Dexchlorpheniramine Dextromethorphan Pseudoephedrine

Dexchlorpheniramine Dextromethorphan Pseudoephedrine Brand Names

Bromatan Plus | C-Phed DPD | DELTUSS DMX | DuraTan Forte | Dur-Tann Forte | SuTan DM | TanaCof-DM | Tanafed DMX | TanDur DM | Tri-Fed X

What is Dexchlorpheniramine Dextromethorphan Pseudoephedrine

Dexchlorpheniramine dextromethorphan pseudoephedrine combinations are used for the temporary relief of cough, itchy nose/throat, itchy, watery eyes, nasal and sinus congestion, rhinorrhea, and sneezing due to the common cold, sinusitis, and allergic rhinitis or other upper respiratory allergies.

Dexchlorpheniramine is a first-generation sedating antihistamine (H1-blocker) of the alkylamine class that is commonly used for treating symptoms related to histamine release such as rhinorrhea and sneezing.

Dextromethorphan is a non-opioid cough suppressant used for its antitussive property. Pseudoephedrine is a sympathomimetic amine used as a decongestant to decrease nasal and sinus congestion.

Dexchlorpheniramine; dextromethorphan; pseudoephedrine combinations have mostly been removed from marketing in the U.S.; only a few oral solutions remain available for non-prescription use in adults and children 6 years and older

Indications

1. allergic rhinitis
2. common cold
3. cough
4. nasal congestion
5. rhinorrhea
6. sneezing

For the relief of symptoms due to the common cold or allergic rhinitis or other upper respiratory allergies, including cough, itchy nose/throat, itchy, watery eyes, rhinorrhea, sinus and nasal congestion, and sneezing

Side Effects

1. abdominal pain
2. acute generalized exanthematous pustulosis (AGEP)
3. agranulocytosis
4. anaphylactic shock
5. anaphylactoid reactions
6. angina
7. anorexia
8. anxiety
9. arrhythmia exacerbation
10. ataxia
11. AV block
12. blurred vision
13. bradycardia
14. bronchial secretions
15. colitis
16. confusion
17. constipation
18. contact dermatitis
19. diarrhea
20. diplopia
21. dizziness
22. drowsiness
23. dysuria
24. erythema
25. euphoria
26. excitability
27. fatigue
28. hallucinations
29. headache
30. hemolytic anemia
31. hypertension
32. hypotension
33. insomnia
34. irritability
35. lethargy
36. mydriasis
37. myocardial infarction
38. nasal congestion
39. nasal dryness
40. nausea
41. neuritis
42. ocular hypertension
43. palpitations
44. paresthesias
45. photophobia
46. photosensitivity
47. polyuria
48. premature ventricular contractions (PVCs)
49. psychosis
50. rash
51. restlessness
52. seizures
53. serotonin syndrome
54. sinus tachycardia
55. stroke
56. supraventricular tachycardia (SVT)
57. thrombocytopenia
58. tinnitus
59. tremor
60. urinary retention
61. urticaria
62. vertigo
63. vomiting
64. weakness
65. wheezing
66. xerophthalmia
67. xerostomia

Monitoring Parameters

• laboratory monitoring not necessary

Contraindications

• acute myocardial infarction
• aneurysm
• angina
• anticholinergic medications
• arteriosclerosis
• asthma
• AV block
• bladder obstruction
• bradycardia
• breast-feeding
• bronchitis
• bundle-branch block
• cardiac arrhythmias
• cardiac disease
• cardiomyopathy
• cerebrovascular disease
• children
• chronic obstructive pulmonary disease (COPD)
• closed-angle glaucoma
• constipation
• contact lenses
• coronary artery disease
• diabetes mellitus
• driving or operating machinery
• emphysema
• geriatric
• GI obstruction
• head trauma
• heart failure
• hepatic disease
• hypertension
• hyperthyroidism
• ileus
• increased intracranial pressure
• increased intraocular pressure
• infants
• intracranial bleeding
• labor
• MAOI therapy
• neonates
• obstetric delivery
• organic brain syndrome
• peptic ulcer disease
• peripheral vascular disease
• pregnancy
• prostatic hypertrophy
• pyloric stenosis
• renal disease
• renal failure
• renal impairment
• status asthmaticus
• stroke
• tachycardia
• thyrotoxicosis
• tobacco smoking
• ulcerative colitis
• urinary retention
• ventricular tachycardia

Interactions

• Abiraterone
• Acarbose
• Acebutolol
• Acetaminophen; Aspirin, ASA; Caffeine
• Acetaminophen; Butalbital
• Acetaminophen; Butalbital; Caffeine
• Acetaminophen; Butalbital; Caffeine; Codeine
• Acetaminophen; Caffeine
• Acetaminophen; Caffeine; Dihydrocodeine
• Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
• Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
• Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
• Acetaminophen; Codeine
• Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
• Acetaminophen; Dextromethorphan; Phenylephrine
• Acetaminophen; Dichloralphenazone; Isometheptene
• Acetaminophen; Guaifenesin; Phenylephrine
• Acetaminophen; Hydrocodone
• Acetaminophen; Oxycodone
• Acetaminophen; Pentazocine
• Acetaminophen; Propoxyphene
• Acetazolamide
• Aclidinium; Formoterol
• Albiglutide
• Albuterol
• Albuterol; Ipratropium
• Alfentanil
• Aliskiren; Amlodipine
• Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
• Aliskiren; Hydrochlorothiazide, HCTZ
• Alkalinizing Agents
• Alogliptin; Metformin
• Alogliptin; Pioglitazone
• Alosetron
• Alpha-blockers
• Alpha-glucosidase Inhibitors
• Aluminum Hydroxide
• Aluminum Hydroxide; Magnesium Carbonate
• Aluminum Hydroxide; Magnesium Hydroxide
• Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
• Aluminum Hydroxide; Magnesium Trisilicate
• Amantadine
• Ambenonium Chloride
• Amiloride; Hydrochlorothiazide, HCTZ
• Amiodarone
• Amlodipine
• Amlodipine; Atorvastatin
• Amlodipine; Benazepril
• Amlodipine; Celecoxib
• Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
• Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
• Amlodipine; Olmesartan
• Amlodipine; Telmisartan
• Amlodipine; Valsartan
• Ammonium Chloride
• Amobarbital
• Amoxapine
• Amphetamine
• Amphetamine; Dextroamphetamine
• Amphetamine; Dextroamphetamine Salts
• Angiotensin II receptor antagonists
• Angiotensin-converting enzyme inhibitors
• Anticholinergics
• Apomorphine
• Arformoterol
• Aripiprazole
• Artemether; Lumefantrine
• Asenapine
• Aspirin, ASA; Butalbital; Caffeine
• Aspirin, ASA; Butalbital; Caffeine; Codeine
• Aspirin, ASA; Caffeine; Dihydrocodeine
• Aspirin, ASA; Caffeine; Orphenadrine
• Aspirin, ASA; Carisoprodol
• Aspirin, ASA; Carisoprodol; Codeine
• Aspirin, ASA; Oxycodone
• Atazanavir; Cobicistat
• Atenolol
• Atenolol; Chlorthalidone
• Atomoxetine
• Atropine
• Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
• Atropine; Difenoxin
• Atropine; Diphenoxylate
• Atropine; Edrophonium
• Atropine; Hyoscyamine; Phenobarbital; Scopolamine
• Azelastine
• Azelastine; Fluticasone
• Azilsartan; Chlorthalidone
• Baclofen
• Barbiturates
• Belladonna Alkaloids; Ergotamine; Phenobarbital
• Belladonna; Opium
• Benazepril
• Benazepril; Hydrochlorothiazide, HCTZ
• Bendroflumethiazide; Nadolol
• Benzodiazepines
• Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
• Benzphetamine
• Beta-blockers
• Betaxolol
• Bethanechol
• Bisoprolol
• Bisoprolol; Hydrochlorothiazide, HCTZ
• Bosentan
• Bretylium
• Brimonidine; Timolol
• Bromocriptine
• Brompheniramine; Carbetapentane; Phenylephrine
• Brompheniramine; Dextromethorphan; Phenylephrine
• Brompheniramine; Guaifenesin; Hydrocodone
• Brompheniramine; Hydrocodone; Pseudoephedrine
• Budesonide; Formoterol
• Bumetanide
• Buprenorphine
• Buprenorphine; Naloxone
• Bupropion
• Bupropion; Naltrexone
• Buspirone
• Butabarbital
• Butorphanol
• Caffeine
• Caffeine; Ergotamine
• Calcium Carbonate
• Calcium Carbonate; Magnesium Hydroxide
• Calcium Carbonate; Risedronate
• Calcium Carbonate; Simethicone
• Calcium-channel blockers
• Canagliflozin
• Canagliflozin; Metformin
• Candesartan; Hydrochlorothiazide, HCTZ
• Cannabidiol
• Capsaicin; Metaxalone
• Captopril
• Captopril; Hydrochlorothiazide, HCTZ
• Carbetapentane; Chlorpheniramine
• Carbetapentane; Chlorpheniramine; Phenylephrine
• Carbetapentane; Diphenhydramine; Phenylephrine
• Carbetapentane; Guaifenesin
• Carbetapentane; Guaifenesin; Phenylephrine
• Carbetapentane; Phenylephrine
• Carbetapentane; Phenylephrine; Pyrilamine
• Carbetapentane; Pseudoephedrine
• Carbetapentane; Pyrilamine
• Carbidopa; Levodopa; Entacapone
• Carbinoxamine; Hydrocodone; Phenylephrine
• Carbinoxamine; Hydrocodone; Pseudoephedrine
• Carbinoxamine; Phenylephrine
• Cardiac glycosides
• Carisoprodol
• Carteolol
• Carvedilol
• Celecoxib
• Cenobamate
• Cetirizine
• Cetirizine; Pseudoephedrine
• Chlophedianol; Guaifenesin; Phenylephrine
• Chlorothiazide
• Chlorpheniramine; Codeine
• Chlorpheniramine; Dextromethorphan; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
• Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Hydrocodone
• Chlorpheniramine; Hydrocodone; Phenylephrine
• Chlorpheniramine; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Phenylephrine
• Chlorpromazine
• Chlorthalidone
• Chlorthalidone; Clonidine
• Chlorzoxazone
• Cinacalcet
• Citalopram
• Clevidipine
• Clobazam
• Clonidine
• Clozapine
• Cobicistat
• Cocaine
• Codeine
• Codeine; Guaifenesin
• Codeine; Phenylephrine; Promethazine
• Codeine; Promethazine
• Colchicine
• Colchicine; Probenecid
• COMT inhibitors
• Cyclobenzaprine
• Dacomitinib
• Dantrolene
• Dapagliflozin
• Dapagliflozin; Metformin
• Dapagliflozin; Saxagliptin
• Daratumumab; Hyaluronidase
• Darifenacin
• Darunavir; Cobicistat
• Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
• Delavirdine
• Desloratadine
• Desloratadine; Pseudoephedrine
• Desvenlafaxine
• Dexmedetomidine
• Dextroamphetamine
• Dextromethorphan; Diphenhydramine; Phenylephrine
• Dextromethorphan; Guaifenesin; Phenylephrine
• Dextromethorphan; Promethazine
• Digitoxin
• Digoxin
• Dihydrocodeine; Guaifenesin; Pseudoephedrine
• Dihydroergotamine
• Diltiazem
• Dipeptidyl Peptidase-4 Inhibitors
• Diphenhydramine; Hydrocodone; Phenylephrine
• Diphenhydramine; Phenylephrine
• Disopyramide
• Donepezil
• Donepezil; Memantine
• Dopamine
• Dorzolamide; Timolol
• Dronabinol
• Dronedarone
• Droperidol
• Droxidopa
• Dulaglutide
• Duloxetine
• Dyphylline
• Dyphylline; Guaifenesin
• Eliglustat
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
• Empagliflozin
• Empagliflozin; Linagliptin
• Empagliflozin; Linagliptin; Metformin
• Empagliflozin; Metformin
• Enalapril, Enalaprilat
• Enalapril; Felodipine
• Enalapril; Hydrochlorothiazide, HCTZ
• Entacapone
• Ephedrine
• Epoprostenol
• Eprosartan; Hydrochlorothiazide, HCTZ
• Ergoloid Mesylates
• Ergonovine
• Ergot alkaloids
• Ergotamine
• Ertugliflozin
• Ertugliflozin; Metformin
• Ertugliflozin; Sitagliptin
• Escitalopram
• Esmolol
• Eszopiclone
• Ethacrynic Acid
• Ethanol
• Etomidate
• Exenatide
• Ezogabine
• Fedratinib
• Felodipine
• Fentanyl
• Flibanserin
• Fluoxetine
• Fluoxetine; Olanzapine
• Fluphenazine
• Fluticasone; Salmeterol
• Fluticasone; Umeclidinium; Vilanterol
• Fluticasone; Vilanterol
• Fluvoxamine
• Formoterol
• Formoterol; Mometasone
• Fosinopril
• Fosinopril; Hydrochlorothiazide, HCTZ
• Fospropofol
• Furosemide
• Gabapentin
• Galantamine
• Ginger, Zingiber officinale
• Givosiran
• Glimepiride; Pioglitazone
• Glimepiride; Rosiglitazone
• Glipizide; Metformin
• Glyburide; Metformin
• Glycopyrrolate; Formoterol
• grapefruit juice
• Green Tea
• Guaifenesin; Hydrocodone
• Guaifenesin; Hydrocodone; Pseudoephedrine
• Guaifenesin; Phenylephrine
• Guanabenz
• Halogenated Anesthetics
• Haloperidol
• Heparin
• Homatropine; Hydrocodone
• Hyaluronidase
• Hyaluronidase, Recombinant; Immune Globulin
• Hydantoins
• Hydralazine; Hydrochlorothiazide, HCTZ
• Hydrochlorothiazide, HCTZ
• Hydrochlorothiazide, HCTZ; Irbesartan
• Hydrochlorothiazide, HCTZ; Lisinopril
• Hydrochlorothiazide, HCTZ; Losartan
• Hydrochlorothiazide, HCTZ; Methyldopa
• Hydrochlorothiazide, HCTZ; Metoprolol
• Hydrochlorothiazide, HCTZ; Moexipril
• Hydrochlorothiazide, HCTZ; Olmesartan
• Hydrochlorothiazide, HCTZ; Propranolol
• Hydrochlorothiazide, HCTZ; Quinapril
• Hydrochlorothiazide, HCTZ; Spironolactone
• Hydrochlorothiazide, HCTZ; Telmisartan
• Hydrochlorothiazide, HCTZ; Triamterene
• Hydrochlorothiazide, HCTZ; Valsartan
• Hydrocodone
• Hydrocodone; Ibuprofen
• Hydrocodone; Phenylephrine
• Hydrocodone; Potassium Guaiacolsulfonate
• Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
• Hydrocodone; Pseudoephedrine
• Hydromorphone
• Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
• Ibuprofen; Oxycodone
• Iloperidone
• Iloprost
• Imatinib
• Incretin Mimetics
• Indacaterol
• Indacaterol; Glycopyrrolate
• Indapamide
• Insulin Degludec; Liraglutide
• Insulin Glargine; Lixisenatide
• Insulins
• Iobenguane I 131
• Isocarboxazid
• Isradipine
• Ketamine
• Labetalol
• Lasmiditan
• Lemborexant
• Levalbuterol
• Levobetaxolol
• Levobunolol
• Levocetirizine
• Levomethadyl
• Levomilnacipran
• Levorphanol
• Levothyroxine
• Levothyroxine; Liothyronine (Porcine)
• Levothyroxine; Liothyronine (Synthetic)
• Linagliptin; Metformin
• Linezolid
• Liothyronine
• Liraglutide
• Lisinopril
• Lithium
• Lixisenatide
• Loop diuretics
• Loratadine
• Loratadine; Pseudoephedrine
• Lorcaserin
• Loxapine
• Lumateperone
• Lurasidone
• Macitentan
• Magnesium Salts
• Maprotiline
• Mecamylamine
• Meclizine
• Meglitinides
• Melatonin
• Memantine
• Meperidine
• Meperidine; Promethazine
• Mephobarbital
• Meprobamate
• Metaproterenol
• Metaxalone
• Metformin
• Metformin; Pioglitazone
• Metformin; Repaglinide
• Metformin; Rosiglitazone
• Metformin; Saxagliptin
• Metformin; Sitagliptin
• Methadone
• Methamphetamine
• Methazolamide
• Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
• Methocarbamol
• Methohexital
• Methyclothiazide
• Methyldopa
• Methylene Blue
• Methylergonovine
• Methysergide
• Metoclopramide
• Metolazone
• Metoprolol
• Metyrapone
• Metyrosine
• Midodrine
• Miglitol
• Milnacipran
• Minocycline
• Mirabegron
• Mirtazapine
• Mitotane
• Moexipril
• Molindone
• Monoamine oxidase inhibitors
• Morphine
• Morphine; Naltrexone
• Nabilone
• Nadolol
• Nalbuphine
• Nebivolol
• Nebivolol; Valsartan
• Nefazodone
• Nicardipine
• Nicotine
• Nifedipine
• Nimodipine
• Nisoldipine
• Nitrates
• Norepinephrine
• Olanzapine
• Opiate Agonists
• Oritavancin
• Orphenadrine
• Oxycodone
• Oxymorphone
• Ozanimod
• Paliperidone
• Panobinostat
• Paroxetine
• Pazopanib
• Peginterferon Alfa-2b
• Penbutolol
• Pentazocine
• Pentazocine; Naloxone
• Pentobarbital
• Perampanel
• Pergolide
• Perindopril
• Perindopril; Amlodipine
• Perphenazine
• Perphenazine; Amitriptyline
• Phenelzine
• Phenobarbital
• Phenylephrine
• Phenylephrine; Promethazine
• Pimozide
• Pindolol
• Pioglitazone
• Pirbuterol
• Pitolisant
• Potassium-sparing diuretics
• Pramipexole
• Pramlintide
• Pregabalin
• Primidone
• Procarbazine
• Prochlorperazine
• Promethazine
• Propafenone
• Propofol
• Propoxyphene
• Propranolol
• Quetiapine
• Quinapril
• Quinine
• Racepinephrine
• Ramelteon
• Ramipril
• Rasagiline
• Remifentanil
• Reserpine
• Riociguat
• Risperidone
• Rituximab; Hyaluronidase
• Rivastigmine
• Rolapitant
• Ropinirole
• Rosiglitazone
• Safinamide
• Salmeterol
• Secobarbital
• Selegiline
• Selexipag
• Semaglutide
• Serotonin-Receptor Agonists
• Sertraline
• SGLT2 Inhibitors
• Sibutramine
• Sincalide
• Sodium Iodide
• Solifenacin
• Solriamfetol
• Sotalol
• St. John’s Wort, Hypericum perforatum
• Sufentanil
• Sulfonylureas
• Suvorexant
• Tacrine
• Tasimelteon
• Tedizolid
• Terbinafine
• Terbutaline
• Thalidomide
• Theophylline, Aminophylline
• Thiazide diuretics
• Thiazolidinediones
• Thiopental
• Thioridazine
• Thiothixene
• Thyroid hormones
• Timolol
• Tizanidine
• Tocilizumab
• Tolcapone
• Torsemide
• Trandolapril
• Trandolapril; Verapamil
• Tranylcypromine
• Trastuzumab; Hyaluronidase
• Trazodone
• Treprostinil
• Tricyclic antidepressants
• Trifluoperazine
• Trimethobenzamide
• Trospium
• Umeclidinium; Vilanterol
• Vasodilators
• Vasopressors
• Vemurafenib
• Venlafaxine
• Verapamil
• Vigabatrin
• Vilazodone
• Vortioxetine
• Yohimbine
• Zaleplon
• Ziconotide
• Ziprasidone
• Zolpidem