-angle glaucoma
• constipation
• contact lenses
• coronary artery disease
• diabetes mellitus
• driving or operating machinery
• geriatric
• GI disease
• GI obstruction
• heart failure
• hepatic disease
• hypertension
• hyperthyroidism
• ileus
• increased intraocular pressure
• infants
• intracranial bleeding
• labor
• MAOI therapy
• myocardial infarction
• neonates
• obstetric delivery
• organic brain syndrome
• peptic ulcer disease
• peripheral vascular disease
• pregnancy
• prostatic hypertrophy
• pulmonary disease
• pyloric stenosis
• renal disease
• renal failure
• renal impairment
• status asthmaticus
• stroke
• tachycardia
• thyrotoxicosis
• ulcerative colitis
• urinary retention
• ventricular fibrillation
• ventricular tachycardia

Interactions

• Acarbose
• Acebutolol
• Acetaminophen; Aspirin, ASA; Caffeine
• Acetaminophen; Butalbital
• Acetaminophen; Butalbital; Caffeine
• Acetaminophen; Butalbital; Caffeine; Codeine
• Acetaminophen; Caffeine
• Acetaminophen; Caffeine; Dihydrocodeine
• Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
• Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Codeine
• Acetaminophen; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Dichloralphenazone; Isometheptene
• Acetaminophen; Hydrocodone
• Acetaminophen; Oxycodone
• Acetaminophen; Pentazocine
• Acetaminophen; Propoxyphene
• Acetaminophen; Pseudoephedrine
• Acetaminophen; Tramadol
• Aclidinium; Formoterol
• Acrivastine; Pseudoephedrine
• Albiglutide
• Albuterol
• Albuterol; Ipratropium
• Aldesleukin, IL-2
• Alfentanil
• Aliskiren; Amlodipine
• Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
• Aliskiren; Hydrochlorothiazide, HCTZ
• Alogliptin; Metformin
• Alogliptin; Pioglitazone
• Alosetron
• Alpha-blockers
• Alpha-glucosidase Inhibitors
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• Aminoglycosides
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• Amlodipine
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• Amlodipine; Benazepril
• Amlodipine; Celecoxib
• Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
• Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
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• Amlodipine; Valsartan
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• Aspirin, ASA; Caffeine; Orphenadrine
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• Aspirin, ASA; Oxycodone
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• Carbetapentane; Phenylephrine
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• Carbetapentane; Pyrilamine
• Carbidopa; Levodopa; Entacapone
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• Carbinoxamine; Pseudoephedrine
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• Chlorothiazide
• Chlorpheniramine; Codeine
• Chlorpheniramine; Dihydrocodeine; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
• Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Hydrocodone
• Chlorpheniramine; Hydrocodone; Phenylephrine
• Chlorpheniramine; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Pseudoephedrine
• Chlorpromazine
• Chlorthalidone
• Chlorthalidone; Clonidine
• Chlorzoxazone
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• Colchicine
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• Diethylpropion
• Digitoxin
• Digoxin
• Dihydrocodeine; Guaifenesin; Pseudoephedrine
• Dihydroergotamine
• Diltiazem
• Dipeptidyl Peptidase-4 Inhibitors
• Diphenhydramine; Hydrocodone; Phenylephrine
• Disopyramide
• Donepezil
• Donepezil; Memantine
• Dorzolamide; Timolol
• Doxazosin
• Doxercalciferol
• Doxorubicin
• Dronabinol
• Dronedarone
• Droperidol
• Dulaglutide
• Dutasteride; Tamsulosin
• Dyphylline
• Dyphylline; Guaifenesin
• Elexacaftor; tezacaftor; ivacaftor
• Eliglustat
• Elvitegravir
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
• Empagliflozin
• Empagliflozin; Linagliptin
• Empagliflozin; Linagliptin; Metformin
• Empagliflozin; Metformin
• Enalapril; Felodipine
• Enalapril; Hydrochlorothiazide, HCTZ
• Enflurane
• Entacapone
• Epinephrine
• Epoprostenol
• Eprosartan; Hydrochlorothiazide, HCTZ
• Ergoloid Mesylates
• Ergonovine
• Ergot alkaloids
• Ergotamine
• Ertugliflozin
• Ertugliflozin; Metformin
• Ertugliflozin; Sitagliptin
• Esketamine
• Esmolol
• Estazolam
• Eszopiclone
• Ethacrynic Acid
• Ethanol
• Etomidate
• Exenatide
• Ezogabine
• Felodipine
• Fenfluramine
• Fenofibric Acid
• Fentanyl
• Fexofenadine; Pseudoephedrine
• Flibanserin
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• Fluoxetine; Olanzapine
• Fluphenazine
• Flurazepam
• Fluticasone
• Fluticasone; Salmeterol
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• Formoterol
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• Fosinopril; Hydrochlorothiazide, HCTZ
• Fospropofol
• Furosemide
• Gabapentin
• Galantamine
• Gentamicin
• Ginger, Zingiber officinale
• Glimepiride; Pioglitazone
• Glimepiride; Rosiglitazone
• Glipizide; Metformin
• Glyburide; Metformin
• Glycopyrrolate; Formoterol
• Green Tea
• Guaifenesin; Hydrocodone
• Guaifenesin; Hydrocodone; Pseudoephedrine
• Guaifenesin; Pseudoephedrine
• Guanabenz
• Halogenated Anesthetics
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• Hydantoins
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• Hydrochlorothiazide, HCTZ
• Hydrochlorothiazide, HCTZ; Irbesartan
• Hydrochlorothiazide, HCTZ; Lisinopril
• Hydrochlorothiazide, HCTZ; Losartan
• Hydrochlorothiazide, HCTZ; Methyldopa
• Hydrochlorothiazide, HCTZ; Metoprolol
• Hydrochlorothiazide, HCTZ; Moexipril
• Hydrochlorothiazide, HCTZ; Olmesartan
• Hydrochlorothiazide, HCTZ; Propranolol
• Hydrochlorothiazide, HCTZ; Quinapril
• Hydrochlorothiazide, HCTZ; Spironolactone
• Hydrochlorothiazide, HCTZ; Telmisartan
• Hydrochlorothiazide, HCTZ; Triamterene
• Hydrochlorothiazide, HCTZ; Valsartan
• Hydrocodone
• Hydrocodone; Ibuprofen
• Hydrocodone; Phenylephrine
• Hydrocodone; Potassium Guaiacolsulfonate
• Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
• Hydrocodone; Pseudoephedrine
• Hydrocortisone
• Hydromorphone
• Ibuprofen; Oxycodone
• Ibuprofen; Pseudoephedrine
• Iloperidone
• Iloprost
• Incretin Mimetics
• Indacaterol
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• Indapamide
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• Levothyroxine; Liothyronine (Synthetic)
• Linagliptin; Metformin
• Linezolid
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• Lithium
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