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Desvenlafaxine Brand Names- Khedezla | Pristiq
What is Desvenlafaxine
Desvenlafaxine the major active metabolite of venlafaxine, is an oral serotonin norepinephrine reuptake inhibitor (SNRI) used for the treatment of major depressive disorder in adults.
SNRIs are not approved in pediatric patients with depression; however, the American Academy of Child and Adolescent Psychiatry (AACAP) guidelines recommend antidepressants when nonpharmacologic treatment is insufficient or illness severity is high.
Due to limited data in treating pediatric depression, SNRIs are generally reserved for pediatric patients with documented antidepressant treatment failure or intolerability to a selective serotonin reuptake inhibitor (SSRI).
Desvenlafaxine is approved in some countries outside of the U.S. for treating vasomotor symptoms (e.g., hot flashes) associated with menopause.
Although hormonal therapy is the most effective treatment for menopause-related vasomotor symptoms, the American College of Obstetricians and Gynecologists (ACOG) and the North American Menopause Society (NAMS) guidelines for non-hormonal therapy consider desvenlafaxine an effective alternative for women who cannot or do not wish to use hormonal therapy.
Unlike some other SNRIs, desvenlafaxine does not appear to be effective in treating the symptoms of fibromyalgia.
Similar to other SNRIs, desvenlafaxine may increase blood pressure and heart rate and caution is recommended when conditions are present that may be adversely affected by increased blood pressure or heart rate.
Product labels for all antidepressants contain a boxed warning related to an increased risk of suicidality in children, adolescents, and young adults during the initial stages of therapy or during dose changes when treating depression or other conditions; therefore, the necessity of pharmacologic therapy versus the potential risks should be carefully considered in these populations.
Indications
- depression
- hot flashes
- menopause
For the treatment of major depression
Side Effects
- abnormal dreams
- agitation
- akathisia
- alopecia
- angioedema
- anorexia
- anxiety
- asthenia
- bleeding
- blurred vision
- cardiomyopathy
- chills
- constipation
- cough
- depression
- dizziness
- drowsiness
- dysgeusia
- dyspnea
- dystonic reaction
- ecchymosis
- ejaculation dysfunction
- elevated hepatic enzymes
- eosinophilic pneumonia
- epistaxis
- erythema multiforme
- fatigue
- flushing
- GI bleeding
- hallucinations
- hematoma
- hostility
- hypercholesterolemia
- hyperhidrosis
- hyperprolactinemia
- hypertension
- hypertriglyceridemia
- hyponatremia
- impotence (erectile dysfunction)
- insomnia
- irritability
- libido decrease
- mania
- musculoskeletal pain
- mydriasis
- myocardial infarction
- nausea
- neonatal abstinence syndrome
- orgasm dysfunction
- orthostatic hypotension
- pancreatitis
- peripheral vasodilation
- petechiae
- photosensitivity
- platelet dysfunction
- proteinuria
- rash
- restlessness
- seizures
- serotonin syndrome
- SIADH
- sinus tachycardia
- Stevens-Johnson syndrome
- suicidal ideation
- syncope
- teeth grinding (bruxism)
- tinnitus
- toxic epidermal necrolysis
- tremor
- urinary retention
- vertigo
- vomiting
- weight gain
- weight loss
- withdrawal
- xerostomia
- yawning
Monitoring Parameters
- blood pressure
- serum creatinine
Contraindications
- abrupt discontinuation
- anticoagulant therapy
- bipolar disorder
- bleeding
- breast-feeding
- cardiac disease
- cerebrovascular disease
- children
- closed-angle glaucoma
- dehydration
- desvenlafaxine hypersensitivity
- driving or operating machinery
- eclampsia
- electroconvulsive therapy (ECT)
- eosinophilic pneumonia
- ethanol ingestion
- geriatric
- GI bleeding
- hepatic disease
- hypertension
- hyponatremia
- hypovolemia
- increased intraocular pressure
- mania
- MAOI therapy
- neonates
- obstetric delivery
- pregnancy
- renal failure
- renal impairment
- seizure disorder
- suicidal ideation
- thrombolytic therapy
- venlafaxine hypersensitivity
Interactions
- Abciximab
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Pentazocine
- Acetaminophen; Tramadol
- Almotriptan
- Alteplase
- Aminosalicylate sodium, Aminosalicylic acid
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amlodipine; Celecoxib
- Amphetamine; Dextroamphetamine Salts
- Anagrelide
- Antithrombin III
- Apixaban
- Argatroban
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Atazanavir; Cobicistat
- Atomoxetine
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Benzhydrocodone; Acetaminophen
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Benzphetamine
- Betrixaban
- Bismuth Subsalicylate
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Bivalirudin
- Brompheniramine; Dextromethorphan; Guaifenesin
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Buprenorphine
- Buprenorphine; Naloxone
- Buspirone
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Celecoxib
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dextromethorphan
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpromazine
- Choline Salicylate; Magnesium Salicylate
- Cilostazol
- Citalopram
- Clomipramine
- Clopidogrel
- Cobicistat
- Cocaine
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Cyclobenzaprine
- Dabigatran
- Dalteparin
- Danaparoid
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Desipramine
- Desirudin
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmethylphenidate
- Dextromethorphan
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Guaifenesin; Potassium Guaiacolsulfonate
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Dextromethorphan; Promethazine
- Dextromethorphan; Quinidine
- Diclofenac
- Diclofenac; Misoprostol
- Diflunisal
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Dipyridamole
- Diuretics
- Dolasetron
- Doxepin
- Duloxetine
- Edoxaban
- Eletriptan
- Eliglustat
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Enoxaparin
- Eptifibatide
- Ergot alkaloids
- Escitalopram
- Esomeprazole; Naproxen
- Etodolac
- Famotidine; Ibuprofen
- Fenoprofen
- Fentanyl
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluphenazine
- Flurbiprofen
- Fluvoxamine
- Fondaparinux
- Frovatriptan
- Granisetron
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Haloperidol
- Heparin
- Homatropine; Hydrocodone
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Imipramine
- Indomethacin
- Iobenguane I 131
- Isoniazid, INH
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Ketoprofen
- Ketorolac
- Lansoprazole; Naproxen
- Lasmiditan
- Lepirudin
- Levomilnacipran
- Linezolid
- Lisdexamfetamine
- Lithium
- Loperamide
- Loperamide; Simethicone
- Lorcaserin
- Magnesium Salicylate
- Meclofenamate Sodium
- Mefenamic Acid
- Meloxicam
- Meperidine
- Meperidine; Promethazine
- Methamphetamine
- Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
- Methylene Blue
- Methylphenidate
- Metoprolol
- Mexiletine
- Milnacipran
- Mirtazapine
- Monoamine oxidase inhibitors
- Morphine
- Morphine; Naltrexone
- Nabumetone
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Naratriptan
- Nebivolol
- Nebivolol; Valsartan
- Nefazodone
- Netupitant, Fosnetupitant; Palonosetron
- Nonsteroidal antiinflammatory drugs
- Nortriptyline
- Ondansetron
- Oxaprozin
- Palonosetron
- Paroxetine
- Pentazocine
- Pentazocine; Naloxone
- Pentosan
- Perphenazine
- Perphenazine; Amitriptyline
- Phentermine
- Phentermine; Topiramate
- Piroxicam
- Prasugrel
- Procarbazine
- Prochlorperazine
- Propranolol
- Protriptyline
- Rasagiline
- Remifentanil
- Reteplase, r-PA
- Risperidone
- Rivaroxaban
- Rizatriptan
- Rofecoxib
- Safinamide
- Salicylates
- Salsalate
- Serotonin-Receptor Agonists
- Sertraline
- Sibutramine
- Solriamfetol
- St. John’s Wort, Hypericum perforatum
- Streptokinase
- Sulindac
- Sumatriptan
- Tapentadol
- Tedizolid
- Tenecteplase
- Tetrabenazine
- Thiethylperazine
- Thioridazine
- Thrombolytic Agents
- Ticagrelor
- Ticlopidine
- Tinzaparin
- Tirofiban
- Tolmetin
- Tolterodine
- Tramadol
- Trazodone
- Trifluoperazine
- Trimipramine
- Urokinase
- Valdecoxib
- Valerian, Valeriana officinalis
- Venlafaxine
- Vilazodone
- Vorapaxar
- Vortioxetine
- Warfarin
- Zolmitriptan
- Zolpidem
