Dicloxacillin Brand Name– Dynapen
What is Dicloxacillin
Dicloxacillin is an oral semisynthetic isoxazolyl antistaphylococcal penicillin. Like other antistaphylococcal penicillins, dicloxacillin is stable against penicillinase, is active against many of the penicillinase-producing strains of Staphylococcus aureus, and is used mainly in the treatment of infections caused by these organisms.
It is the most active of the isoxazolyl antistaphylococcal penicillins. Clinical uses of dicloxacillin include skin and soft-tissue infections, bone and joint infections, and urinary and respiratory tract infections.
Dicloxacillin was approved by the FDA in 1968.
Indications
- bacteremia
- bone and joint infections
- endocarditis
- impetigo
- infectious arthritis
- mastitis
- osteomyelitis
- pneumonia
- skin and skin structure infections
- Staphylococcus sp.
Side Effects
- abdominal pain
- agranulocytosis
- anaphylactic shock
- anaphylactoid reactions
- angioedema
- arthralgia
- bronchospasm
- diarrhea
- elevated hepatic enzymes
- eosinophilia
- exfoliative dermatitis
- fever
- hematuria
- hypotension
- interstitial nephritis
- laryngeal edema
- laryngospasm
- malaise
- myalgia
- nausea
- neutropenia
- proteinuria
- pruritus
- pseudomembranous colitis
- rash
- renal tubular necrosis
- seizures
- serum sickness
- Stevens-Johnson syndrome
- stomatitis
- superinfection
- tongue discoloration
- toxic epidermal necrolysis
- urticaria
- vomiting
Monitoring Parameters
- LFTs
- serum creatinine/BUN
Contraindications
- asthma
- breast-feeding
- carbapenem hypersensitivity
- cephalosporin hypersensitivity
- colitis
- diarrhea
- eczema
- geriatric
- GI disease
- inflammatory bowel disease
- penicillin hypersensitivity
- pregnancy
- pseudomembranous colitis
- ulcerative colitis
Interactions
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Choline Salicylate; Magnesium Salicylate
- Colchicine; Probenecid
- Dichlorphenamide
- Dienogest; Estradiol valerate
- Digoxin
- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Elagolix; Estradiol; Norethindrone acetate
- Erythromycin; Sulfisoxazole
- Estradiol; Levonorgestrel
- Estradiol; Norethindrone
- Estradiol; Norgestimate
- Ethacrynic Acid
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Furosemide
- Indomethacin
- Leuprolide; Norethindrone
- Levonorgestrel
- Magnesium Salicylate
- Mestranol; Norethindrone
- Methotrexate
- Norethindrone
- Norgestrel
- Oral Contraceptives
- Probenecid
- Pyrimethamine; Sulfadoxine
- Salsalate
- Segesterone Acetate; Ethinyl Estradiol
- Sodium Benzoate; Sodium Phenylacetate
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- Sulfadiazine
- Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
- Sulfasalazine
- Sulfisoxazole
- Sulfonamides
- Tetracyclines
- Typhoid Vaccine
- Warfarin